Human leukocyte antigen class I and II alleles in non-Hodgkin lymphoma etiology

Sophia S. Wang, Amr M. Abdou, Lindsay M. Morton, Rasmi Thomas, James R. Cerhan, Xiaojiang Gao, Wendy Cozen, Nathaniel Rothman, Scott Davis, Richard K. Severson, Leslie Bernstein, Patricia Hartge, Mary Carrington

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52 Scopus citations

Abstract

Genome-wide association and candidate gene studies implicate different genetic variants within the 6p21 chromosomal region with different non-Hodgkin lymphoma (NHL) subtypes. Complementing these efforts, we conducted human leukocyte antigen (HLA) class I and class II genotyping among 610 NHL cases and 555 controls of non-Hispanic white descent from a US multicenter study. Allele-disease associations were assessed by logistic regression for NHL and its subtypes. Statistically significant associations between HLA and NHL subtypes include HLA-DRB1*0101 for follicular lymphoma (odds ratio [OR] = 2.14, P < .001), HLA-DRB1*0401 for diffuse large B-cell lymphoma (DLBCL; OR = 0.45, P = .006), and HLA-DRB1*13 and follicular lymphoma (OR = 0.48, P = .008). We further observed significant heterozygote advantage for HLA class I alleles and NHL, and particularly DLBCL (P trend = .01 for elevated risk with increasing number of homozygous alleles). Our results support a role for HLA in the etiology of NHL and its subtypes.

Original languageEnglish (US)
Pages (from-to)4820-4823
Number of pages4
JournalBlood
Volume115
Issue number23
DOIs
StatePublished - Jun 10 2010

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ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Cite this

Wang, S. S., Abdou, A. M., Morton, L. M., Thomas, R., Cerhan, J. R., Gao, X., Cozen, W., Rothman, N., Davis, S., Severson, R. K., Bernstein, L., Hartge, P., & Carrington, M. (2010). Human leukocyte antigen class I and II alleles in non-Hodgkin lymphoma etiology. Blood, 115(23), 4820-4823. https://doi.org/10.1182/blood-2010-01-266775