Immune promotion of epithelial-mesenchymal transition and generation of breast cancer stem cells

Jennifer M. Reiman, Keith L Knutson, Derek C Radisky

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Elements of the immune system act as intimate regulators of cancer progression, inhibiting early stages of tumor growth, through immunosurveillance while facilitating later stages of tumor progression. Recent findings have revealed that activated CD8 T cells can stimulate mammary epithelial tumor cells to undergo epithelial-mesenchymal transition (EMT) and to acquire the greatly increased tumorigenic capability and chemotherapeutic resistance of breast cancer stem cells (BCSC). These studies provide a window to understanding how BCSC arise and are maintained within tumors, and how to best target these processes for therapeutic benefit.

Original languageEnglish (US)
Pages (from-to)3005-3008
Number of pages4
JournalCancer Research
Volume70
Issue number8
DOIs
StatePublished - Apr 15 2010

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Epithelial-Mesenchymal Transition
Neoplastic Stem Cells
Breast Neoplasms
Neoplasms
Immunologic Monitoring
Immune System
Epithelial Cells
T-Lymphocytes
Growth
Therapeutics

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Immune promotion of epithelial-mesenchymal transition and generation of breast cancer stem cells. / Reiman, Jennifer M.; Knutson, Keith L; Radisky, Derek C.

In: Cancer Research, Vol. 70, No. 8, 15.04.2010, p. 3005-3008.

Research output: Contribution to journalArticle

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