Identification of seven new prostate cancer susceptibility loci through a genome-wide association study

Rosalind A. Eeles, Zsofia Kote-Jarai, Ali Amin Al Olama, Graham G. Giles, Michelle Guy, Gianluca Severi, Kenneth Muir, John L. Hopper, Brian E. Henderson, Christopher A. Haiman, Johanna Schleutker, Freddie C. Hamdy, David E. Neal, Jenny L. Donovan, Janet L. Stanford, Elaine A. Ostrander, Sue A. Ingles, Esther M. John, Stephen N Thibodeau, Daniel J SchaidJong Y. Park, Amanda Spurdle, Judith Clements, Joanne L. Dickinson, Christiane Maier, Walther Vogel, Thilo Dörk, Timothy R. Rebbeck, Kathleen A. Cooney, Lisa Cannon-Albright, Pierre O. Chappuis, Pierre Hutter, Maurice Zeegers, Radka Kaneva, Hong Wei Zhang, Yong Jie Lu, William D. Foulkes, Dallas R. English, Daniel A. Leongamornlert, Malgorzata Tymrakiewicz, Jonathan Morrison, Audrey T. Ardern-Jones, Amanda L. Hall, Lynne T. O'Brien, Rosemary A. Wilkinson, Edward J. Saunders, Elizabeth C. Page, Emma J. Sawyer, Stephen M. Edwards, David P. Dearnaley, Alan Horwich, Robert A. Huddart, Vincent S. Khoo, Christopher C. Parker, Nicholas Van As, Christopher J. Woodhouse, Alan Thompson, Tim Christmas, Chris Ogden, Colin S. Cooper, Melissa C. Southey, Artitaya Lophatananon, Jo Fen Liu, Laurence N. Kolonel, Loic Le Marchand, Tiina Wahlfors, Teuvo L. Tammela, Anssi Auvinen, Sarah J. Lewis, Angela Cox, Liesel M. Fitzgerald, Joseph S. Koopmeiners, Danielle M. Karyadi, Erika M. Kwon, Mariana C. Stern, Roman Corral, Amit D. Joshi, Ahva Shahabi, Shannon K. McDonnell, Thomas A. Sellers, Julio Pow-Sang, Suzanne Chambers, Joanne Aitken, R. A. Gardiner, Jyotsna Batra, Mary Anne Kedda, Felicity Lose, Andrea Polanowski, Briony Patterson, Jürgen Serth, Andreas Meyer, Manuel Luedeke, Klara Stefflova, Anna M. Ray, Ethan M. Lange, Jim Farnham, Humera Khan, Chavdar Slavov, Atanaska Mitkova, Guangwen Cao, Douglas F. Easton

Research output: Contribution to journalArticle

328 Citations (Scopus)

Abstract

Prostate cancer (PrCa) is the most frequently diagnosed cancer in males in developed countries. To identify common PrCa susceptibility alleles, we previously conducted a genome-wide association study in which 541,129 SNPs were genotyped in 1,854 PrCa cases with clinically detected disease and in 1,894 controls. We have now extended the study to evaluate promising associations in a second stage in which we genotyped 43,671 SNPs in 3,650 PrCa cases and 3,940 controls and in a third stage involving an additional 16,229 cases and 14,821 controls from 21 studies. In addition to replicating previous associations, we identified seven new prostate cancer susceptibility loci on chromosomes 2, 4, 8, 11 and 22 (with P = 1.6 × 10 8 to P = 2.7 × 10 33).

Original languageEnglish (US)
Pages (from-to)1116-1121
Number of pages6
JournalNature Genetics
Volume41
Issue number10
DOIs
StatePublished - Oct 2009

Fingerprint

Genome-Wide Association Study
Prostatic Neoplasms
Single Nucleotide Polymorphism
Chromosomes, Human, Pair 4
Chromosomes, Human, Pair 2
Developed Countries
Alleles
Neoplasms

ASJC Scopus subject areas

  • Genetics

Cite this

Eeles, R. A., Kote-Jarai, Z., Al Olama, A. A., Giles, G. G., Guy, M., Severi, G., ... Easton, D. F. (2009). Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Nature Genetics, 41(10), 1116-1121. https://doi.org/10.1038/ng.450

Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. / Eeles, Rosalind A.; Kote-Jarai, Zsofia; Al Olama, Ali Amin; Giles, Graham G.; Guy, Michelle; Severi, Gianluca; Muir, Kenneth; Hopper, John L.; Henderson, Brian E.; Haiman, Christopher A.; Schleutker, Johanna; Hamdy, Freddie C.; Neal, David E.; Donovan, Jenny L.; Stanford, Janet L.; Ostrander, Elaine A.; Ingles, Sue A.; John, Esther M.; Thibodeau, Stephen N; Schaid, Daniel J; Park, Jong Y.; Spurdle, Amanda; Clements, Judith; Dickinson, Joanne L.; Maier, Christiane; Vogel, Walther; Dörk, Thilo; Rebbeck, Timothy R.; Cooney, Kathleen A.; Cannon-Albright, Lisa; Chappuis, Pierre O.; Hutter, Pierre; Zeegers, Maurice; Kaneva, Radka; Zhang, Hong Wei; Lu, Yong Jie; Foulkes, William D.; English, Dallas R.; Leongamornlert, Daniel A.; Tymrakiewicz, Malgorzata; Morrison, Jonathan; Ardern-Jones, Audrey T.; Hall, Amanda L.; O'Brien, Lynne T.; Wilkinson, Rosemary A.; Saunders, Edward J.; Page, Elizabeth C.; Sawyer, Emma J.; Edwards, Stephen M.; Dearnaley, David P.; Horwich, Alan; Huddart, Robert A.; Khoo, Vincent S.; Parker, Christopher C.; Van As, Nicholas; Woodhouse, Christopher J.; Thompson, Alan; Christmas, Tim; Ogden, Chris; Cooper, Colin S.; Southey, Melissa C.; Lophatananon, Artitaya; Liu, Jo Fen; Kolonel, Laurence N.; Le Marchand, Loic; Wahlfors, Tiina; Tammela, Teuvo L.; Auvinen, Anssi; Lewis, Sarah J.; Cox, Angela; Fitzgerald, Liesel M.; Koopmeiners, Joseph S.; Karyadi, Danielle M.; Kwon, Erika M.; Stern, Mariana C.; Corral, Roman; Joshi, Amit D.; Shahabi, Ahva; McDonnell, Shannon K.; Sellers, Thomas A.; Pow-Sang, Julio; Chambers, Suzanne; Aitken, Joanne; Gardiner, R. A.; Batra, Jyotsna; Kedda, Mary Anne; Lose, Felicity; Polanowski, Andrea; Patterson, Briony; Serth, Jürgen; Meyer, Andreas; Luedeke, Manuel; Stefflova, Klara; Ray, Anna M.; Lange, Ethan M.; Farnham, Jim; Khan, Humera; Slavov, Chavdar; Mitkova, Atanaska; Cao, Guangwen; Easton, Douglas F.

In: Nature Genetics, Vol. 41, No. 10, 10.2009, p. 1116-1121.

Research output: Contribution to journalArticle

Eeles, RA, Kote-Jarai, Z, Al Olama, AA, Giles, GG, Guy, M, Severi, G, Muir, K, Hopper, JL, Henderson, BE, Haiman, CA, Schleutker, J, Hamdy, FC, Neal, DE, Donovan, JL, Stanford, JL, Ostrander, EA, Ingles, SA, John, EM, Thibodeau, SN, Schaid, DJ, Park, JY, Spurdle, A, Clements, J, Dickinson, JL, Maier, C, Vogel, W, Dörk, T, Rebbeck, TR, Cooney, KA, Cannon-Albright, L, Chappuis, PO, Hutter, P, Zeegers, M, Kaneva, R, Zhang, HW, Lu, YJ, Foulkes, WD, English, DR, Leongamornlert, DA, Tymrakiewicz, M, Morrison, J, Ardern-Jones, AT, Hall, AL, O'Brien, LT, Wilkinson, RA, Saunders, EJ, Page, EC, Sawyer, EJ, Edwards, SM, Dearnaley, DP, Horwich, A, Huddart, RA, Khoo, VS, Parker, CC, Van As, N, Woodhouse, CJ, Thompson, A, Christmas, T, Ogden, C, Cooper, CS, Southey, MC, Lophatananon, A, Liu, JF, Kolonel, LN, Le Marchand, L, Wahlfors, T, Tammela, TL, Auvinen, A, Lewis, SJ, Cox, A, Fitzgerald, LM, Koopmeiners, JS, Karyadi, DM, Kwon, EM, Stern, MC, Corral, R, Joshi, AD, Shahabi, A, McDonnell, SK, Sellers, TA, Pow-Sang, J, Chambers, S, Aitken, J, Gardiner, RA, Batra, J, Kedda, MA, Lose, F, Polanowski, A, Patterson, B, Serth, J, Meyer, A, Luedeke, M, Stefflova, K, Ray, AM, Lange, EM, Farnham, J, Khan, H, Slavov, C, Mitkova, A, Cao, G & Easton, DF 2009, 'Identification of seven new prostate cancer susceptibility loci through a genome-wide association study', Nature Genetics, vol. 41, no. 10, pp. 1116-1121. https://doi.org/10.1038/ng.450
Eeles RA, Kote-Jarai Z, Al Olama AA, Giles GG, Guy M, Severi G et al. Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Nature Genetics. 2009 Oct;41(10):1116-1121. https://doi.org/10.1038/ng.450
Eeles, Rosalind A. ; Kote-Jarai, Zsofia ; Al Olama, Ali Amin ; Giles, Graham G. ; Guy, Michelle ; Severi, Gianluca ; Muir, Kenneth ; Hopper, John L. ; Henderson, Brian E. ; Haiman, Christopher A. ; Schleutker, Johanna ; Hamdy, Freddie C. ; Neal, David E. ; Donovan, Jenny L. ; Stanford, Janet L. ; Ostrander, Elaine A. ; Ingles, Sue A. ; John, Esther M. ; Thibodeau, Stephen N ; Schaid, Daniel J ; Park, Jong Y. ; Spurdle, Amanda ; Clements, Judith ; Dickinson, Joanne L. ; Maier, Christiane ; Vogel, Walther ; Dörk, Thilo ; Rebbeck, Timothy R. ; Cooney, Kathleen A. ; Cannon-Albright, Lisa ; Chappuis, Pierre O. ; Hutter, Pierre ; Zeegers, Maurice ; Kaneva, Radka ; Zhang, Hong Wei ; Lu, Yong Jie ; Foulkes, William D. ; English, Dallas R. ; Leongamornlert, Daniel A. ; Tymrakiewicz, Malgorzata ; Morrison, Jonathan ; Ardern-Jones, Audrey T. ; Hall, Amanda L. ; O'Brien, Lynne T. ; Wilkinson, Rosemary A. ; Saunders, Edward J. ; Page, Elizabeth C. ; Sawyer, Emma J. ; Edwards, Stephen M. ; Dearnaley, David P. ; Horwich, Alan ; Huddart, Robert A. ; Khoo, Vincent S. ; Parker, Christopher C. ; Van As, Nicholas ; Woodhouse, Christopher J. ; Thompson, Alan ; Christmas, Tim ; Ogden, Chris ; Cooper, Colin S. ; Southey, Melissa C. ; Lophatananon, Artitaya ; Liu, Jo Fen ; Kolonel, Laurence N. ; Le Marchand, Loic ; Wahlfors, Tiina ; Tammela, Teuvo L. ; Auvinen, Anssi ; Lewis, Sarah J. ; Cox, Angela ; Fitzgerald, Liesel M. ; Koopmeiners, Joseph S. ; Karyadi, Danielle M. ; Kwon, Erika M. ; Stern, Mariana C. ; Corral, Roman ; Joshi, Amit D. ; Shahabi, Ahva ; McDonnell, Shannon K. ; Sellers, Thomas A. ; Pow-Sang, Julio ; Chambers, Suzanne ; Aitken, Joanne ; Gardiner, R. A. ; Batra, Jyotsna ; Kedda, Mary Anne ; Lose, Felicity ; Polanowski, Andrea ; Patterson, Briony ; Serth, Jürgen ; Meyer, Andreas ; Luedeke, Manuel ; Stefflova, Klara ; Ray, Anna M. ; Lange, Ethan M. ; Farnham, Jim ; Khan, Humera ; Slavov, Chavdar ; Mitkova, Atanaska ; Cao, Guangwen ; Easton, Douglas F. / Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. In: Nature Genetics. 2009 ; Vol. 41, No. 10. pp. 1116-1121.
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AU - Eeles, Rosalind A.

AU - Kote-Jarai, Zsofia

AU - Al Olama, Ali Amin

AU - Giles, Graham G.

AU - Guy, Michelle

AU - Severi, Gianluca

AU - Muir, Kenneth

AU - Hopper, John L.

AU - Henderson, Brian E.

AU - Haiman, Christopher A.

AU - Schleutker, Johanna

AU - Hamdy, Freddie C.

AU - Neal, David E.

AU - Donovan, Jenny L.

AU - Stanford, Janet L.

AU - Ostrander, Elaine A.

AU - Ingles, Sue A.

AU - John, Esther M.

AU - Thibodeau, Stephen N

AU - Schaid, Daniel J

AU - Park, Jong Y.

AU - Spurdle, Amanda

AU - Clements, Judith

AU - Dickinson, Joanne L.

AU - Maier, Christiane

AU - Vogel, Walther

AU - Dörk, Thilo

AU - Rebbeck, Timothy R.

AU - Cooney, Kathleen A.

AU - Cannon-Albright, Lisa

AU - Chappuis, Pierre O.

AU - Hutter, Pierre

AU - Zeegers, Maurice

AU - Kaneva, Radka

AU - Zhang, Hong Wei

AU - Lu, Yong Jie

AU - Foulkes, William D.

AU - English, Dallas R.

AU - Leongamornlert, Daniel A.

AU - Tymrakiewicz, Malgorzata

AU - Morrison, Jonathan

AU - Ardern-Jones, Audrey T.

AU - Hall, Amanda L.

AU - O'Brien, Lynne T.

AU - Wilkinson, Rosemary A.

AU - Saunders, Edward J.

AU - Page, Elizabeth C.

AU - Sawyer, Emma J.

AU - Edwards, Stephen M.

AU - Dearnaley, David P.

AU - Horwich, Alan

AU - Huddart, Robert A.

AU - Khoo, Vincent S.

AU - Parker, Christopher C.

AU - Van As, Nicholas

AU - Woodhouse, Christopher J.

AU - Thompson, Alan

AU - Christmas, Tim

AU - Ogden, Chris

AU - Cooper, Colin S.

AU - Southey, Melissa C.

AU - Lophatananon, Artitaya

AU - Liu, Jo Fen

AU - Kolonel, Laurence N.

AU - Le Marchand, Loic

AU - Wahlfors, Tiina

AU - Tammela, Teuvo L.

AU - Auvinen, Anssi

AU - Lewis, Sarah J.

AU - Cox, Angela

AU - Fitzgerald, Liesel M.

AU - Koopmeiners, Joseph S.

AU - Karyadi, Danielle M.

AU - Kwon, Erika M.

AU - Stern, Mariana C.

AU - Corral, Roman

AU - Joshi, Amit D.

AU - Shahabi, Ahva

AU - McDonnell, Shannon K.

AU - Sellers, Thomas A.

AU - Pow-Sang, Julio

AU - Chambers, Suzanne

AU - Aitken, Joanne

AU - Gardiner, R. A.

AU - Batra, Jyotsna

AU - Kedda, Mary Anne

AU - Lose, Felicity

AU - Polanowski, Andrea

AU - Patterson, Briony

AU - Serth, Jürgen

AU - Meyer, Andreas

AU - Luedeke, Manuel

AU - Stefflova, Klara

AU - Ray, Anna M.

AU - Lange, Ethan M.

AU - Farnham, Jim

AU - Khan, Humera

AU - Slavov, Chavdar

AU - Mitkova, Atanaska

AU - Cao, Guangwen

AU - Easton, Douglas F.

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AB - Prostate cancer (PrCa) is the most frequently diagnosed cancer in males in developed countries. To identify common PrCa susceptibility alleles, we previously conducted a genome-wide association study in which 541,129 SNPs were genotyped in 1,854 PrCa cases with clinically detected disease and in 1,894 controls. We have now extended the study to evaluate promising associations in a second stage in which we genotyped 43,671 SNPs in 3,650 PrCa cases and 3,940 controls and in a third stage involving an additional 16,229 cases and 14,821 controls from 21 studies. In addition to replicating previous associations, we identified seven new prostate cancer susceptibility loci on chromosomes 2, 4, 8, 11 and 22 (with P = 1.6 × 10 8 to P = 2.7 × 10 33).

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