TY - JOUR
T1 - Identifying melanoma patients with 1-3 brain metastases who may benefit from whole-brain irradiation in addition to radiosurgery
AU - Huttenlocher, Stefan
AU - Sehmisch, Lena
AU - Schild, Steven E.
AU - Blank, Oliver
AU - Hornung, Dagmar
AU - Rades, Dirk
N1 - Publisher Copyright:
© 2014, International Institute of Anticancer Research. All rights reserved.
PY - 2014/10/1
Y1 - 2014/10/1
N2 - Background/Aim: To develop a tool for estimating the risk of developing new cerebral lesions in 69 melanoma patients receiving radiosurgery for 1-3 cerebral metastases. Patients and Methods: Ten factors were investigated: lactate dehydrogenase (LDH), radiosurgery dose, age, gender, performance status, maximum diameter, location and number of cerebral lesions, extra-cranial spread, time between melanoma diagnosis and radiosurgery. Two factors, number of lesions and extra-cranial spread, were included in the tool. Scoring points were achieved by dividing the 6-month rate of freedom from new cerebral lesions by 10. Results: Sum scores were 9, 11, 12 or 14 points. Six-month rates of freedom from new brain metastases were 28%, 63%, 59% and 92% (p=0.002). Three prognostic groups were designed: A (9 points), B (11-12 points) and C (14 points). Freedom from new cerebral lesion rates were 28%, 60% and 92% (p<0.001). Conclusion: Group A and B patients should be considered for additional whole-brain radiotherapy (WBRT).
AB - Background/Aim: To develop a tool for estimating the risk of developing new cerebral lesions in 69 melanoma patients receiving radiosurgery for 1-3 cerebral metastases. Patients and Methods: Ten factors were investigated: lactate dehydrogenase (LDH), radiosurgery dose, age, gender, performance status, maximum diameter, location and number of cerebral lesions, extra-cranial spread, time between melanoma diagnosis and radiosurgery. Two factors, number of lesions and extra-cranial spread, were included in the tool. Scoring points were achieved by dividing the 6-month rate of freedom from new cerebral lesions by 10. Results: Sum scores were 9, 11, 12 or 14 points. Six-month rates of freedom from new brain metastases were 28%, 63%, 59% and 92% (p=0.002). Three prognostic groups were designed: A (9 points), B (11-12 points) and C (14 points). Freedom from new cerebral lesion rates were 28%, 60% and 92% (p<0.001). Conclusion: Group A and B patients should be considered for additional whole-brain radiotherapy (WBRT).
KW - Melanoma
KW - New brain metastases
KW - Predictive score
KW - Radiosurgery
KW - Whole-brain irradiation.
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M3 - Article
C2 - 25275060
AN - SCOPUS:84917710462
SN - 0250-7005
VL - 34
SP - 5589
EP - 5592
JO - Anticancer research
JF - Anticancer research
IS - 10
ER -