Human leukocyte antigen class I and II alleles in non-Hodgkin lymphoma etiology

Sophia S. Wang; Amr M. Abdou; Lindsay M. Morton; Rasmi Thomas; James R. Cerhan; Xiaojiang Gao; Wendy Cozen; Nathaniel Rothman; Scott Davis; Richard K. Severson; Leslie Bernstein; Patricia Hartge; Mary Carrington

doi:10.1182/blood-2010-01-266775

Human leukocyte antigen class I and II alleles in non-Hodgkin lymphoma etiology

Sophia S. Wang, Amr M. Abdou, Lindsay M. Morton, Rasmi Thomas, James R. Cerhan, Xiaojiang Gao, Wendy Cozen, Nathaniel Rothman, Scott Davis, Richard K. Severson, Leslie Bernstein, Patricia Hartge, Mary Carrington

Quantitative Health Sciences

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

Genome-wide association and candidate gene studies implicate different genetic variants within the 6p21 chromosomal region with different non-Hodgkin lymphoma (NHL) subtypes. Complementing these efforts, we conducted human leukocyte antigen (HLA) class I and class II genotyping among 610 NHL cases and 555 controls of non-Hispanic white descent from a US multicenter study. Allele-disease associations were assessed by logistic regression for NHL and its subtypes. Statistically significant associations between HLA and NHL subtypes include HLA-DRB1*0101 for follicular lymphoma (odds ratio [OR] = 2.14, P < .001), HLA-DRB1*0401 for diffuse large B-cell lymphoma (DLBCL; OR = 0.45, P = .006), and HLA-DRB1*13 and follicular lymphoma (OR = 0.48, P = .008). We further observed significant heterozygote advantage for HLA class I alleles and NHL, and particularly DLBCL (P trend = .01 for elevated risk with increasing number of homozygous alleles). Our results support a role for HLA in the etiology of NHL and its subtypes.

Original language	English (US)
Pages (from-to)	4820-4823
Number of pages	4
Journal	Blood
Volume	115
Issue number	23
DOIs	https://doi.org/10.1182/blood-2010-01-266775
State	Published - Jun 10 2010

ASJC Scopus subject areas

Biochemistry
Immunology
Hematology
Cell Biology

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title = "Human leukocyte antigen class I and II alleles in non-Hodgkin lymphoma etiology",

abstract = "Genome-wide association and candidate gene studies implicate different genetic variants within the 6p21 chromosomal region with different non-Hodgkin lymphoma (NHL) subtypes. Complementing these efforts, we conducted human leukocyte antigen (HLA) class I and class II genotyping among 610 NHL cases and 555 controls of non-Hispanic white descent from a US multicenter study. Allele-disease associations were assessed by logistic regression for NHL and its subtypes. Statistically significant associations between HLA and NHL subtypes include HLA-DRB1*0101 for follicular lymphoma (odds ratio [OR] = 2.14, P < .001), HLA-DRB1*0401 for diffuse large B-cell lymphoma (DLBCL; OR = 0.45, P = .006), and HLA-DRB1*13 and follicular lymphoma (OR = 0.48, P = .008). We further observed significant heterozygote advantage for HLA class I alleles and NHL, and particularly DLBCL (P trend = .01 for elevated risk with increasing number of homozygous alleles). Our results support a role for HLA in the etiology of NHL and its subtypes.",

author = "Wang, {Sophia S.} and Abdou, {Amr M.} and Morton, {Lindsay M.} and Rasmi Thomas and Cerhan, {James R.} and Xiaojiang Gao and Wendy Cozen and Nathaniel Rothman and Scott Davis and Severson, {Richard K.} and Leslie Bernstein and Patricia Hartge and Mary Carrington",

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doi = "10.1182/blood-2010-01-266775",

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AU - Wang, Sophia S.

AU - Abdou, Amr M.

AU - Morton, Lindsay M.

AU - Thomas, Rasmi

AU - Cerhan, James R.

AU - Gao, Xiaojiang

AU - Cozen, Wendy

AU - Rothman, Nathaniel

AU - Davis, Scott

AU - Severson, Richard K.

AU - Bernstein, Leslie

AU - Hartge, Patricia

AU - Carrington, Mary

PY - 2010/6/10

Y1 - 2010/6/10

N2 - Genome-wide association and candidate gene studies implicate different genetic variants within the 6p21 chromosomal region with different non-Hodgkin lymphoma (NHL) subtypes. Complementing these efforts, we conducted human leukocyte antigen (HLA) class I and class II genotyping among 610 NHL cases and 555 controls of non-Hispanic white descent from a US multicenter study. Allele-disease associations were assessed by logistic regression for NHL and its subtypes. Statistically significant associations between HLA and NHL subtypes include HLA-DRB1*0101 for follicular lymphoma (odds ratio [OR] = 2.14, P < .001), HLA-DRB1*0401 for diffuse large B-cell lymphoma (DLBCL; OR = 0.45, P = .006), and HLA-DRB1*13 and follicular lymphoma (OR = 0.48, P = .008). We further observed significant heterozygote advantage for HLA class I alleles and NHL, and particularly DLBCL (P trend = .01 for elevated risk with increasing number of homozygous alleles). Our results support a role for HLA in the etiology of NHL and its subtypes.

AB - Genome-wide association and candidate gene studies implicate different genetic variants within the 6p21 chromosomal region with different non-Hodgkin lymphoma (NHL) subtypes. Complementing these efforts, we conducted human leukocyte antigen (HLA) class I and class II genotyping among 610 NHL cases and 555 controls of non-Hispanic white descent from a US multicenter study. Allele-disease associations were assessed by logistic regression for NHL and its subtypes. Statistically significant associations between HLA and NHL subtypes include HLA-DRB1*0101 for follicular lymphoma (odds ratio [OR] = 2.14, P < .001), HLA-DRB1*0401 for diffuse large B-cell lymphoma (DLBCL; OR = 0.45, P = .006), and HLA-DRB1*13 and follicular lymphoma (OR = 0.48, P = .008). We further observed significant heterozygote advantage for HLA class I alleles and NHL, and particularly DLBCL (P trend = .01 for elevated risk with increasing number of homozygous alleles). Our results support a role for HLA in the etiology of NHL and its subtypes.

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Human leukocyte antigen class I and II alleles in non-Hodgkin lymphoma etiology

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