TY - JOUR
T1 - Immune Checkpoint Inhibition—Does It Cause Rheumatic Diseases? Mechanisms of Cancer-Associated Loss of Tolerance and Pathogenesis of Autoimmunity
AU - Thanarajasingam, Uma
AU - Abdel-Wahab, Noha
N1 - Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020/8
Y1 - 2020/8
N2 - Mechanisms of immune checkpoints and their role in autoimmunity are discussed in the context of immune checkpoint inhibitor (ICI) therapy for cancer. The updated clinical spectrum of immune-related adverse events (irAEs), with an in-depth discussion of rheumatic irAEs, is presented. The relationship between ICI-induced loss of self-tolerance in cancer and the implications for understanding of irAEs, rheumatic irAEs in particular, is overviewed.
AB - Mechanisms of immune checkpoints and their role in autoimmunity are discussed in the context of immune checkpoint inhibitor (ICI) therapy for cancer. The updated clinical spectrum of immune-related adverse events (irAEs), with an in-depth discussion of rheumatic irAEs, is presented. The relationship between ICI-induced loss of self-tolerance in cancer and the implications for understanding of irAEs, rheumatic irAEs in particular, is overviewed.
KW - Autoimmunity
KW - Immune checkpoint inhibitors
KW - Immune-related adverse events
KW - Rheumatic diseases
KW - Tolerance
UR - http://www.scopus.com/inward/record.url?scp=85086041459&partnerID=8YFLogxK
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U2 - 10.1016/j.rdc.2020.04.003
DO - 10.1016/j.rdc.2020.04.003
M3 - Review article
C2 - 32631606
AN - SCOPUS:85086041459
SN - 0889-857X
VL - 46
SP - 587
EP - 603
JO - Rheumatic Disease Clinics of North America
JF - Rheumatic Disease Clinics of North America
IS - 3
ER -