IgG4-related tubulointerstitial nephritis

Lynn D. Cornell

doi:10.1038/ki.2010.342

IgG4-related tubulointerstitial nephritis

Lynn D. Cornell

Laboratory Medicine and Pathology

Research output: Contribution to journal › Comment/debate › peer-review

27 Scopus citations

Abstract

Tubulointerstitial nephritis (TIN) is a disease pattern with heterogeneous causes. Recently a specific subtype of autoimmune TIN, IgG4-related TIN, has been identified that is part of systemic IgG4-related disease/ autoimmune pancreatitis. On biopsy, this TIN shows an IgG4 plasma cell-rich infiltrate, akin to the pancreatic tissue findings in autoimmune pancreatitis, and may show tubulointerstitial immune complex deposits. Notably, some cases may be mass-forming. Recognition of this specific type of TIN can guide appropriate patient therapy.

Original language	English (US)
Pages (from-to)	951-953
Number of pages	3
Journal	Kidney international
Volume	78
Issue number	10
DOIs	https://doi.org/10.1038/ki.2010.342
State	Published - Nov 2010

ASJC Scopus subject areas

Nephrology

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abstract = "Tubulointerstitial nephritis (TIN) is a disease pattern with heterogeneous causes. Recently a specific subtype of autoimmune TIN, IgG4-related TIN, has been identified that is part of systemic IgG4-related disease/ autoimmune pancreatitis. On biopsy, this TIN shows an IgG4 plasma cell-rich infiltrate, akin to the pancreatic tissue findings in autoimmune pancreatitis, and may show tubulointerstitial immune complex deposits. Notably, some cases may be mass-forming. Recognition of this specific type of TIN can guide appropriate patient therapy.",

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AB - Tubulointerstitial nephritis (TIN) is a disease pattern with heterogeneous causes. Recently a specific subtype of autoimmune TIN, IgG4-related TIN, has been identified that is part of systemic IgG4-related disease/ autoimmune pancreatitis. On biopsy, this TIN shows an IgG4 plasma cell-rich infiltrate, akin to the pancreatic tissue findings in autoimmune pancreatitis, and may show tubulointerstitial immune complex deposits. Notably, some cases may be mass-forming. Recognition of this specific type of TIN can guide appropriate patient therapy.

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IgG4-related tubulointerstitial nephritis

Abstract

ASJC Scopus subject areas

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