Human Leukocyte Antigen Class I and II Alleles and Risk of Cervical Neoplasia: Results from a Population-Based Study in Costa Rica

S. S. Wang, C. M. Wheeler, A. Hildesheim, M. Schiffman, R. Herrero, M. C. Bratti, M. E. Sherman, M. Alfaro, M. L. Hutchinson, J. Morales, A. Lorincz, R. D. Burk, M. Carrington, H. A. Erlich, R. J. Apple

Research output: Contribution to journalArticle

86 Scopus citations

Abstract

To examine human leukocyte antigen (HLA) involvement in the development of all grades of cervical neoplasia, a nested case-control study of 10,077 women in Guanacaste, Costa Rica, was conducted. Participants had invasive cervical cancer, high-grade squamous intraepithelial lesions (HSILs; n=166), or low-grade squamous intraepithelial lesions (LSILs); were positive for human papillomavirus (HPV) with no evidence of cervical neoplasia (n=320); or were HPV negative with no evidence of cervical neoplasia but with a history of high-risk sexual behavior (n=173). Compared with women who were HPV negative, women with HLA-DRB1*1301 were associated with decreased risk for cancer/HSILs (odds ratio [OR], 0.4; 95% confidence interval [CI], 0.2–0.7) and for LSILs/HPV (OR, 0.6; 95% CI, 0.3–0.9). Women with both HLA-B*07 and HLA-DQB1*0302 had an 8.2-fold increased risk for cancer/HSILs (95% CI, 1.8–37.2) and a 5.3-fold increased risk for LSILs/HPV (95% CI, 1.2–23.7). These results support the hypothesis that multiple risk alleles are needed in order to increase risk for cervical neoplasia, but a single protective allele may be sufficient for protection.

Original languageEnglish (US)
Pages (from-to)1310-1314
Number of pages5
JournalJournal of Infectious Diseases
Volume184
Issue number10
DOIs
StatePublished - Nov 2001

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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    Wang, S. S., Wheeler, C. M., Hildesheim, A., Schiffman, M., Herrero, R., Bratti, M. C., Sherman, M. E., Alfaro, M., Hutchinson, M. L., Morales, J., Lorincz, A., Burk, R. D., Carrington, M., Erlich, H. A., & Apple, R. J. (2001). Human Leukocyte Antigen Class I and II Alleles and Risk of Cervical Neoplasia: Results from a Population-Based Study in Costa Rica. Journal of Infectious Diseases, 184(10), 1310-1314. https://doi.org/10.1086/324209