TY - JOUR
T1 - Hypertension and Left Ventricular Diastolic Function
AU - SHEPHERD, ROGER F.J.
AU - ZACHARIAH, PRINCE K.
AU - SHUB, CLARENCE
PY - 1989
Y1 - 1989
N2 - In recent years, there has been increased recognition of the relative importance of abnormalities of diastolic function in patients with essential hypertension. Indeed, diastolic dysfunction may be the earliest indicator of hypertensive heart disease. In this article, the mechanisms governing normal ventricular relaxation and the factors that may cause diastolic dysfunction are reviewed. Noninvasive clinical methods, particularly Doppler echocardiography and radionuclide angiography, for determination of diastolic function are outlined, and the limited experience in the management of hypertensive patients with abnormalities of diastolic function is discussed. When congestive heart failure develops in a patient with hypertension, it is especially important to determine whether it is due primarily to systolic or to diastolic left ventricular dysfunction.
AB - In recent years, there has been increased recognition of the relative importance of abnormalities of diastolic function in patients with essential hypertension. Indeed, diastolic dysfunction may be the earliest indicator of hypertensive heart disease. In this article, the mechanisms governing normal ventricular relaxation and the factors that may cause diastolic dysfunction are reviewed. Noninvasive clinical methods, particularly Doppler echocardiography and radionuclide angiography, for determination of diastolic function are outlined, and the limited experience in the management of hypertensive patients with abnormalities of diastolic function is discussed. When congestive heart failure develops in a patient with hypertension, it is especially important to determine whether it is due primarily to systolic or to diastolic left ventricular dysfunction.
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U2 - 10.1016/S0025-6196(12)65708-5
DO - 10.1016/S0025-6196(12)65708-5
M3 - Article
C2 - 2574761
AN - SCOPUS:0024821330
SN - 0025-6196
VL - 64
SP - 1521
EP - 1532
JO - Mayo Clinic proceedings
JF - Mayo Clinic proceedings
IS - 12
ER -