TY - JOUR
T1 - I-E expression and susceptibility to parasite infection
AU - Wassom, Donald L.
AU - Krco, Christopher J.
AU - David, Chella S.
PY - 1987
Y1 - 1987
N2 - In most inbred strains of mice, antigen-presenting cells express I-A and I-E antigens (class II major histocompatibility complex antigens), and these antigens are involved in antigen-recognition by T cells. In some strains I-E products are not expressed or aberrantly expressed, yet these mice seem to be immunologically normal. In this article, Don Wassom and his colleagues discuss reports that antigen presented in the context of I-E produces a response which suppresses I-A restricted T-cell proliferation, in relation to their own findings that mice which do express I-E molecules are more susceptible to certain nematode infections than mice which do not express I-E.
AB - In most inbred strains of mice, antigen-presenting cells express I-A and I-E antigens (class II major histocompatibility complex antigens), and these antigens are involved in antigen-recognition by T cells. In some strains I-E products are not expressed or aberrantly expressed, yet these mice seem to be immunologically normal. In this article, Don Wassom and his colleagues discuss reports that antigen presented in the context of I-E produces a response which suppresses I-A restricted T-cell proliferation, in relation to their own findings that mice which do express I-E molecules are more susceptible to certain nematode infections than mice which do not express I-E.
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M3 - Article
AN - SCOPUS:45949128459
SN - 1471-4906
VL - 8
SP - 39
EP - 43
JO - Trends in Immunology
JF - Trends in Immunology
IS - 2
ER -