Immunoglobulin G4-Related Disease and the Lung

Jay H. Ryu, Eunhee S. Yi

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

Immunoglobulin G4-related disease (IgG4-RD) is a systemic fibroinflammatory disease with protean manifestations involving virtually any organ in the body. At initial clinical presentation, 1 or multiple organs may be involved. Initial descriptions focused on pancreatic disease. It has, however, become clear that IgG4-RD can cause an immune-mediated fibroinflammatory process, commonly manifesting as mass-like lesions, in various regions of the body including the thorax where any compartment can be involved. This pathologic process is characterized by infiltration of IgG4+ plasma cells and a propensity to fibrosis leading to organ dysfunction which can be prevented by early diagnosis and corticosteroid therapy.

Original languageEnglish (US)
Pages (from-to)569-578
Number of pages10
JournalClinics in Chest Medicine
Volume37
Issue number3
DOIs
StatePublished - Sep 1 2016

Keywords

  • Fibroinflammatory
  • Immunoglobulin G4
  • Interstitial lung disease
  • Lymphadenopathy
  • Pleuritis
  • Pseudotumor

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Fingerprint Dive into the research topics of 'Immunoglobulin G4-Related Disease and the Lung'. Together they form a unique fingerprint.

Cite this