IgG4-related disease of the aortic valve: A report of two cases and review of the literature

Joseph Maleszewski, Henry D. Tazelaar, Heidi M. Horcher, Thomas J. Hinkamp, John V. Conte, James K. Porterfield, Marc K. Halushka

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

IgG4-related disease (IgG4-RD) is a relatively recently described disorder that can affect multiple organ systems, including the cardiovascular system. While most reported cases of cardiovascular involvement are of the aorta, usually the abdominal aorta, rare isolated reports of involvement of the heart proper have been described. Herein, we describe two cases of IgG4-RD involving the aortic valve. Each case was found to be associated with increased levels of IgG4 in the tissue and one case resulted in the subsequent discovery of IgG4-related pancreatitis.

Original languageEnglish (US)
Pages (from-to)56-59
Number of pages4
JournalCardiovascular Pathology
Volume24
Issue number1
DOIs
StatePublished - Jan 1 2015

Fingerprint

Aortic Valve
Immunoglobulin G
Abdominal Aorta
Cardiovascular System
Pancreatitis
Aorta

Keywords

  • Endocarditis
  • Immunologic
  • Plasma cells

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pathology and Forensic Medicine

Cite this

Maleszewski, J., Tazelaar, H. D., Horcher, H. M., Hinkamp, T. J., Conte, J. V., Porterfield, J. K., & Halushka, M. K. (2015). IgG4-related disease of the aortic valve: A report of two cases and review of the literature. Cardiovascular Pathology, 24(1), 56-59. https://doi.org/10.1016/j.carpath.2014.08.001

IgG4-related disease of the aortic valve : A report of two cases and review of the literature. / Maleszewski, Joseph; Tazelaar, Henry D.; Horcher, Heidi M.; Hinkamp, Thomas J.; Conte, John V.; Porterfield, James K.; Halushka, Marc K.

In: Cardiovascular Pathology, Vol. 24, No. 1, 01.01.2015, p. 56-59.

Research output: Contribution to journalArticle

Maleszewski, J, Tazelaar, HD, Horcher, HM, Hinkamp, TJ, Conte, JV, Porterfield, JK & Halushka, MK 2015, 'IgG4-related disease of the aortic valve: A report of two cases and review of the literature', Cardiovascular Pathology, vol. 24, no. 1, pp. 56-59. https://doi.org/10.1016/j.carpath.2014.08.001
Maleszewski, Joseph ; Tazelaar, Henry D. ; Horcher, Heidi M. ; Hinkamp, Thomas J. ; Conte, John V. ; Porterfield, James K. ; Halushka, Marc K. / IgG4-related disease of the aortic valve : A report of two cases and review of the literature. In: Cardiovascular Pathology. 2015 ; Vol. 24, No. 1. pp. 56-59.
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