Hypertrophic obstructive cardiomyopathy

What, when, why, for whom?

Carlos A. Mestres, Thomas Bartel, Antonio Sorgente, Silvana Müller, Christiane Gruner, Joseph Dearani, Eduard Quintana

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Hypertrophic cardiomyopathy is the most common genetic cardiovascular disorder and is associated with symptoms of heart failure and increased risk of sudden cardiac death. The most common condition is obstruction of the left ventricular outflow tract. Surgical septal myectomy and alcohol septal ablation are the 2 accepted modes of septal reduction therapy and are indicated when there are advanced symptoms and a peak left ventricular outflow gradient ≥ 50 mmHg. Advantages of alcohol septal ablation are limited groin approach, reduction of obstruction of the left ventricular outflow tract and functional improvement, but there are higher chances for intracardiac device implantation and residual obstruction. Septal myectomy offers very low mortality, absolute and immediate resolution of obstruction of the left ventricular outflow tract and survival comparative to a matched general population with almost negligible residual obstruction. It is recommended that patients with obstructive hypertrophic cardiomyopathy should be treated at experienced centres.

Original languageEnglish (US)
Pages (from-to)700-707
Number of pages8
JournalEuropean Journal of Cardio-thoracic Surgery
Volume53
Issue number4
DOIs
StatePublished - Apr 1 2018

Fingerprint

Ventricular Outflow Obstruction
Hypertrophic Cardiomyopathy
Alcohols
Inborn Genetic Diseases
Groin
Sudden Cardiac Death
Heart Failure
Equipment and Supplies
Survival
Mortality
Population
Therapeutics

Keywords

  • Alcohol septal ablation
  • Obstructive hypertrophic cardiomyopathy
  • Septal myectomy
  • Septal reduction therapy

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Mestres, C. A., Bartel, T., Sorgente, A., Müller, S., Gruner, C., Dearani, J., & Quintana, E. (2018). Hypertrophic obstructive cardiomyopathy: What, when, why, for whom? European Journal of Cardio-thoracic Surgery, 53(4), 700-707. https://doi.org/10.1093/ejcts/ezy020

Hypertrophic obstructive cardiomyopathy : What, when, why, for whom? / Mestres, Carlos A.; Bartel, Thomas; Sorgente, Antonio; Müller, Silvana; Gruner, Christiane; Dearani, Joseph; Quintana, Eduard.

In: European Journal of Cardio-thoracic Surgery, Vol. 53, No. 4, 01.04.2018, p. 700-707.

Research output: Contribution to journalArticle

Mestres, CA, Bartel, T, Sorgente, A, Müller, S, Gruner, C, Dearani, J & Quintana, E 2018, 'Hypertrophic obstructive cardiomyopathy: What, when, why, for whom?', European Journal of Cardio-thoracic Surgery, vol. 53, no. 4, pp. 700-707. https://doi.org/10.1093/ejcts/ezy020
Mestres CA, Bartel T, Sorgente A, Müller S, Gruner C, Dearani J et al. Hypertrophic obstructive cardiomyopathy: What, when, why, for whom? European Journal of Cardio-thoracic Surgery. 2018 Apr 1;53(4):700-707. https://doi.org/10.1093/ejcts/ezy020
Mestres, Carlos A. ; Bartel, Thomas ; Sorgente, Antonio ; Müller, Silvana ; Gruner, Christiane ; Dearani, Joseph ; Quintana, Eduard. / Hypertrophic obstructive cardiomyopathy : What, when, why, for whom?. In: European Journal of Cardio-thoracic Surgery. 2018 ; Vol. 53, No. 4. pp. 700-707.
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