IgG4-related paratesticular pseudotumor in a patient with autoimmune pancreatitis and retroperitoneal fibrosis: An extrapancreatic manifestation of IgG4-related disease

Phil A. Hart, Ann Moyer, Eunhee S. Yi, Marie C Hogan, Randall K. Pearson, Suresh T Chari

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

In this report, we describe the first case of a patient with an IgG4-related paratesticular pseudotumor. He had histologically proven autoimmune pancreatitis, then later developed a scrotal mass. The orchiectomy specimen revealed that this was a paratesticular pseudotumor with histopathologic and immunohistochemistry findings characteristic of IgG4-related disease. Paratesticular pseudotumors are uncommon causes of intrascrotal masses and have an unexplained pathogenesis. A variety of genitourinary manifestations of IgG4-related disease including IgG4-related tubulointerstitial nephritis, IgG4-related ureteral pseudotumors, and IgG4-related prostatitis has been previously reported. The current case highlights the need to have a high index of suspicion for IgG4 -tissue infiltration in patients with known autoimmune pancreatitis, particularly those with a pseudotumor.

Original languageEnglish (US)
Pages (from-to)2084-2087
Number of pages4
JournalHuman Pathology
Volume43
Issue number11
DOIs
StatePublished - Nov 2012

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Retroperitoneal Fibrosis
Pancreatitis
Immunoglobulin G
Interstitial Nephritis
Prostatitis
Orchiectomy
Immunohistochemistry

Keywords

  • Autoimmune pancreatitis
  • IgG4-related disease
  • Paratesticular
  • Pseudotumor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

IgG4-related paratesticular pseudotumor in a patient with autoimmune pancreatitis and retroperitoneal fibrosis : An extrapancreatic manifestation of IgG4-related disease. / Hart, Phil A.; Moyer, Ann; Yi, Eunhee S.; Hogan, Marie C; Pearson, Randall K.; Chari, Suresh T.

In: Human Pathology, Vol. 43, No. 11, 11.2012, p. 2084-2087.

Research output: Contribution to journalArticle

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