I-E expression and susceptibility to parasite infection

Donald L. Wassom, Christopher J. Krco, Chella S. David

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

In most inbred strains of mice, antigen-presenting cells express I-A and I-E antigens (class II major histocompatibility complex antigens), and these antigens are involved in antigen-recognition by T cells. In some strains I-E products are not expressed or aberrantly expressed, yet these mice seem to be immunologically normal. In this article, Don Wassom and his colleagues discuss reports that antigen presented in the context of I-E produces a response which suppresses I-A restricted T-cell proliferation, in relation to their own findings that mice which do express I-E molecules are more susceptible to certain nematode infections than mice which do not express I-E.

Original languageEnglish (US)
Pages (from-to)39-43
Number of pages5
JournalTrends in Immunology
Volume8
Issue number2
StatePublished - 1987

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Parasitic Diseases
Antigens
Nematode Infections
T-Lymphocytes
Inbred Strains Mice
Histocompatibility Antigens Class II
Antigen-Presenting Cells
Major Histocompatibility Complex
Cell Proliferation

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Wassom, D. L., Krco, C. J., & David, C. S. (1987). I-E expression and susceptibility to parasite infection. Trends in Immunology, 8(2), 39-43.

I-E expression and susceptibility to parasite infection. / Wassom, Donald L.; Krco, Christopher J.; David, Chella S.

In: Trends in Immunology, Vol. 8, No. 2, 1987, p. 39-43.

Research output: Contribution to journalArticle

Wassom, DL, Krco, CJ & David, CS 1987, 'I-E expression and susceptibility to parasite infection', Trends in Immunology, vol. 8, no. 2, pp. 39-43.
Wassom DL, Krco CJ, David CS. I-E expression and susceptibility to parasite infection. Trends in Immunology. 1987;8(2):39-43.
Wassom, Donald L. ; Krco, Christopher J. ; David, Chella S. / I-E expression and susceptibility to parasite infection. In: Trends in Immunology. 1987 ; Vol. 8, No. 2. pp. 39-43.
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