Imaging of myocardial fatty acid oxidation

Kieren J. Mather, Timothy R. DeGrado

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Myocardial fuel selection is a key feature of the health and function of the heart, with clear links between myocardial function and fuel selection and important impacts of fuel selection on ischemia tolerance. Radiopharmaceuticals provide uniquely valuable tools for in vivo, non-invasive assessment of these aspects of cardiac function and metabolism. Here we review the landscape of imaging probes developed to provide non-invasive assessment of myocardial fatty acid oxidation (MFAO). Also, we review the state of current knowledge that myocardial fatty acid imaging has helped establish of static and dynamic fuel selection that characterizes cardiac and cardiometabolic disease and the interplay between fuel selection and various aspects of cardiac function. This article is part of a Special Issue entitled: Heart Lipid Metabolism edited by G.D. Lopaschuk.

Original languageEnglish (US)
Pages (from-to)1535-1543
Number of pages9
JournalBiochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Volume1861
Issue number10
DOIs
StatePublished - Oct 1 2016

Keywords

  • Fatty acid oxidation
  • Fatty acid uptake
  • Metabolic imaging
  • Myocardial metabolism
  • PET
  • SPECT

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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