Identification of prognostic biomarkers for prostate cancer

Farhad Kosari, Jan Marie A. Munz, C. Dilara Savci-Heijink, Craig Spiro, Eric W. Klee, Dagmar Marie Kube, Lori Tillmans, Jeff Slezak, R. Jeffrey Karnes, John C. Cheville, George Vasmatzis

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

Purpose: This paper describes a process for the identification of genes that can report on the aggressiveness of prostate tumors and thereby add to the information provided by current pathologic analysis. Materials and Methods: Expression profiling data from over 100 laser capture microdissection derived samples from nonneoplastic epithelium; Gleason patterns 3, 4, and 5 and node metastasis prostate cancer were used to identify genes at abnormally high levels in only some tumors. These variably overexpressed genes were stratified by their association with aggressive phenotypes and were subsequently filtered to exclude genes with redundant expression patterns. Selected genes were validated in a case-control study in which cases (systemic progression within 5 years) and controls (no systemic progression at 7 years of follow-up) were matched for all clinical and pathologic criteria from time of prostatectomy (n = 175). Both cases and controls, therefore, could have nodal invasion or seminal vesicle involvement at the time of initial treatment. Results: A number of candidate variably overexpressed genes selected for their association with aggressive prostate cancer phenotype were evaluated in the case control study. The most prominent candidates were SSTR1 and genes related to proliferation, including TOP2A. Conclusions: The process described here identified genes that add information not available from current clinical measures and can improve the prognosis of prostate cancer.

Original languageEnglish (US)
Pages (from-to)1734-1743
Number of pages10
JournalClinical Cancer Research
Volume14
Issue number6
DOIs
StatePublished - Mar 15 2008

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Kosari, F., Munz, J. M. A., Savci-Heijink, C. D., Spiro, C., Klee, E. W., Kube, D. M., Tillmans, L., Slezak, J., Karnes, R. J., Cheville, J. C., & Vasmatzis, G. (2008). Identification of prognostic biomarkers for prostate cancer. Clinical Cancer Research, 14(6), 1734-1743. https://doi.org/10.1158/1078-0432.CCR-07-1494