IgG synthesis rate in evaluation of multiple sclerosis in a community hospital

Eric L. Matteson; David G. Flagler; Bruce W. Mesara

doi:10.1212/wnl.37.5.847

IgG synthesis rate in evaluation of multiple sclerosis in a community hospital

Eric L. Matteson, David G. Flagler, Bruce W. Mesara

Rheumatology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

We obtained CSF and serum from 21 patients with definite MS in a community hospital. Ninety percent of patients had an elevated IgG synthesis rate, comparable with the sensitivity of oligoclonal bands (0.95) or the IgG index (0.90) and better than the IgG% (0.47) in definite MS. We found that no area hospital routinely employs the IgG synthesis rate. The low-sensitivity IgG% and the dimensionless IgG index can be abandoned. The linear IgG synthesis rate and oligoclonal band scanning should be the CSF tests of choice.

Original language	English (US)
Pages (from-to)	847-849
Number of pages	3
Journal	Neurology
Volume	37
Issue number	5
DOIs	https://doi.org/10.1212/wnl.37.5.847
State	Published - May 1987

ASJC Scopus subject areas

Clinical Neurology

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AU - Flagler, David G.

AU - Mesara, Bruce W.

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N2 - We obtained CSF and serum from 21 patients with definite MS in a community hospital. Ninety percent of patients had an elevated IgG synthesis rate, comparable with the sensitivity of oligoclonal bands (0.95) or the IgG index (0.90) and better than the IgG% (0.47) in definite MS. We found that no area hospital routinely employs the IgG synthesis rate. The low-sensitivity IgG% and the dimensionless IgG index can be abandoned. The linear IgG synthesis rate and oligoclonal band scanning should be the CSF tests of choice.

AB - We obtained CSF and serum from 21 patients with definite MS in a community hospital. Ninety percent of patients had an elevated IgG synthesis rate, comparable with the sensitivity of oligoclonal bands (0.95) or the IgG index (0.90) and better than the IgG% (0.47) in definite MS. We found that no area hospital routinely employs the IgG synthesis rate. The low-sensitivity IgG% and the dimensionless IgG index can be abandoned. The linear IgG synthesis rate and oligoclonal band scanning should be the CSF tests of choice.

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IgG synthesis rate in evaluation of multiple sclerosis in a community hospital

Abstract

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