I region associated antigen system (Ia) of the mouse H-2 gene complex. Further definition of Ia specificities with restricted anti Ia antisera

C. S. David, D. C. Shreffler

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24 Citations (Scopus)

Abstract

Restricted anti Ia antisera were produced by immunizing the following F1 mice with A.TL (I(k)) tissue: (A.TH x B10)F1, (A.TH x 129)F1, (A.TH x C3H.Q)F1, (A.TH x B10.D2)F1, (A.TH x B10.M)F1. Analyses of these antisera suggested that specificity Ia.3 (Lna.3) should be subdivided into 3 specificities, Ia.1, Ia.3, and Ia.7, associated with the I(b), I(d) and I(f) regions, respectively. Immunization of (A.TL x B10.M)F1 and (A.TL x A.TB)F1 with A.TH tissue produced anti Ia.4 antibodies which were specific for I(s) strains. These suggested that a single specificity, Ia.5, is shared by the I(s), I(p), and I(q) regions. The current view of the Ia antigenic makeup of various inbred and recombinant H-2 haplotypes and postulated I region map positions of their determinants are summarized.

Original languageEnglish (US)
Pages (from-to)313-321
Number of pages9
JournalTransplantation
Volume18
Issue number4
StatePublished - 1974
Externally publishedYes

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Histocompatibility Antigens Class II
Immune Sera
Haplotypes
Genes
Immunization
Antibodies

ASJC Scopus subject areas

  • Immunology
  • Transplantation

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I region associated antigen system (Ia) of the mouse H-2 gene complex. Further definition of Ia specificities with restricted anti Ia antisera. / David, C. S.; Shreffler, D. C.

In: Transplantation, Vol. 18, No. 4, 1974, p. 313-321.

Research output: Contribution to journalArticle

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