Human papillomavirus vaccine (HPV) and autonomic disorders

A position statement from the American Autonomic Society

on behalf of the American Autonomic Society

Research output: Contribution to journalArticle

Abstract

Introduction: Human papillomavirus (HPV) vaccination has been anecdotally connected to development of dysautonomia, chronic fatigue, complex regional pain syndrome and postural tachycardia syndrome. Objectives: To critically evaluate a potential connection between HPV vaccination and above noted conditions. Methods: We reviewed the literature containing the biology of the virus, pathophysiology of infection, epidemiology of associated cancers, indications of HPV vaccination, safety surveillance data and published reports linking HPV vaccination to autonomic disorders. Results: At this time the American Autonomic Society finds that there are no data to support a causal relationship between HPV vaccination and CRPS, chronic fatigue, POTS or other forms of dysautonomia. Conclusions: Certain conditions are prevalent in the same patient populations that are vaccinated with the HPV vaccine (peri-pubertal males and females). This association, however, is insufficient proof of causality.

Original languageEnglish (US)
Article number102550
JournalAutonomic Neuroscience: Basic and Clinical
DOIs
StatePublished - Jan 1 2019

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Papillomavirus Vaccines
Vaccination
Primary Dysautonomias
Fatigue
Postural Orthostatic Tachycardia Syndrome
Complex Regional Pain Syndromes
Virus Diseases
Causality
Epidemiology
Vaccines
Safety
Population
Neoplasms

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Cite this

Human papillomavirus vaccine (HPV) and autonomic disorders : A position statement from the American Autonomic Society. / on behalf of the American Autonomic Society.

In: Autonomic Neuroscience: Basic and Clinical, 01.01.2019.

Research output: Contribution to journalArticle

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author = "{on behalf of the American Autonomic Society} and Alexandru Barboi and Gibbons, {Christopher H.} and Felicia Axelrod and Benarroch, {Eduardo E.} and Italo Biaggioni and Chapleau, {Mark W.} and Gisela Chelimsky and Thomas Chelimsky and Cheshire, {William P.} and Claydon, {Victoria E.} and Roy Freeman and Goldstein, {David S.} and Joyner, {Michael Joseph} and Horacio Kaufmann and Low, {Phillip Anson} and Lucy Norcliffe-Kaufmann and David Robertson and Shibao, {Cyndya A.} and Wolfgang Singer and Howard Snapper and Steven Vernino and Raj, {Satish R.}",
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