TY - JOUR
T1 - Idiopathic interstitial pneumonias
T2 - Diagnostic accuracy of thin-section CT in 129 patients
AU - Johkoh, Takeshi
AU - Müller, Nestor L.
AU - Cartier, Yannick
AU - Kavanagh, Peter V.
AU - Hartman, Thomas E.
AU - Akira, Masanori
AU - Ichikado, Kazuya
AU - Ando, Masayuki
AU - Nakamura, Hironobu
PY - 1999/5
Y1 - 1999/5
N2 - PURPOSE: To determine whether idiopathic interstitial pneumonias can be differentiated on the basis of the pattern and distribution of abnormalities at thin-section computed tomography (CT). MATERIALS AND METHODS: Thin- section CT scans in 129 patients with histologically proved idiopathic interstitial pneumonia (35 with usual interstitial pneumonia [UIP], 24 with bronchiolitis obliterans organizing pneumonia [BOOP], 23 with desquamative interstitial pneumonia [DIP], 20 with acute interstitial pneumonia [AIP], and 27 with nonspecific interstitial pneumonia and fibrosis [NIPF] were independently assessed by two observers without knowledge of clinical or histologic data. The observers recorded the abnormalities, diagnosis, and degree of confidence in their diagnosis. Differential diagnosis was limited to the five types of idiopathic interstitial pneumonia. RESULTS: The two observers made a correct diagnosis, on average, in 74 (57%) cases. On average, the correct diagnosis was made in 25 (71%) cases of UIP, 19 (79%) of BOOP, 14.5 (63%) of DIP, 13 (65%) of AIP, and 2.5 (9%) of NIPF. The two observers made a correct diagnosis with a high degree of confidence in 50 (39%) readings. There was moderate agreement between the observers for the correct diagnosis (κ = 0.55) and for the correct diagnosis with a high degree of confidence (κ = 0.65). CONCLUSION: Except for NIPF, the various subtypes of idiopathic interstitial pneumonias often have a characteristic appearance that allows differentiation at thin-section CT.
AB - PURPOSE: To determine whether idiopathic interstitial pneumonias can be differentiated on the basis of the pattern and distribution of abnormalities at thin-section computed tomography (CT). MATERIALS AND METHODS: Thin- section CT scans in 129 patients with histologically proved idiopathic interstitial pneumonia (35 with usual interstitial pneumonia [UIP], 24 with bronchiolitis obliterans organizing pneumonia [BOOP], 23 with desquamative interstitial pneumonia [DIP], 20 with acute interstitial pneumonia [AIP], and 27 with nonspecific interstitial pneumonia and fibrosis [NIPF] were independently assessed by two observers without knowledge of clinical or histologic data. The observers recorded the abnormalities, diagnosis, and degree of confidence in their diagnosis. Differential diagnosis was limited to the five types of idiopathic interstitial pneumonia. RESULTS: The two observers made a correct diagnosis, on average, in 74 (57%) cases. On average, the correct diagnosis was made in 25 (71%) cases of UIP, 19 (79%) of BOOP, 14.5 (63%) of DIP, 13 (65%) of AIP, and 2.5 (9%) of NIPF. The two observers made a correct diagnosis with a high degree of confidence in 50 (39%) readings. There was moderate agreement between the observers for the correct diagnosis (κ = 0.55) and for the correct diagnosis with a high degree of confidence (κ = 0.65). CONCLUSION: Except for NIPF, the various subtypes of idiopathic interstitial pneumonias often have a characteristic appearance that allows differentiation at thin-section CT.
KW - Bronchiolitis obliterans organizing pneumonia
KW - Lung, CT
KW - Pneumonia, acute interstitial
KW - Pneumonia, desquamative interstitial
KW - Pneumonia, nonspecific interstitial and fibrosis
KW - Pneumonia, usual interstitial
UR - http://www.scopus.com/inward/record.url?scp=0345593619&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0345593619&partnerID=8YFLogxK
U2 - 10.1148/radiology.211.2.r99ma01555
DO - 10.1148/radiology.211.2.r99ma01555
M3 - Article
C2 - 10228542
AN - SCOPUS:0345593619
SN - 0033-8419
VL - 211
SP - 555
EP - 560
JO - Radiology
JF - Radiology
IS - 2
ER -