Restricted anti-la antisera were produced by immunizing the following F1 mice with A.TL (Ik) tissues: (A.TH X B10)F1; (A.TH X 129)F1; (A.TH X C3H.Q)F1; (A.TH X B10.D2)F1, (A.TH X B10.M)F1 Analyses of these antisera suggested that specificity la.3 (Lna.3) should be subdivided into three specificities, Ia.l, la.3, and la.7, associated with the Ib, Id and If regions, respectively. Immunization of (A.TL X B10.M)F1 and (A.TL X A.TB)F1 with A.TH tissue produced anti-la.4 antibodies which were specific for Is strains. These suggested that a single specificity, la.5, is shared by the Is and the If, Ip, and Iq regions. The current view of the la antigenic makeup of various inbred and recombinant H-2 haplotypes and postulated I region map positions of their determinants are summarized.
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