Immunoglobulin-Gene Rearrangement in Benign Lymphoepithelial Lesions

Thomas V. Colby, P. G. Isaacson, Elisabet Hyjek, G. S. Panayi, Bruce Freimark, Robert I. Fox, Andrew Fishleder, Raymond Tubbs, Howard Levine, Bonnie Hesse

Research output: Contribution to journalLetter

6 Scopus citations

Abstract

To the Editor: The presence of immunoglobulin-gene rearrangements in benign lymphoepithelial lesions of salivary glands, described by Fishleder et al. (April 30 issue),1 is not entirely surprising. For a number of years, I have considered such lesions markers of abnormal lymphoid proliferation, on the basis of my own experience as well as a number of reports in the literature.2 One series conspicuously lacking from the discussion of Fishleder et al. is that of Schmid et al., which describes 45 cases involving immunologic-marker studies.3 It was shown that monoclonal foci of varying size were present in nearly all 45 cases, and…

Original languageEnglish (US)
Pages (from-to)1157-1159
Number of pages3
JournalNew England Journal of Medicine
Volume317
Issue number18
DOIs
StatePublished - Oct 29 1987

ASJC Scopus subject areas

  • Medicine(all)

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    Colby, T. V., Isaacson, P. G., Hyjek, E., Panayi, G. S., Freimark, B., Fox, R. I., Fishleder, A., Tubbs, R., Levine, H., & Hesse, B. (1987). Immunoglobulin-Gene Rearrangement in Benign Lymphoepithelial Lesions. New England Journal of Medicine, 317(18), 1157-1159. https://doi.org/10.1056/NEJM198710293171815