Identification of seven new prostate cancer susceptibility loci through a genome-wide association study

Rosalind A. Eeles, Zsofia Kote-Jarai, Ali Amin Al Olama, Graham G. Giles, Michelle Guy, Gianluca Severi, Kenneth Muir, John L. Hopper, Brian E. Henderson, Christopher A. Haiman, Johanna Schleutker, Freddie C. Hamdy, David E. Neal, Jenny L. Donovan, Janet L. Stanford, Elaine A. Ostrander, Sue A. Ingles, Esther M. John, Stephen N. Thibodeau, Daniel SchaidJong Y. Park, Amanda Spurdle, Judith Clements, Joanne L. Dickinson, Christiane Maier, Walther Vogel, Thilo Dörk, Timothy R. Rebbeck, Kathleen A. Cooney, Lisa Cannon-Albright, Pierre O. Chappuis, Pierre Hutter, Maurice Zeegers, Radka Kaneva, Hong Wei Zhang, Yong Jie Lu, William D. Foulkes, Dallas R. English, Daniel A. Leongamornlert, Malgorzata Tymrakiewicz, Jonathan Morrison, Audrey T. Ardern-Jones, Amanda L. Hall, Lynne T. O'Brien, Rosemary A. Wilkinson, Edward J. Saunders, Elizabeth C. Page, Emma J. Sawyer, Stephen M. Edwards, David P. Dearnaley, Alan Horwich, Robert A. Huddart, Vincent S. Khoo, Christopher C. Parker, Nicholas Van As, Christopher J. Woodhouse, Alan Thompson, Tim Christmas, Chris Ogden, Colin S. Cooper, Melissa C. Southey, Artitaya Lophatananon, Jo Fen Liu, Laurence N. Kolonel, Loic Le Marchand, Tiina Wahlfors, Teuvo L. Tammela, Anssi Auvinen, Sarah J. Lewis, Angela Cox, Liesel M. Fitzgerald, Joseph S. Koopmeiners, Danielle M. Karyadi, Erika M. Kwon, Mariana C. Stern, Roman Corral, Amit D. Joshi, Ahva Shahabi, Shannon K. McDonnell, Thomas A. Sellers, Julio Pow-Sang, Suzanne Chambers, Joanne Aitken, R. A. Gardiner, Jyotsna Batra, Mary Anne Kedda, Felicity Lose, Andrea Polanowski, Briony Patterson, Jürgen Serth, Andreas Meyer, Manuel Luedeke, Klara Stefflova, Anna M. Ray, Ethan M. Lange, Jim Farnham, Humera Khan, Chavdar Slavov, Atanaska Mitkova, Guangwen Cao, Douglas F. Easton

Research output: Contribution to journalArticle

332 Scopus citations

Abstract

Prostate cancer (PrCa) is the most frequently diagnosed cancer in males in developed countries. To identify common PrCa susceptibility alleles, we previously conducted a genome-wide association study in which 541,129 SNPs were genotyped in 1,854 PrCa cases with clinically detected disease and in 1,894 controls. We have now extended the study to evaluate promising associations in a second stage in which we genotyped 43,671 SNPs in 3,650 PrCa cases and 3,940 controls and in a third stage involving an additional 16,229 cases and 14,821 controls from 21 studies. In addition to replicating previous associations, we identified seven new prostate cancer susceptibility loci on chromosomes 2, 4, 8, 11 and 22 (with P = 1.6 × 10 8 to P = 2.7 × 10 33).

Original languageEnglish (US)
Pages (from-to)1116-1121
Number of pages6
JournalNature Genetics
Volume41
Issue number10
DOIs
StatePublished - Oct 2009

ASJC Scopus subject areas

  • Genetics

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    Eeles, R. A., Kote-Jarai, Z., Al Olama, A. A., Giles, G. G., Guy, M., Severi, G., Muir, K., Hopper, J. L., Henderson, B. E., Haiman, C. A., Schleutker, J., Hamdy, F. C., Neal, D. E., Donovan, J. L., Stanford, J. L., Ostrander, E. A., Ingles, S. A., John, E. M., Thibodeau, S. N., ... Easton, D. F. (2009). Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Nature Genetics, 41(10), 1116-1121. https://doi.org/10.1038/ng.450