Immunoarchitectural patterns in nodal marginal zone B-cell lymphoma: A study of 51 cases

Mohamed E. Salama, Izidore S. Lossos, Roger A. Warnke, Yasodha Natkunam

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Nodal marginal zone lymphoma (NMZL) represents a rare and heterogeneous group that lacks markers specific for the diagnosis. We evaluated morphologic and immunoarchitectural features of 51 NMZLs, and the following immunostains were performed: CD20, CD21, CD23, CD5, CD3, CD43, CD10, Ki-67, BCL1, BCL2, BCL6, HGAL, and LMO2. Four immunoarchitectural patterns were evident: diffuse (38 [75%]), well-formed nodular/follicular (5 [10%]), interfollicular (7 [14%]), and perifollicular (1 [2%]). Additional features included a monocytoid component (36 [71%]), admixed large cells (20 [39%]), plasma cells (24 [47%]), compartmentalizing stromal sclerosis (13 [25%]), and prominent blood vessel sclerosis (10 [20%]). CD21 highlighted disrupted follicular dendritic cell meshwork in 35 (71%) of 49 cases, and CD43 coexpression was present in 10 (24%) of 42 cases. A panel of germinal center-associated markers was helpful in eliminating cases of diffuse follicle center lymphoma. Our results highlight the histologic and immunoarchitectural spectrum of NMZL and the usefulness of immunohistochemical analysis for CD43, CD23, CD21, BCL6, HGAL, and LMO2 in the diagnosis of NMZL.

Original languageEnglish (US)
Pages (from-to)39-49
Number of pages11
JournalAmerican journal of clinical pathology
Volume132
Issue number1
DOIs
StatePublished - Jul 2009

Keywords

  • Immunoarchitecture
  • Immunohistochemistry
  • Low-grade B-cell lymphoma
  • Monocytoid B cells
  • Nodal marginal zone lymphoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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