Imatinib-responsive hypereosinophilia in a patient with B cell ALL

Jamie Robyn, Pierre Noel, Iwona Wlodarska, Mamta Choksi, Patricia O'Neal, Diane C. Arthur, Cynthia Dunbar, Thomas B. Nutman, Amy D. Klion

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Hypereosinophilia is a rare presenting sign of acute lymphocytic leukemia. A 29-year-old male was diagnosed with idiopathic hypereosinophilic syndrome with respiratory symptoms. Although his peripheral blood eosinophilia decreased in response to treatment with imatinib mesylate, a follow-up bone marrow showed a diffuse infiltrate of myeloperoxidase-negative blasts. He was subsequently diagnosed with CD10 positive precursor B lymphoblastic leukemia. This case underscores the importance of follow-up bone marrow examination in patients who demonstrate imatinib mesylate-responsive eosinophilia.

Original languageEnglish (US)
Pages (from-to)2497-2501
Number of pages5
JournalLeukemia and Lymphoma
Volume45
Issue number12
DOIs
StatePublished - Dec 2004
Externally publishedYes

Fingerprint

Eosinophilia
Precursor Cell Lymphoblastic Leukemia-Lymphoma
B-Lymphocytes
Hypereosinophilic Syndrome
Bone Marrow Examination
Peroxidase
Bone Marrow
Imatinib Mesylate
Therapeutics

Keywords

  • ALL/Eo
  • Hypereosinophilic syndrome
  • Imatinib mesylate

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Robyn, J., Noel, P., Wlodarska, I., Choksi, M., O'Neal, P., Arthur, D. C., ... Klion, A. D. (2004). Imatinib-responsive hypereosinophilia in a patient with B cell ALL. Leukemia and Lymphoma, 45(12), 2497-2501. https://doi.org/10.1080/10428190400005288

Imatinib-responsive hypereosinophilia in a patient with B cell ALL. / Robyn, Jamie; Noel, Pierre; Wlodarska, Iwona; Choksi, Mamta; O'Neal, Patricia; Arthur, Diane C.; Dunbar, Cynthia; Nutman, Thomas B.; Klion, Amy D.

In: Leukemia and Lymphoma, Vol. 45, No. 12, 12.2004, p. 2497-2501.

Research output: Contribution to journalArticle

Robyn, J, Noel, P, Wlodarska, I, Choksi, M, O'Neal, P, Arthur, DC, Dunbar, C, Nutman, TB & Klion, AD 2004, 'Imatinib-responsive hypereosinophilia in a patient with B cell ALL', Leukemia and Lymphoma, vol. 45, no. 12, pp. 2497-2501. https://doi.org/10.1080/10428190400005288
Robyn J, Noel P, Wlodarska I, Choksi M, O'Neal P, Arthur DC et al. Imatinib-responsive hypereosinophilia in a patient with B cell ALL. Leukemia and Lymphoma. 2004 Dec;45(12):2497-2501. https://doi.org/10.1080/10428190400005288
Robyn, Jamie ; Noel, Pierre ; Wlodarska, Iwona ; Choksi, Mamta ; O'Neal, Patricia ; Arthur, Diane C. ; Dunbar, Cynthia ; Nutman, Thomas B. ; Klion, Amy D. / Imatinib-responsive hypereosinophilia in a patient with B cell ALL. In: Leukemia and Lymphoma. 2004 ; Vol. 45, No. 12. pp. 2497-2501.
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