TY - JOUR
T1 - Hypertension in pregnancy is a risk factor for peripheral arterial disease decades after pregnancy
AU - Weissgerber, Tracey L.
AU - Turner, Stephen T.
AU - Bailey, Kent R.
AU - Mosley, Thomas H.
AU - Kardia, Sharon L.R.
AU - Wiste, Heather J.
AU - Miller, Virginia M.
AU - Kullo, Iftikhar J.
AU - Garovic, Vesna D.
N1 - Funding Information:
Grant Support: This work was supported by grants from the National Heart, Lung, and Blood Institute and NIH ( U01HL054481 , U01HL054471 , U01HL054512 , and U01HL054498 ). The project described was supported by Award Number K08HD051714 (V.D. Garovic) from the Eunice Kennedy Shriver National Institute of Child Health & Human Development and by Award Number P-50 AG44170 from the National Institute on Aging , and the Society for Womens Health Research (SWHR) ISIS Network award (V.D. Garovic, V.M. Miller). Tracey Weissgerber was supported by the Office of Women's Health Research (Building Interdisciplinary Careers in Women's Health award K12HD065987). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. The writing of the manuscript and the decision to submit it for publication were solely the authors' responsibilities.
PY - 2013/7
Y1 - 2013/7
N2 - Background: An ankle-brachial index (ABI) (the ratio of ankle to brachial artery systolic blood pressure) value ≤0.9 identifies patients with peripheral arterial disease (PAD) and elevated cardiovascular event risk. This study examined whether women with a history of hypertension in pregnancy are more likely to have an ABI ≤0.9 decades after pregnancy. Methods and results: ABI was measured in nulliparous women (. n=144), and women with a history of normotensive (. n=1272) or hypertensive (. n=281) pregnancies who participated in the Genetic Epidemiology Network of Arteriopathy (GENOA) study [non-Hispanic white (39%) and black (61%) women, 60 (mean)±10 (SD) years of age]. Relationships between PAD and pregnancy history were examined by logistic regression. Compared to women with a history of normotensive pregnancy, women with a history of hypertensive pregnancy had greater odds of PAD (1.61 (odds ratio); 1.04-2.49 (95% confidence interval), p=0.03, adjusted for age, race, height and heart rate). Additional adjustment for ever smoking, hypertension, diabetes, dyslipidemia, a family history of hypertension or coronary heart disease, body mass index and education did not attenuate this relationship (1.63; 1.02-2.62, p=0.04). PAD risk did not differ between women with a history of normotensive pregnancy and nulliparous women (1.06; 0.52-2.14, p=0.87). Conclusions: Hypertension in pregnancy is an independent risk factor for PAD decades after pregnancy after adjusting for race, age, height, heart rate, ever smoking, hypertension, diabetes, dyslipidemia, a family history of hypertension or coronary heart disease, body mass index and education.
AB - Background: An ankle-brachial index (ABI) (the ratio of ankle to brachial artery systolic blood pressure) value ≤0.9 identifies patients with peripheral arterial disease (PAD) and elevated cardiovascular event risk. This study examined whether women with a history of hypertension in pregnancy are more likely to have an ABI ≤0.9 decades after pregnancy. Methods and results: ABI was measured in nulliparous women (. n=144), and women with a history of normotensive (. n=1272) or hypertensive (. n=281) pregnancies who participated in the Genetic Epidemiology Network of Arteriopathy (GENOA) study [non-Hispanic white (39%) and black (61%) women, 60 (mean)±10 (SD) years of age]. Relationships between PAD and pregnancy history were examined by logistic regression. Compared to women with a history of normotensive pregnancy, women with a history of hypertensive pregnancy had greater odds of PAD (1.61 (odds ratio); 1.04-2.49 (95% confidence interval), p=0.03, adjusted for age, race, height and heart rate). Additional adjustment for ever smoking, hypertension, diabetes, dyslipidemia, a family history of hypertension or coronary heart disease, body mass index and education did not attenuate this relationship (1.63; 1.02-2.62, p=0.04). PAD risk did not differ between women with a history of normotensive pregnancy and nulliparous women (1.06; 0.52-2.14, p=0.87). Conclusions: Hypertension in pregnancy is an independent risk factor for PAD decades after pregnancy after adjusting for race, age, height, heart rate, ever smoking, hypertension, diabetes, dyslipidemia, a family history of hypertension or coronary heart disease, body mass index and education.
KW - Ankle-brachial index
KW - Hypertension in pregnancy
KW - Peripheral vascular disease
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U2 - 10.1016/j.atherosclerosis.2013.04.012
DO - 10.1016/j.atherosclerosis.2013.04.012
M3 - Article
C2 - 23659871
AN - SCOPUS:84879410605
SN - 0021-9150
VL - 229
SP - 212
EP - 216
JO - Atherosclerosis
JF - Atherosclerosis
IS - 1
ER -