Abstract
Background: An ankle-brachial index (ABI) (the ratio of ankle to brachial artery systolic blood pressure) value ≤0.9 identifies patients with peripheral arterial disease (PAD) and elevated cardiovascular event risk. This study examined whether women with a history of hypertension in pregnancy are more likely to have an ABI ≤0.9 decades after pregnancy. Methods and results: ABI was measured in nulliparous women (. n=144), and women with a history of normotensive (. n=1272) or hypertensive (. n=281) pregnancies who participated in the Genetic Epidemiology Network of Arteriopathy (GENOA) study [non-Hispanic white (39%) and black (61%) women, 60 (mean)±10 (SD) years of age]. Relationships between PAD and pregnancy history were examined by logistic regression. Compared to women with a history of normotensive pregnancy, women with a history of hypertensive pregnancy had greater odds of PAD (1.61 (odds ratio); 1.04-2.49 (95% confidence interval), p=0.03, adjusted for age, race, height and heart rate). Additional adjustment for ever smoking, hypertension, diabetes, dyslipidemia, a family history of hypertension or coronary heart disease, body mass index and education did not attenuate this relationship (1.63; 1.02-2.62, p=0.04). PAD risk did not differ between women with a history of normotensive pregnancy and nulliparous women (1.06; 0.52-2.14, p=0.87). Conclusions: Hypertension in pregnancy is an independent risk factor for PAD decades after pregnancy after adjusting for race, age, height, heart rate, ever smoking, hypertension, diabetes, dyslipidemia, a family history of hypertension or coronary heart disease, body mass index and education.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 212-216 |
| Number of pages | 5 |
| Journal | Atherosclerosis |
| Volume | 229 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jul 2013 |
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Keywords
- Ankle-brachial index
- Hypertension in pregnancy
- Peripheral vascular disease
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Hypertension in pregnancy is a risk factor for peripheral arterial disease decades after pregnancy. / Weissgerber, Tracey L.; Turner, Stephen T; Bailey, Kent R; Mosley, Thomas H.; Kardia, Sharon L R; Wiste, Heather J.; Miller, Virginia M; Kullo, Iftikhar Jan; Garovic, Vesna D.
In: Atherosclerosis, Vol. 229, No. 1, 07.2013, p. 212-216.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hypertension in pregnancy is a risk factor for peripheral arterial disease decades after pregnancy
AU - Weissgerber, Tracey L.
AU - Turner, Stephen T
AU - Bailey, Kent R
AU - Mosley, Thomas H.
AU - Kardia, Sharon L R
AU - Wiste, Heather J.
AU - Miller, Virginia M
AU - Kullo, Iftikhar Jan
AU - Garovic, Vesna D
PY - 2013/7
Y1 - 2013/7
N2 - Background: An ankle-brachial index (ABI) (the ratio of ankle to brachial artery systolic blood pressure) value ≤0.9 identifies patients with peripheral arterial disease (PAD) and elevated cardiovascular event risk. This study examined whether women with a history of hypertension in pregnancy are more likely to have an ABI ≤0.9 decades after pregnancy. Methods and results: ABI was measured in nulliparous women (. n=144), and women with a history of normotensive (. n=1272) or hypertensive (. n=281) pregnancies who participated in the Genetic Epidemiology Network of Arteriopathy (GENOA) study [non-Hispanic white (39%) and black (61%) women, 60 (mean)±10 (SD) years of age]. Relationships between PAD and pregnancy history were examined by logistic regression. Compared to women with a history of normotensive pregnancy, women with a history of hypertensive pregnancy had greater odds of PAD (1.61 (odds ratio); 1.04-2.49 (95% confidence interval), p=0.03, adjusted for age, race, height and heart rate). Additional adjustment for ever smoking, hypertension, diabetes, dyslipidemia, a family history of hypertension or coronary heart disease, body mass index and education did not attenuate this relationship (1.63; 1.02-2.62, p=0.04). PAD risk did not differ between women with a history of normotensive pregnancy and nulliparous women (1.06; 0.52-2.14, p=0.87). Conclusions: Hypertension in pregnancy is an independent risk factor for PAD decades after pregnancy after adjusting for race, age, height, heart rate, ever smoking, hypertension, diabetes, dyslipidemia, a family history of hypertension or coronary heart disease, body mass index and education.
AB - Background: An ankle-brachial index (ABI) (the ratio of ankle to brachial artery systolic blood pressure) value ≤0.9 identifies patients with peripheral arterial disease (PAD) and elevated cardiovascular event risk. This study examined whether women with a history of hypertension in pregnancy are more likely to have an ABI ≤0.9 decades after pregnancy. Methods and results: ABI was measured in nulliparous women (. n=144), and women with a history of normotensive (. n=1272) or hypertensive (. n=281) pregnancies who participated in the Genetic Epidemiology Network of Arteriopathy (GENOA) study [non-Hispanic white (39%) and black (61%) women, 60 (mean)±10 (SD) years of age]. Relationships between PAD and pregnancy history were examined by logistic regression. Compared to women with a history of normotensive pregnancy, women with a history of hypertensive pregnancy had greater odds of PAD (1.61 (odds ratio); 1.04-2.49 (95% confidence interval), p=0.03, adjusted for age, race, height and heart rate). Additional adjustment for ever smoking, hypertension, diabetes, dyslipidemia, a family history of hypertension or coronary heart disease, body mass index and education did not attenuate this relationship (1.63; 1.02-2.62, p=0.04). PAD risk did not differ between women with a history of normotensive pregnancy and nulliparous women (1.06; 0.52-2.14, p=0.87). Conclusions: Hypertension in pregnancy is an independent risk factor for PAD decades after pregnancy after adjusting for race, age, height, heart rate, ever smoking, hypertension, diabetes, dyslipidemia, a family history of hypertension or coronary heart disease, body mass index and education.
KW - Ankle-brachial index
KW - Hypertension in pregnancy
KW - Peripheral vascular disease
UR - http://www.scopus.com/inward/record.url?scp=84879410605&partnerID=8YFLogxK
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U2 - 10.1016/j.atherosclerosis.2013.04.012
DO - 10.1016/j.atherosclerosis.2013.04.012
M3 - Article
VL - 229
SP - 212
EP - 216
JO - Atherosclerosis
JF - Atherosclerosis
SN - 0021-9150
IS - 1
ER -