Hypertension in pregnancy is a risk factor for peripheral arterial disease decades after pregnancy

Tracey L. Weissgerber, Stephen T. Turner, Kent R. Bailey, Thomas H. Mosley, Sharon L.R. Kardia, Heather J. Wiste, Virginia M. Miller, Iftikhar J. Kullo, Vesna D. Garovic

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Background: An ankle-brachial index (ABI) (the ratio of ankle to brachial artery systolic blood pressure) value ≤0.9 identifies patients with peripheral arterial disease (PAD) and elevated cardiovascular event risk. This study examined whether women with a history of hypertension in pregnancy are more likely to have an ABI ≤0.9 decades after pregnancy. Methods and results: ABI was measured in nulliparous women (. n=144), and women with a history of normotensive (. n=1272) or hypertensive (. n=281) pregnancies who participated in the Genetic Epidemiology Network of Arteriopathy (GENOA) study [non-Hispanic white (39%) and black (61%) women, 60 (mean)±10 (SD) years of age]. Relationships between PAD and pregnancy history were examined by logistic regression. Compared to women with a history of normotensive pregnancy, women with a history of hypertensive pregnancy had greater odds of PAD (1.61 (odds ratio); 1.04-2.49 (95% confidence interval), p=0.03, adjusted for age, race, height and heart rate). Additional adjustment for ever smoking, hypertension, diabetes, dyslipidemia, a family history of hypertension or coronary heart disease, body mass index and education did not attenuate this relationship (1.63; 1.02-2.62, p=0.04). PAD risk did not differ between women with a history of normotensive pregnancy and nulliparous women (1.06; 0.52-2.14, p=0.87). Conclusions: Hypertension in pregnancy is an independent risk factor for PAD decades after pregnancy after adjusting for race, age, height, heart rate, ever smoking, hypertension, diabetes, dyslipidemia, a family history of hypertension or coronary heart disease, body mass index and education.

Original languageEnglish (US)
Pages (from-to)212-216
Number of pages5
JournalAtherosclerosis
Volume229
Issue number1
DOIs
StatePublished - Jul 1 2013

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Keywords

  • Ankle-brachial index
  • Hypertension in pregnancy
  • Peripheral vascular disease

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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