Human Papillomavirus and the Development of Different Cancers

Research output: Contribution to journalReview article

19 Scopus citations

Abstract

Human papillomaviruses (HPV) are responsible for the development of almost all cervical cancers. HPV is also found in 85% of anal cancer and in 50% of penile, vulvar, and vaginal cancers, and they are increasingly found in a subset of head and neck cancers, i.e., oropharyngeal squamous cell carcinomas (OPSCC). The model for how HPV causes cancer is derived from several decades of study on cervical cancer, and it is just presumed that this model is not only completely valid for cervical cancer but for all other HPV-driven cancers as well. Next-generation sequencing (NGS) has now provided the necessary tools to characterize genomic alterations in cancer cells and can precisely determine the physical status of HPV in those cells as well. We discuss recent discoveries from different applications of NGS in both cervical cancer and OPSCCs, including whole-genome sequencing and mate-pair NGS. We also discuss what NGS studies have revealed about the different ways that HPV can be involved in cancer formation, specifically comparing cervical cancer and OPSCC.

Original languageEnglish (US)
Pages (from-to)185-193
Number of pages9
JournalCytogenetic and Genome Research
Volume150
Issue number3-4
DOIs
StatePublished - Mar 1 2017

Keywords

  • Cervical cancer • Integration site • Next-generation sequencing • Oropharyngeal squamous cell carcinoma

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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