Abstract
Childhood dermatomyositis is a multisystem autoimmune disease characterized by acute and chronic inflammatory infiltrate and vasculitis seen primarily in skin and muscle. The disease occurs in genetically susceptible individuals with a yet undescribed environmental trigger. Genetic associations in this disease demonstrate disease susceptibility as well as chronicity and severity and likely play a role in disease pathogenesis. The majority of the associations to date have been seen with the HLA alleles, with additional immune responsive and influential genes being increasingly investigated.
Original language | English (US) |
---|---|
Pages (from-to) | 212-215 |
Number of pages | 4 |
Journal | Current rheumatology reports |
Volume | 2 |
Issue number | 3 |
DOIs | |
State | Published - Jun 2000 |
ASJC Scopus subject areas
- Rheumatology