IgM natural autoantibodies in physiology and the treatment of disease

Mahboobeh Fereidan-Esfahani, Tarek Nayfeh, Arthur Warrington, Charles L Howe, Moses Rodriguez

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

Antibodies are vital components of the adaptive immune system for the recognition and response to foreign antigens. However, some antibodies recognize self-antigens in healthy individuals. These autoreactive antibodies may modulate innate immune functions. IgM natural autoantibodies (IgM-NAAs) are a class of primarily polyreactive immunoglobulins encoded by germline V-gene segments which exhibit low affinity but broad specificity to both foreign and self-antigens. Historically, these autoantibodies were closely associated with autoimmune disease. Nevertheless, not all human autoantibodies are pathogenic and compelling evidence indicates that IgM-NAAs may exert a spectrum of effects from injurious to protective depending upon cellular and molecular context. In this chapter, we review the current state of knowledge regarding the potential physiological and therapeutic roles of IgM-NAAs in different disease conditions such as atherosclerosis, cancer, and autoimmune disease. We also describe the discovery of two reparative IgM-NAAs by our laboratory and delineate their proposed mechanisms of action in central nervous system (CNS) disease.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages53-81
Number of pages29
DOIs
StatePublished - Jan 1 2019

Publication series

NameMethods in Molecular Biology
Volume1904
ISSN (Print)1064-3745

Fingerprint

Autoantibodies
Immunoglobulin M
Autoantigens
Autoimmune Diseases
Antibodies
Central Nervous System Diseases
Immunoglobulins
Immune System
Atherosclerosis
Antigens
Genes
Neoplasms

Keywords

  • Atherosclerosis
  • Autoantibody
  • B-1a
  • Cancer
  • Central nervous system
  • IgM
  • Multiple sclerosis
  • Natural
  • Oligodendrocyte
  • Physiology
  • Remyelination

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

Fereidan-Esfahani, M., Nayfeh, T., Warrington, A., Howe, C. L., & Rodriguez, M. (2019). IgM natural autoantibodies in physiology and the treatment of disease. In Methods in Molecular Biology (pp. 53-81). (Methods in Molecular Biology; Vol. 1904). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-8958-4_3

IgM natural autoantibodies in physiology and the treatment of disease. / Fereidan-Esfahani, Mahboobeh; Nayfeh, Tarek; Warrington, Arthur; Howe, Charles L; Rodriguez, Moses.

Methods in Molecular Biology. Humana Press Inc., 2019. p. 53-81 (Methods in Molecular Biology; Vol. 1904).

Research output: Chapter in Book/Report/Conference proceedingChapter

Fereidan-Esfahani, M, Nayfeh, T, Warrington, A, Howe, CL & Rodriguez, M 2019, IgM natural autoantibodies in physiology and the treatment of disease. in Methods in Molecular Biology. Methods in Molecular Biology, vol. 1904, Humana Press Inc., pp. 53-81. https://doi.org/10.1007/978-1-4939-8958-4_3
Fereidan-Esfahani M, Nayfeh T, Warrington A, Howe CL, Rodriguez M. IgM natural autoantibodies in physiology and the treatment of disease. In Methods in Molecular Biology. Humana Press Inc. 2019. p. 53-81. (Methods in Molecular Biology). https://doi.org/10.1007/978-1-4939-8958-4_3
Fereidan-Esfahani, Mahboobeh ; Nayfeh, Tarek ; Warrington, Arthur ; Howe, Charles L ; Rodriguez, Moses. / IgM natural autoantibodies in physiology and the treatment of disease. Methods in Molecular Biology. Humana Press Inc., 2019. pp. 53-81 (Methods in Molecular Biology).
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