Imaging the response to deep brain stimulation in rodent using functional ultrasound

Rohit Nayak, Jeyeon Lee, Siobhan Chantigian, Mostafa Fatemi, Su Youne Chang, Azra Alizad

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

In this study, we explored the feasibility of using functional ultrasound (fUS) imaging to visualize cerebral activation associated with thalamic deep brain stimulation (DBS), in rodents. The ventrolateral (VL) thalamus was stimulated using electrical pulses of low and high frequencies of 10 and 100 Hz, respectively, and multiple voltages (1-7 V) and pulse widths (50-1500 μs). The fUS imaging demonstrated DBS-evoked activation of cerebral cortex based on changes of cerebral blood volume, specifically at the primary motor cortex (PMC). Low frequency stimulation (LFS) demonstrated significantly higher PMC activation compared to higher frequency stimulation (HFS), at intensities (5-7 V). Whereas, at lower intensities (1-3 V), only HFS demonstrated visible PMC activation. Further, LFS-evoked cerebral activation was was primarily located at the PMC. Our data presents the functionality and feasibility of fUS imaging as an investigational tool to identify brain areas associated with DBS. This preliminary study is an important stepping stone towards conducting real-time functional ultrasound imaging of DBS in awake and behaving animal models, which is of significant interest to the community for studying motor-related disorders.

Original languageEnglish (US)
Article number05LT01
JournalPhysics in medicine and biology
Volume66
Issue number5
DOIs
StatePublished - Mar 7 2021

Keywords

  • Cerebral hemodynamics
  • Deep brain stimulation
  • Functional ultrasound
  • Microvasculature imaging
  • Thalamus stimulation

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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