Human leukocyte antigen class I and II alleles in non-Hodgkin lymphoma etiology

Sophia S. Wang, Amr M. Abdou, Lindsay M. Morton, Rasmi Thomas, James R Cerhan, Xiaojiang Gao, Wendy Cozen, Nathaniel Rothman, Scott Davis, Richard K. Severson, Leslie Bernstein, Patricia Hartge, Mary Carrington

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Genome-wide association and candidate gene studies implicate different genetic variants within the 6p21 chromosomal region with different non-Hodgkin lymphoma (NHL) subtypes. Complementing these efforts, we conducted human leukocyte antigen (HLA) class I and class II genotyping among 610 NHL cases and 555 controls of non-Hispanic white descent from a US multicenter study. Allele-disease associations were assessed by logistic regression for NHL and its subtypes. Statistically significant associations between HLA and NHL subtypes include HLA-DRB1*0101 for follicular lymphoma (odds ratio [OR] = 2.14, P < .001), HLA-DRB1*0401 for diffuse large B-cell lymphoma (DLBCL; OR = 0.45, P = .006), and HLA-DRB1*13 and follicular lymphoma (OR = 0.48, P = .008). We further observed significant heterozygote advantage for HLA class I alleles and NHL, and particularly DLBCL (P trend = .01 for elevated risk with increasing number of homozygous alleles). Our results support a role for HLA in the etiology of NHL and its subtypes.

Original languageEnglish (US)
Pages (from-to)4820-4823
Number of pages4
JournalBlood
Volume115
Issue number23
DOIs
StatePublished - Jun 10 2010

Fingerprint

HLA Antigens
Non-Hodgkin's Lymphoma
Alleles
Follicular Lymphoma
Odds Ratio
Genes
Lymphoma, Large B-Cell, Diffuse
Genetic Association Studies
Heterozygote
Multicenter Studies
Logistics
Logistic Models
Cells
Genome

ASJC Scopus subject areas

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology

Cite this

Wang, S. S., Abdou, A. M., Morton, L. M., Thomas, R., Cerhan, J. R., Gao, X., ... Carrington, M. (2010). Human leukocyte antigen class I and II alleles in non-Hodgkin lymphoma etiology. Blood, 115(23), 4820-4823. https://doi.org/10.1182/blood-2010-01-266775

Human leukocyte antigen class I and II alleles in non-Hodgkin lymphoma etiology. / Wang, Sophia S.; Abdou, Amr M.; Morton, Lindsay M.; Thomas, Rasmi; Cerhan, James R; Gao, Xiaojiang; Cozen, Wendy; Rothman, Nathaniel; Davis, Scott; Severson, Richard K.; Bernstein, Leslie; Hartge, Patricia; Carrington, Mary.

In: Blood, Vol. 115, No. 23, 10.06.2010, p. 4820-4823.

Research output: Contribution to journalArticle

Wang, SS, Abdou, AM, Morton, LM, Thomas, R, Cerhan, JR, Gao, X, Cozen, W, Rothman, N, Davis, S, Severson, RK, Bernstein, L, Hartge, P & Carrington, M 2010, 'Human leukocyte antigen class I and II alleles in non-Hodgkin lymphoma etiology', Blood, vol. 115, no. 23, pp. 4820-4823. https://doi.org/10.1182/blood-2010-01-266775
Wang, Sophia S. ; Abdou, Amr M. ; Morton, Lindsay M. ; Thomas, Rasmi ; Cerhan, James R ; Gao, Xiaojiang ; Cozen, Wendy ; Rothman, Nathaniel ; Davis, Scott ; Severson, Richard K. ; Bernstein, Leslie ; Hartge, Patricia ; Carrington, Mary. / Human leukocyte antigen class I and II alleles in non-Hodgkin lymphoma etiology. In: Blood. 2010 ; Vol. 115, No. 23. pp. 4820-4823.
@article{cbb95c40bde94a14811a9574f35ae4f3,
title = "Human leukocyte antigen class I and II alleles in non-Hodgkin lymphoma etiology",
abstract = "Genome-wide association and candidate gene studies implicate different genetic variants within the 6p21 chromosomal region with different non-Hodgkin lymphoma (NHL) subtypes. Complementing these efforts, we conducted human leukocyte antigen (HLA) class I and class II genotyping among 610 NHL cases and 555 controls of non-Hispanic white descent from a US multicenter study. Allele-disease associations were assessed by logistic regression for NHL and its subtypes. Statistically significant associations between HLA and NHL subtypes include HLA-DRB1*0101 for follicular lymphoma (odds ratio [OR] = 2.14, P < .001), HLA-DRB1*0401 for diffuse large B-cell lymphoma (DLBCL; OR = 0.45, P = .006), and HLA-DRB1*13 and follicular lymphoma (OR = 0.48, P = .008). We further observed significant heterozygote advantage for HLA class I alleles and NHL, and particularly DLBCL (P trend = .01 for elevated risk with increasing number of homozygous alleles). Our results support a role for HLA in the etiology of NHL and its subtypes.",
author = "Wang, {Sophia S.} and Abdou, {Amr M.} and Morton, {Lindsay M.} and Rasmi Thomas and Cerhan, {James R} and Xiaojiang Gao and Wendy Cozen and Nathaniel Rothman and Scott Davis and Severson, {Richard K.} and Leslie Bernstein and Patricia Hartge and Mary Carrington",
year = "2010",
month = "6",
day = "10",
doi = "10.1182/blood-2010-01-266775",
language = "English (US)",
volume = "115",
pages = "4820--4823",
journal = "Blood",
issn = "0006-4971",
publisher = "American Society of Hematology",
number = "23",

}

TY - JOUR

T1 - Human leukocyte antigen class I and II alleles in non-Hodgkin lymphoma etiology

AU - Wang, Sophia S.

AU - Abdou, Amr M.

AU - Morton, Lindsay M.

AU - Thomas, Rasmi

AU - Cerhan, James R

AU - Gao, Xiaojiang

AU - Cozen, Wendy

AU - Rothman, Nathaniel

AU - Davis, Scott

AU - Severson, Richard K.

AU - Bernstein, Leslie

AU - Hartge, Patricia

AU - Carrington, Mary

PY - 2010/6/10

Y1 - 2010/6/10

N2 - Genome-wide association and candidate gene studies implicate different genetic variants within the 6p21 chromosomal region with different non-Hodgkin lymphoma (NHL) subtypes. Complementing these efforts, we conducted human leukocyte antigen (HLA) class I and class II genotyping among 610 NHL cases and 555 controls of non-Hispanic white descent from a US multicenter study. Allele-disease associations were assessed by logistic regression for NHL and its subtypes. Statistically significant associations between HLA and NHL subtypes include HLA-DRB1*0101 for follicular lymphoma (odds ratio [OR] = 2.14, P < .001), HLA-DRB1*0401 for diffuse large B-cell lymphoma (DLBCL; OR = 0.45, P = .006), and HLA-DRB1*13 and follicular lymphoma (OR = 0.48, P = .008). We further observed significant heterozygote advantage for HLA class I alleles and NHL, and particularly DLBCL (P trend = .01 for elevated risk with increasing number of homozygous alleles). Our results support a role for HLA in the etiology of NHL and its subtypes.

AB - Genome-wide association and candidate gene studies implicate different genetic variants within the 6p21 chromosomal region with different non-Hodgkin lymphoma (NHL) subtypes. Complementing these efforts, we conducted human leukocyte antigen (HLA) class I and class II genotyping among 610 NHL cases and 555 controls of non-Hispanic white descent from a US multicenter study. Allele-disease associations were assessed by logistic regression for NHL and its subtypes. Statistically significant associations between HLA and NHL subtypes include HLA-DRB1*0101 for follicular lymphoma (odds ratio [OR] = 2.14, P < .001), HLA-DRB1*0401 for diffuse large B-cell lymphoma (DLBCL; OR = 0.45, P = .006), and HLA-DRB1*13 and follicular lymphoma (OR = 0.48, P = .008). We further observed significant heterozygote advantage for HLA class I alleles and NHL, and particularly DLBCL (P trend = .01 for elevated risk with increasing number of homozygous alleles). Our results support a role for HLA in the etiology of NHL and its subtypes.

UR - http://www.scopus.com/inward/record.url?scp=77954719056&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77954719056&partnerID=8YFLogxK

U2 - 10.1182/blood-2010-01-266775

DO - 10.1182/blood-2010-01-266775

M3 - Article

VL - 115

SP - 4820

EP - 4823

JO - Blood

JF - Blood

SN - 0006-4971

IS - 23

ER -