Immune-mediated injury of virus-infected oligodendrocytes A model of multiple sclerosis

Moses Rodriguez; Larry R. Pease; Chella S. David

doi:10.1016/0167-5699(86)90025-3

Immune-mediated injury of virus-infected oligodendrocytes A model of multiple sclerosis

Moses Rodriguez, Larry R. Pease, Chella S. David

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

The causes of primary demyelination in diseases such as multiple sclerosis are still unknown, but it is possible that immune attack triggered by virus infection may be responsible. Theiler's murine encephalitis is a popular animal model of demyelinating diseases, and in this article Moses Rodriguez and his colleagues describe a hypothetical scheme to explain differential susceptibility of inbred strains to infection. They propose a mechanism by which specific demyelination is produced when immune cells interact with viral antigen and major histocompatibility complex (MHC) antigens.

Original language	English (US)
Pages (from-to)	359-363
Number of pages	5
Journal	Immunology Today
Volume	7
Issue number	12
DOIs	https://doi.org/10.1016/0167-5699(86)90025-3
State	Published - Dec 1986

ASJC Scopus subject areas

Immunology

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10.1016/0167-5699(86)90025-3

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title = "Immune-mediated injury of virus-infected oligodendrocytes A model of multiple sclerosis",

abstract = "The causes of primary demyelination in diseases such as multiple sclerosis are still unknown, but it is possible that immune attack triggered by virus infection may be responsible. Theiler's murine encephalitis is a popular animal model of demyelinating diseases, and in this article Moses Rodriguez and his colleagues describe a hypothetical scheme to explain differential susceptibility of inbred strains to infection. They propose a mechanism by which specific demyelination is produced when immune cells interact with viral antigen and major histocompatibility complex (MHC) antigens.",

author = "Moses Rodriguez and Pease, {Larry R.} and David, {Chella S.}",

note = "Funding Information: Moses Rodriguez is the recipient of Teacher Investigator Award NS 00849 from the National Institutes of Health and is a Rappaport Scholar of the Mayo Foundation. Address reprint requests to Moses Rodriguez, M.D., Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA.",

year = "1986",

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AU - Rodriguez, Moses

AU - Pease, Larry R.

AU - David, Chella S.

N1 - Funding Information: Moses Rodriguez is the recipient of Teacher Investigator Award NS 00849 from the National Institutes of Health and is a Rappaport Scholar of the Mayo Foundation. Address reprint requests to Moses Rodriguez, M.D., Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA.

PY - 1986/12

Y1 - 1986/12

N2 - The causes of primary demyelination in diseases such as multiple sclerosis are still unknown, but it is possible that immune attack triggered by virus infection may be responsible. Theiler's murine encephalitis is a popular animal model of demyelinating diseases, and in this article Moses Rodriguez and his colleagues describe a hypothetical scheme to explain differential susceptibility of inbred strains to infection. They propose a mechanism by which specific demyelination is produced when immune cells interact with viral antigen and major histocompatibility complex (MHC) antigens.

AB - The causes of primary demyelination in diseases such as multiple sclerosis are still unknown, but it is possible that immune attack triggered by virus infection may be responsible. Theiler's murine encephalitis is a popular animal model of demyelinating diseases, and in this article Moses Rodriguez and his colleagues describe a hypothetical scheme to explain differential susceptibility of inbred strains to infection. They propose a mechanism by which specific demyelination is produced when immune cells interact with viral antigen and major histocompatibility complex (MHC) antigens.

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Immune-mediated injury of virus-infected oligodendrocytes A model of multiple sclerosis

Abstract

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