Imatinib-responsive hypereosinophilia in a patient with B cell ALL

Jamie Robyn; Pierre Noel; Iwona Wlodarska; Mamta Choksi; Patricia O'Neal; Diane C. Arthur; Cynthia Dunbar; Thomas B. Nutman; Amy D. Klion

doi:10.1080/10428190400005288

Imatinib-responsive hypereosinophilia in a patient with B cell ALL

Jamie Robyn, Pierre Noel, Iwona Wlodarska, Mamta Choksi, Patricia O'Neal, Diane C. Arthur, Cynthia Dunbar, Thomas B. Nutman, Amy D. Klion

Hematology/Oncology

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Hypereosinophilia is a rare presenting sign of acute lymphocytic leukemia. A 29-year-old male was diagnosed with idiopathic hypereosinophilic syndrome with respiratory symptoms. Although his peripheral blood eosinophilia decreased in response to treatment with imatinib mesylate, a follow-up bone marrow showed a diffuse infiltrate of myeloperoxidase-negative blasts. He was subsequently diagnosed with CD10 positive precursor B lymphoblastic leukemia. This case underscores the importance of follow-up bone marrow examination in patients who demonstrate imatinib mesylate-responsive eosinophilia.

Original language	English (US)
Pages (from-to)	2497-2501
Number of pages	5
Journal	Leukemia and Lymphoma
Volume	45
Issue number	12
DOIs	https://doi.org/10.1080/10428190400005288
State	Published - Dec 2004

Keywords

ALL/Eo
Hypereosinophilic syndrome
Imatinib mesylate

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1080/10428190400005288

Cite this

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title = "Imatinib-responsive hypereosinophilia in a patient with B cell ALL",

abstract = "Hypereosinophilia is a rare presenting sign of acute lymphocytic leukemia. A 29-year-old male was diagnosed with idiopathic hypereosinophilic syndrome with respiratory symptoms. Although his peripheral blood eosinophilia decreased in response to treatment with imatinib mesylate, a follow-up bone marrow showed a diffuse infiltrate of myeloperoxidase-negative blasts. He was subsequently diagnosed with CD10 positive precursor B lymphoblastic leukemia. This case underscores the importance of follow-up bone marrow examination in patients who demonstrate imatinib mesylate-responsive eosinophilia.",

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T1 - Imatinib-responsive hypereosinophilia in a patient with B cell ALL

AU - Robyn, Jamie

AU - Noel, Pierre

AU - Wlodarska, Iwona

AU - Choksi, Mamta

AU - O'Neal, Patricia

AU - Arthur, Diane C.

AU - Dunbar, Cynthia

AU - Nutman, Thomas B.

AU - Klion, Amy D.

PY - 2004/12

Y1 - 2004/12

N2 - Hypereosinophilia is a rare presenting sign of acute lymphocytic leukemia. A 29-year-old male was diagnosed with idiopathic hypereosinophilic syndrome with respiratory symptoms. Although his peripheral blood eosinophilia decreased in response to treatment with imatinib mesylate, a follow-up bone marrow showed a diffuse infiltrate of myeloperoxidase-negative blasts. He was subsequently diagnosed with CD10 positive precursor B lymphoblastic leukemia. This case underscores the importance of follow-up bone marrow examination in patients who demonstrate imatinib mesylate-responsive eosinophilia.

AB - Hypereosinophilia is a rare presenting sign of acute lymphocytic leukemia. A 29-year-old male was diagnosed with idiopathic hypereosinophilic syndrome with respiratory symptoms. Although his peripheral blood eosinophilia decreased in response to treatment with imatinib mesylate, a follow-up bone marrow showed a diffuse infiltrate of myeloperoxidase-negative blasts. He was subsequently diagnosed with CD10 positive precursor B lymphoblastic leukemia. This case underscores the importance of follow-up bone marrow examination in patients who demonstrate imatinib mesylate-responsive eosinophilia.

KW - ALL/Eo

KW - Hypereosinophilic syndrome

KW - Imatinib mesylate

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Imatinib-responsive hypereosinophilia in a patient with B cell ALL

Abstract

Keywords

ASJC Scopus subject areas

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