I region-associated antigen system (Ia) of the mouse H-2 gene complex: Further definition of la specificities with restricted anti-ia antisera1

Chella S. David, Donald C. Shreffler

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Restricted anti-la antisera were produced by immunizing the following F1 mice with A.TL (Ik) tissues: (A.TH X B10)F1; (A.TH X 129)F1; (A.TH X C3H.Q)F1; (A.TH X B10.D2)F1, (A.TH X B10.M)F1 Analyses of these antisera suggested that specificity la.3 (Lna.3) should be subdivided into three specificities, Ia.l, la.3, and la.7, associated with the Ib, Id and If regions, respectively. Immunization of (A.TL X B10.M)F1 and (A.TL X A.TB)F1 with A.TH tissue produced anti-la.4 antibodies which were specific for Is strains. These suggested that a single specificity, la.5, is shared by the Is and the If, Ip, and Iq regions. The current view of the la antigenic makeup of various inbred and recombinant H-2 haplotypes and postulated I region map positions of their determinants are summarized.

Original languageEnglish (US)
Pages (from-to)313-321
Number of pages9
JournalTransplantation
Volume18
Issue number4
DOIs
StatePublished - Jan 1 1974

ASJC Scopus subject areas

  • Transplantation

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