Identification of seven new prostate cancer susceptibility loci through a genome-wide association study

Rosalind A. Eeles; Zsofia Kote-Jarai; Ali Amin Al Olama; Graham G. Giles; Michelle Guy; Gianluca Severi; Kenneth Muir; John L. Hopper; Brian E. Henderson; Christopher A. Haiman; Johanna Schleutker; Freddie C. Hamdy; David E. Neal; Jenny L. Donovan; Janet L. Stanford; Elaine A. Ostrander; Sue A. Ingles; Esther M. John; Stephen N. Thibodeau; Daniel Schaid; Jong Y. Park; Amanda Spurdle; Judith Clements; Joanne L. Dickinson; Christiane Maier; Walther Vogel; Thilo Dörk; Timothy R. Rebbeck; Kathleen A. Cooney; Lisa Cannon-Albright; Pierre O. Chappuis; Pierre Hutter; Maurice Zeegers; Radka Kaneva; Hong Wei Zhang; Yong Jie Lu; William D. Foulkes; Dallas R. English; Daniel A. Leongamornlert; Malgorzata Tymrakiewicz; Jonathan Morrison; Audrey T. Ardern-Jones; Amanda L. Hall; Lynne T. O'Brien; Rosemary A. Wilkinson; Edward J. Saunders; Elizabeth C. Page; Emma J. Sawyer; Stephen M. Edwards; David P. Dearnaley; Alan Horwich; Robert A. Huddart; Vincent S. Khoo; Christopher C. Parker; Nicholas Van As; Christopher J. Woodhouse; Alan Thompson; Tim Christmas; Chris Ogden; Colin S. Cooper; Melissa C. Southey; Artitaya Lophatananon; Jo Fen Liu; Laurence N. Kolonel; Loic Le Marchand; Tiina Wahlfors; Teuvo L. Tammela; Anssi Auvinen; Sarah J. Lewis; Angela Cox; Liesel M. Fitzgerald; Joseph S. Koopmeiners; Danielle M. Karyadi; Erika M. Kwon; Mariana C. Stern; Roman Corral; Amit D. Joshi; Ahva Shahabi; Shannon K. McDonnell; Thomas A. Sellers; Julio Pow-Sang; Suzanne Chambers; Joanne Aitken; R. A. Gardiner; Jyotsna Batra; Mary Anne Kedda; Felicity Lose; Andrea Polanowski; Briony Patterson; Jürgen Serth; Andreas Meyer; Manuel Luedeke; Klara Stefflova; Anna M. Ray; Ethan M. Lange; Jim Farnham; Humera Khan; Chavdar Slavov; Atanaska Mitkova; Guangwen Cao; Douglas F. Easton

doi:10.1038/ng.450

Identification of seven new prostate cancer susceptibility loci through a genome-wide association study

Rosalind A. Eeles, Zsofia Kote-Jarai, Ali Amin Al Olama, Graham G. Giles, Michelle Guy, Gianluca Severi, Kenneth Muir, John L. Hopper, Brian E. Henderson, Christopher A. Haiman, Johanna Schleutker, Freddie C. Hamdy, David E. Neal, Jenny L. Donovan, Janet L. Stanford, Elaine A. Ostrander, Sue A. Ingles, Esther M. John, Stephen N. Thibodeau, Daniel SchaidJong Y. Park, Amanda Spurdle, Judith Clements, Joanne L. Dickinson, Christiane Maier, Walther Vogel, Thilo Dörk, Timothy R. Rebbeck, Kathleen A. Cooney, Lisa Cannon-Albright, Pierre O. Chappuis, Pierre Hutter, Maurice Zeegers, Radka Kaneva, Hong Wei Zhang, Yong Jie Lu, William D. Foulkes, Dallas R. English, Daniel A. Leongamornlert, Malgorzata Tymrakiewicz, Jonathan Morrison, Audrey T. Ardern-Jones, Amanda L. Hall, Lynne T. O'Brien, Rosemary A. Wilkinson, Edward J. Saunders, Elizabeth C. Page, Emma J. Sawyer, Stephen M. Edwards, David P. Dearnaley, Alan Horwich, Robert A. Huddart, Vincent S. Khoo, Christopher C. Parker, Nicholas Van As, Christopher J. Woodhouse, Alan Thompson, Tim Christmas, Chris Ogden, Colin S. Cooper, Melissa C. Southey, Artitaya Lophatananon, Jo Fen Liu, Laurence N. Kolonel, Loic Le Marchand, Tiina Wahlfors, Teuvo L. Tammela, Anssi Auvinen, Sarah J. Lewis, Angela Cox, Liesel M. Fitzgerald, Joseph S. Koopmeiners, Danielle M. Karyadi, Erika M. Kwon, Mariana C. Stern, Roman Corral, Amit D. Joshi, Ahva Shahabi, Shannon K. McDonnell, Thomas A. Sellers, Julio Pow-Sang, Suzanne Chambers, Joanne Aitken, R. A. Gardiner, Jyotsna Batra, Mary Anne Kedda, Felicity Lose, Andrea Polanowski, Briony Patterson, Jürgen Serth, Andreas Meyer, Manuel Luedeke, Klara Stefflova, Anna M. Ray, Ethan M. Lange, Jim Farnham, Humera Khan, Chavdar Slavov, Atanaska Mitkova, Guangwen Cao, Douglas F. Easton

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Abstract

Prostate cancer (PrCa) is the most frequently diagnosed cancer in males in developed countries. To identify common PrCa susceptibility alleles, we previously conducted a genome-wide association study in which 541,129 SNPs were genotyped in 1,854 PrCa cases with clinically detected disease and in 1,894 controls. We have now extended the study to evaluate promising associations in a second stage in which we genotyped 43,671 SNPs in 3,650 PrCa cases and 3,940 controls and in a third stage involving an additional 16,229 cases and 14,821 controls from 21 studies. In addition to replicating previous associations, we identified seven new prostate cancer susceptibility loci on chromosomes 2, 4, 8, 11 and 22 (with P = 1.6 × 10 8 to P = 2.7 × 10 33).

Original language	English (US)
Pages (from-to)	1116-1121
Number of pages	6
Journal	Nature Genetics
Volume	41
Issue number	10
DOIs	https://doi.org/10.1038/ng.450
State	Published - Oct 2009

ASJC Scopus subject areas

Genetics

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Eeles, R. A., Kote-Jarai, Z., Al Olama, A. A., Giles, G. G., Guy, M., Severi, G., Muir, K., Hopper, J. L., Henderson, B. E., Haiman, C. A., Schleutker, J., Hamdy, F. C., Neal, D. E., Donovan, J. L., Stanford, J. L., Ostrander, E. A., Ingles, S. A., John, E. M., Thibodeau, S. N., ... Easton, D. F. (2009). Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Nature Genetics, 41(10), 1116-1121. https://doi.org/10.1038/ng.450

Eeles, RA, Kote-Jarai, Z, Al Olama, AA, Giles, GG, Guy, M, Severi, G, Muir, K, Hopper, JL, Henderson, BE, Haiman, CA, Schleutker, J, Hamdy, FC, Neal, DE, Donovan, JL, Stanford, JL, Ostrander, EA, Ingles, SA, John, EM, Thibodeau, SN , Schaid, D, Park, JY, Spurdle, A, Clements, J, Dickinson, JL, Maier, C, Vogel, W, Dörk, T, Rebbeck, TR, Cooney, KA, Cannon-Albright, L, Chappuis, PO, Hutter, P, Zeegers, M, Kaneva, R, Zhang, HW, Lu, YJ, Foulkes, WD, English, DR, Leongamornlert, DA, Tymrakiewicz, M, Morrison, J, Ardern-Jones, AT, Hall, AL, O'Brien, LT, Wilkinson, RA, Saunders, EJ, Page, EC, Sawyer, EJ, Edwards, SM, Dearnaley, DP, Horwich, A, Huddart, RA, Khoo, VS, Parker, CC, Van As, N, Woodhouse, CJ, Thompson, A, Christmas, T, Ogden, C, Cooper, CS, Southey, MC, Lophatananon, A, Liu, JF, Kolonel, LN, Le Marchand, L, Wahlfors, T, Tammela, TL, Auvinen, A, Lewis, SJ, Cox, A, Fitzgerald, LM, Koopmeiners, JS, Karyadi, DM, Kwon, EM, Stern, MC, Corral, R, Joshi, AD, Shahabi, A, McDonnell, SK, Sellers, TA, Pow-Sang, J, Chambers, S, Aitken, J, Gardiner, RA, Batra, J, Kedda, MA, Lose, F, Polanowski, A, Patterson, B, Serth, J, Meyer, A, Luedeke, M, Stefflova, K, Ray, AM, Lange, EM, Farnham, J, Khan, H, Slavov, C, Mitkova, A, Cao, G & Easton, DF 2009, 'Identification of seven new prostate cancer susceptibility loci through a genome-wide association study', Nature Genetics, vol. 41, no. 10, pp. 1116-1121. https://doi.org/10.1038/ng.450

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title = "Identification of seven new prostate cancer susceptibility loci through a genome-wide association study",

abstract = "Prostate cancer (PrCa) is the most frequently diagnosed cancer in males in developed countries. To identify common PrCa susceptibility alleles, we previously conducted a genome-wide association study in which 541,129 SNPs were genotyped in 1,854 PrCa cases with clinically detected disease and in 1,894 controls. We have now extended the study to evaluate promising associations in a second stage in which we genotyped 43,671 SNPs in 3,650 PrCa cases and 3,940 controls and in a third stage involving an additional 16,229 cases and 14,821 controls from 21 studies. In addition to replicating previous associations, we identified seven new prostate cancer susceptibility loci on chromosomes 2, 4, 8, 11 and 22 (with P = 1.6 × 10 8 to P = 2.7 × 10 33).",

author = "Eeles, {Rosalind A.} and Zsofia Kote-Jarai and {Al Olama}, {Ali Amin} and Giles, {Graham G.} and Michelle Guy and Gianluca Severi and Kenneth Muir and Hopper, {John L.} and Henderson, {Brian E.} and Haiman, {Christopher A.} and Johanna Schleutker and Hamdy, {Freddie C.} and Neal, {David E.} and Donovan, {Jenny L.} and Stanford, {Janet L.} and Ostrander, {Elaine A.} and Ingles, {Sue A.} and John, {Esther M.} and Thibodeau, {Stephen N.} and Daniel Schaid and Park, {Jong Y.} and Amanda Spurdle and Judith Clements and Dickinson, {Joanne L.} and Christiane Maier and Walther Vogel and Thilo D{\"o}rk and Rebbeck, {Timothy R.} and Cooney, {Kathleen A.} and Lisa Cannon-Albright and Chappuis, {Pierre O.} and Pierre Hutter and Maurice Zeegers and Radka Kaneva and Zhang, {Hong Wei} and Lu, {Yong Jie} and Foulkes, {William D.} and English, {Dallas R.} and Leongamornlert, {Daniel A.} and Malgorzata Tymrakiewicz and Jonathan Morrison and Ardern-Jones, {Audrey T.} and Hall, {Amanda L.} and O'Brien, {Lynne T.} and Wilkinson, {Rosemary A.} and Saunders, {Edward J.} and Page, {Elizabeth C.} and Sawyer, {Emma J.} and Edwards, {Stephen M.} and Dearnaley, {David P.} and Alan Horwich and Huddart, {Robert A.} and Khoo, {Vincent S.} and Parker, {Christopher C.} and {Van As}, Nicholas and Woodhouse, {Christopher J.} and Alan Thompson and Tim Christmas and Chris Ogden and Cooper, {Colin S.} and Southey, {Melissa C.} and Artitaya Lophatananon and Liu, {Jo Fen} and Kolonel, {Laurence N.} and {Le Marchand}, Loic and Tiina Wahlfors and Tammela, {Teuvo L.} and Anssi Auvinen and Lewis, {Sarah J.} and Angela Cox and Fitzgerald, {Liesel M.} and Koopmeiners, {Joseph S.} and Karyadi, {Danielle M.} and Kwon, {Erika M.} and Stern, {Mariana C.} and Roman Corral and Joshi, {Amit D.} and Ahva Shahabi and McDonnell, {Shannon K.} and Sellers, {Thomas A.} and Julio Pow-Sang and Suzanne Chambers and Joanne Aitken and Gardiner, {R. A.} and Jyotsna Batra and Kedda, {Mary Anne} and Felicity Lose and Andrea Polanowski and Briony Patterson and J{\"u}rgen Serth and Andreas Meyer and Manuel Luedeke and Klara Stefflova and Ray, {Anna M.} and Lange, {Ethan M.} and Jim Farnham and Humera Khan and Chavdar Slavov and Atanaska Mitkova and Guangwen Cao and Easton, {Douglas F.}",

year = "2009",

month = oct,

doi = "10.1038/ng.450",

language = "English (US)",

volume = "41",

pages = "1116--1121",

journal = "Nature Genetics",

issn = "1061-4036",

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TY - JOUR

T1 - Identification of seven new prostate cancer susceptibility loci through a genome-wide association study

AU - Eeles, Rosalind A.

AU - Kote-Jarai, Zsofia

AU - Al Olama, Ali Amin

AU - Giles, Graham G.

AU - Guy, Michelle

AU - Severi, Gianluca

AU - Muir, Kenneth

AU - Hopper, John L.

AU - Henderson, Brian E.

AU - Haiman, Christopher A.

AU - Schleutker, Johanna

AU - Hamdy, Freddie C.

AU - Neal, David E.

AU - Donovan, Jenny L.

AU - Stanford, Janet L.

AU - Ostrander, Elaine A.

AU - Ingles, Sue A.

AU - John, Esther M.

AU - Thibodeau, Stephen N.

AU - Schaid, Daniel

AU - Park, Jong Y.

AU - Spurdle, Amanda

AU - Clements, Judith

AU - Dickinson, Joanne L.

AU - Maier, Christiane

AU - Vogel, Walther

AU - Dörk, Thilo

AU - Rebbeck, Timothy R.

AU - Cooney, Kathleen A.

AU - Cannon-Albright, Lisa

AU - Chappuis, Pierre O.

AU - Hutter, Pierre

AU - Zeegers, Maurice

AU - Kaneva, Radka

AU - Zhang, Hong Wei

AU - Lu, Yong Jie

AU - Foulkes, William D.

AU - English, Dallas R.

AU - Leongamornlert, Daniel A.

AU - Tymrakiewicz, Malgorzata

AU - Morrison, Jonathan

AU - Ardern-Jones, Audrey T.

AU - Hall, Amanda L.

AU - O'Brien, Lynne T.

AU - Wilkinson, Rosemary A.

AU - Saunders, Edward J.

AU - Page, Elizabeth C.

AU - Sawyer, Emma J.

AU - Edwards, Stephen M.

AU - Dearnaley, David P.

AU - Horwich, Alan

AU - Huddart, Robert A.

AU - Khoo, Vincent S.

AU - Parker, Christopher C.

AU - Van As, Nicholas

AU - Woodhouse, Christopher J.

AU - Thompson, Alan

AU - Christmas, Tim

AU - Ogden, Chris

AU - Cooper, Colin S.

AU - Southey, Melissa C.

AU - Lophatananon, Artitaya

AU - Liu, Jo Fen

AU - Kolonel, Laurence N.

AU - Le Marchand, Loic

AU - Wahlfors, Tiina

AU - Tammela, Teuvo L.

AU - Auvinen, Anssi

AU - Lewis, Sarah J.

AU - Cox, Angela

AU - Fitzgerald, Liesel M.

AU - Koopmeiners, Joseph S.

AU - Karyadi, Danielle M.

AU - Kwon, Erika M.

AU - Stern, Mariana C.

AU - Corral, Roman

AU - Joshi, Amit D.

AU - Shahabi, Ahva

AU - McDonnell, Shannon K.

AU - Sellers, Thomas A.

AU - Pow-Sang, Julio

AU - Chambers, Suzanne

AU - Aitken, Joanne

AU - Gardiner, R. A.

AU - Batra, Jyotsna

AU - Kedda, Mary Anne

AU - Lose, Felicity

AU - Polanowski, Andrea

AU - Patterson, Briony

AU - Serth, Jürgen

AU - Meyer, Andreas

AU - Luedeke, Manuel

AU - Stefflova, Klara

AU - Ray, Anna M.

AU - Lange, Ethan M.

AU - Farnham, Jim

AU - Khan, Humera

AU - Slavov, Chavdar

AU - Mitkova, Atanaska

AU - Cao, Guangwen

AU - Easton, Douglas F.

PY - 2009/10

Y1 - 2009/10

N2 - Prostate cancer (PrCa) is the most frequently diagnosed cancer in males in developed countries. To identify common PrCa susceptibility alleles, we previously conducted a genome-wide association study in which 541,129 SNPs were genotyped in 1,854 PrCa cases with clinically detected disease and in 1,894 controls. We have now extended the study to evaluate promising associations in a second stage in which we genotyped 43,671 SNPs in 3,650 PrCa cases and 3,940 controls and in a third stage involving an additional 16,229 cases and 14,821 controls from 21 studies. In addition to replicating previous associations, we identified seven new prostate cancer susceptibility loci on chromosomes 2, 4, 8, 11 and 22 (with P = 1.6 × 10 8 to P = 2.7 × 10 33).

AB - Prostate cancer (PrCa) is the most frequently diagnosed cancer in males in developed countries. To identify common PrCa susceptibility alleles, we previously conducted a genome-wide association study in which 541,129 SNPs were genotyped in 1,854 PrCa cases with clinically detected disease and in 1,894 controls. We have now extended the study to evaluate promising associations in a second stage in which we genotyped 43,671 SNPs in 3,650 PrCa cases and 3,940 controls and in a third stage involving an additional 16,229 cases and 14,821 controls from 21 studies. In addition to replicating previous associations, we identified seven new prostate cancer susceptibility loci on chromosomes 2, 4, 8, 11 and 22 (with P = 1.6 × 10 8 to P = 2.7 × 10 33).

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U2 - 10.1038/ng.450

DO - 10.1038/ng.450

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C2 - 19767753

AN - SCOPUS:70349545839

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VL - 41

SP - 1116

EP - 1121

JO - Nature Genetics

JF - Nature Genetics

IS - 10

ER -

Identification of seven new prostate cancer susceptibility loci through a genome-wide association study

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