Human neutrophil migratory function: Modulatory effect of interactions with opsonized particles

Neil Elliot Kay, S. D. Douglas, R. D. Nelson

Research output: Contribution to journalArticle

Abstract

Human polymorphonuclear neutrophils preexposed to cytotaxin or to phagocytizable particles exhibited reduced spontaneous and chemotactic migratory responses. This influence of cytotaxin appears to be related to toxic effects of byproducts of hexose monophosphate shunt stimulation. To determine whether a phagocytic stimulus may inhibit subsequent neutrophil migratory functions by the same mechanism, we assessed spontaneous and chemotactic migratory functions of neutrophils from individuals with chronic granulomatous disease exposed to antibody-opsonized sheep erythrocytes. Our results showed that phagocytosis of such particles did not alter these migratory responses of chronic granulomatous disease neutrophils and suggest that phagocytic stimulation of normal neutrophils may modulate migratory function by some mechanism dependent upon hexose monophosphate shunt stimulation.

Original languageEnglish (US)
Pages (from-to)12-14
Number of pages3
JournalInfection and Immunity
Volume26
Issue number1
StatePublished - 1979
Externally publishedYes

Fingerprint

Neutrophils
Chronic Granulomatous Disease
Pentose Phosphate Pathway
Chemotactic Factors
Poisons
Phagocytosis
Sheep
Erythrocytes
Antibodies

ASJC Scopus subject areas

  • Immunology

Cite this

Human neutrophil migratory function : Modulatory effect of interactions with opsonized particles. / Kay, Neil Elliot; Douglas, S. D.; Nelson, R. D.

In: Infection and Immunity, Vol. 26, No. 1, 1979, p. 12-14.

Research output: Contribution to journalArticle

@article{a8d9ae34462041ae8e330e005cb4861e,
title = "Human neutrophil migratory function: Modulatory effect of interactions with opsonized particles",
abstract = "Human polymorphonuclear neutrophils preexposed to cytotaxin or to phagocytizable particles exhibited reduced spontaneous and chemotactic migratory responses. This influence of cytotaxin appears to be related to toxic effects of byproducts of hexose monophosphate shunt stimulation. To determine whether a phagocytic stimulus may inhibit subsequent neutrophil migratory functions by the same mechanism, we assessed spontaneous and chemotactic migratory functions of neutrophils from individuals with chronic granulomatous disease exposed to antibody-opsonized sheep erythrocytes. Our results showed that phagocytosis of such particles did not alter these migratory responses of chronic granulomatous disease neutrophils and suggest that phagocytic stimulation of normal neutrophils may modulate migratory function by some mechanism dependent upon hexose monophosphate shunt stimulation.",
author = "Kay, {Neil Elliot} and Douglas, {S. D.} and Nelson, {R. D.}",
year = "1979",
language = "English (US)",
volume = "26",
pages = "12--14",
journal = "Infection and Immunity",
issn = "0019-9567",
publisher = "American Society for Microbiology",
number = "1",

}

TY - JOUR

T1 - Human neutrophil migratory function

T2 - Modulatory effect of interactions with opsonized particles

AU - Kay, Neil Elliot

AU - Douglas, S. D.

AU - Nelson, R. D.

PY - 1979

Y1 - 1979

N2 - Human polymorphonuclear neutrophils preexposed to cytotaxin or to phagocytizable particles exhibited reduced spontaneous and chemotactic migratory responses. This influence of cytotaxin appears to be related to toxic effects of byproducts of hexose monophosphate shunt stimulation. To determine whether a phagocytic stimulus may inhibit subsequent neutrophil migratory functions by the same mechanism, we assessed spontaneous and chemotactic migratory functions of neutrophils from individuals with chronic granulomatous disease exposed to antibody-opsonized sheep erythrocytes. Our results showed that phagocytosis of such particles did not alter these migratory responses of chronic granulomatous disease neutrophils and suggest that phagocytic stimulation of normal neutrophils may modulate migratory function by some mechanism dependent upon hexose monophosphate shunt stimulation.

AB - Human polymorphonuclear neutrophils preexposed to cytotaxin or to phagocytizable particles exhibited reduced spontaneous and chemotactic migratory responses. This influence of cytotaxin appears to be related to toxic effects of byproducts of hexose monophosphate shunt stimulation. To determine whether a phagocytic stimulus may inhibit subsequent neutrophil migratory functions by the same mechanism, we assessed spontaneous and chemotactic migratory functions of neutrophils from individuals with chronic granulomatous disease exposed to antibody-opsonized sheep erythrocytes. Our results showed that phagocytosis of such particles did not alter these migratory responses of chronic granulomatous disease neutrophils and suggest that phagocytic stimulation of normal neutrophils may modulate migratory function by some mechanism dependent upon hexose monophosphate shunt stimulation.

UR - http://www.scopus.com/inward/record.url?scp=0018686369&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018686369&partnerID=8YFLogxK

M3 - Article

C2 - 500198

AN - SCOPUS:0018686369

VL - 26

SP - 12

EP - 14

JO - Infection and Immunity

JF - Infection and Immunity

SN - 0019-9567

IS - 1

ER -