Human leukocyte antigen polymorphisms: Variable humoral immune responses to viral vaccines

Inna G. Ovsyannikova; Neelam Dhiman; Robert M. Jacobson; Gregory A. Poland

doi:10.1586/14760584.5.1.33

Human leukocyte antigen polymorphisms: Variable humoral immune responses to viral vaccines

Inna G. Ovsyannikova, Neelam Dhiman, Robert M. Jacobson, Gregory A. Poland

Research output: Contribution to journal › Review article › peer-review

29 Scopus citations

Abstract

Antibody formation in response to antigen stimulation remains the basis for measuring an individual's response and protection for most viral vaccines. A significant proportion of the variation in individual humoral immune response to vaccination appears to be genetic. The collection of genes found on chromosome 6 forming the human leukocyte antigen system provides one of the greatest sources of genetic variation in Individuals with respect to their immunological responses. Recent research has demonstrated significant associations between vaccine response and human leukocyte antigen alleles. These associations not only explain why vaccine-induced humoral immune responses vary among individuals and between populations, but these variations may also hold the key to the development of future generations of vaccines.

Original language	English (US)
Pages (from-to)	33-43
Number of pages	11
Journal	Expert review of vaccines
Volume	5
Issue number	1
DOIs	https://doi.org/10.1586/14760584.5.1.33
State	Published - Feb 2006

Keywords

Antibody formation
Antigen processing
Antigens
Cytokines
Human leukocyte antigens
Humoral immunity
Measles
T cells
Viral vaccines

ASJC Scopus subject areas

Immunology
Molecular Medicine
Pharmacology
Drug Discovery

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10.1586/14760584.5.1.33

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title = "Human leukocyte antigen polymorphisms: Variable humoral immune responses to viral vaccines",

abstract = "Antibody formation in response to antigen stimulation remains the basis for measuring an individual's response and protection for most viral vaccines. A significant proportion of the variation in individual humoral immune response to vaccination appears to be genetic. The collection of genes found on chromosome 6 forming the human leukocyte antigen system provides one of the greatest sources of genetic variation in Individuals with respect to their immunological responses. Recent research has demonstrated significant associations between vaccine response and human leukocyte antigen alleles. These associations not only explain why vaccine-induced humoral immune responses vary among individuals and between populations, but these variations may also hold the key to the development of future generations of vaccines.",

keywords = "Antibody formation, Antigen processing, Antigens, Cytokines, Human leukocyte antigens, Humoral immunity, Measles, T cells, Viral vaccines",

author = "Ovsyannikova, {Inna G.} and Neelam Dhiman and Jacobson, {Robert M.} and Poland, {Gregory A.}",

note = "Funding Information: The authors acknowledge Carla L Tentis for editorial assistance in preparing this manuscript and Eric D Mortenson for help in preparing the figure. This work was supported in part by National Institutes of Health grants AI 53592, AI 33144, AI 48793 and the Mayo Clinic General Clinical Research Center M01 RR00585.",

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doi = "10.1586/14760584.5.1.33",

language = "English (US)",

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T2 - Variable humoral immune responses to viral vaccines

AU - Ovsyannikova, Inna G.

AU - Dhiman, Neelam

AU - Jacobson, Robert M.

AU - Poland, Gregory A.

N1 - Funding Information: The authors acknowledge Carla L Tentis for editorial assistance in preparing this manuscript and Eric D Mortenson for help in preparing the figure. This work was supported in part by National Institutes of Health grants AI 53592, AI 33144, AI 48793 and the Mayo Clinic General Clinical Research Center M01 RR00585.

PY - 2006/2

Y1 - 2006/2

N2 - Antibody formation in response to antigen stimulation remains the basis for measuring an individual's response and protection for most viral vaccines. A significant proportion of the variation in individual humoral immune response to vaccination appears to be genetic. The collection of genes found on chromosome 6 forming the human leukocyte antigen system provides one of the greatest sources of genetic variation in Individuals with respect to their immunological responses. Recent research has demonstrated significant associations between vaccine response and human leukocyte antigen alleles. These associations not only explain why vaccine-induced humoral immune responses vary among individuals and between populations, but these variations may also hold the key to the development of future generations of vaccines.

AB - Antibody formation in response to antigen stimulation remains the basis for measuring an individual's response and protection for most viral vaccines. A significant proportion of the variation in individual humoral immune response to vaccination appears to be genetic. The collection of genes found on chromosome 6 forming the human leukocyte antigen system provides one of the greatest sources of genetic variation in Individuals with respect to their immunological responses. Recent research has demonstrated significant associations between vaccine response and human leukocyte antigen alleles. These associations not only explain why vaccine-induced humoral immune responses vary among individuals and between populations, but these variations may also hold the key to the development of future generations of vaccines.

KW - Antibody formation

KW - Antigen processing

KW - Antigens

KW - Cytokines

KW - Human leukocyte antigens

KW - Humoral immunity

KW - Measles

KW - T cells

KW - Viral vaccines

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Human leukocyte antigen polymorphisms: Variable humoral immune responses to viral vaccines

Abstract

Keywords

ASJC Scopus subject areas

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