Immune-mediated injury of virus-infected oligodendrocytes A model of multiple sclerosis

Moses Rodriguez, Larry R Pease, Chella S. David

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

The causes of primary demyelination in diseases such as multiple sclerosis are still unknown, but it is possible that immune attack triggered by virus infection may be responsible. Theiler's murine encephalitis is a popular animal model of demyelinating diseases, and in this article Moses Rodriguez and his colleagues describe a hypothetical scheme to explain differential susceptibility of inbred strains to infection. They propose a mechanism by which specific demyelination is produced when immune cells interact with viral antigen and major histocompatibility complex (MHC) antigens.

Original languageEnglish (US)
Pages (from-to)359-363
Number of pages5
JournalImmunology Today
Volume7
Issue number12
DOIs
StatePublished - 1986

Fingerprint

Oligodendroglia
Demyelinating Diseases
Multiple Sclerosis
Viruses
Wounds and Injuries
Histocompatibility Antigens
Viral Antigens
Virus Diseases
Encephalitis
Major Histocompatibility Complex
Animal Models
Infection

ASJC Scopus subject areas

  • Immunology

Cite this

Immune-mediated injury of virus-infected oligodendrocytes A model of multiple sclerosis. / Rodriguez, Moses; Pease, Larry R; David, Chella S.

In: Immunology Today, Vol. 7, No. 12, 1986, p. 359-363.

Research output: Contribution to journalArticle

Rodriguez, Moses ; Pease, Larry R ; David, Chella S. / Immune-mediated injury of virus-infected oligodendrocytes A model of multiple sclerosis. In: Immunology Today. 1986 ; Vol. 7, No. 12. pp. 359-363.
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