Imatinib-responsive hypereosinophilia in a patient with B cell ALL

Jamie Robyn, Pierre Noel, Iwona Wlodarska, Mamta Choksi, Patricia O'Neal, Diane C. Arthur, Cynthia Dunbar, Thomas B. Nutman, Amy D. Klion

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Hypereosinophilia is a rare presenting sign of acute lymphocytic leukemia. A 29-year-old male was diagnosed with idiopathic hypereosinophilic syndrome with respiratory symptoms. Although his peripheral blood eosinophilia decreased in response to treatment with imatinib mesylate, a follow-up bone marrow showed a diffuse infiltrate of myeloperoxidase-negative blasts. He was subsequently diagnosed with CD10 positive precursor B lymphoblastic leukemia. This case underscores the importance of follow-up bone marrow examination in patients who demonstrate imatinib mesylate-responsive eosinophilia.

Original languageEnglish (US)
Pages (from-to)2497-2501
Number of pages5
JournalLeukemia and Lymphoma
Volume45
Issue number12
DOIs
StatePublished - Dec 1 2004

Keywords

  • ALL/Eo
  • Hypereosinophilic syndrome
  • Imatinib mesylate

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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