Human Ir genes: Structure and function

T. A. Gonwa, B. M. Peterlin, J. D. Stobo

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The structural studies clearly indicate the existence of human Ia molecules which are similar to those delineated in mice. However, it appears that there may be more human than murine Ia molecules. The functional studies indicate that HLA-DR and HLA-DS molecules can function as restriction elements which determine reactivity to simple antigens as well as immunodominant determinants present in complex antigens. The mechanisms by which human Ia molecules control the expression of immune reactivity have only begun to be explored. The available studies implicate these molecules in determining the relative activity of helper vs suppressive influences in controlling specific immune reactivity as well as generalized, i.e., polyclonal antibody formation. Future studies will generate genetic and molecular maps characterizing the whole range of human Ir genes and Ia molecules and indicate how they function to modulate immune reactivity in humans.

Original languageEnglish (US)
Pages (from-to)71-96
Number of pages26
JournalAdvances in Immunology
VolumeVOL. 34
StatePublished - 1983
Externally publishedYes

Fingerprint

Genes
HLA-DQ Antigens
Antigens
Immunodominant Epitopes
HLA-DR Antigens
Antibody Formation
Molecular Biology

ASJC Scopus subject areas

  • Immunology

Cite this

Gonwa, T. A., Peterlin, B. M., & Stobo, J. D. (1983). Human Ir genes: Structure and function. Advances in Immunology, VOL. 34, 71-96.

Human Ir genes : Structure and function. / Gonwa, T. A.; Peterlin, B. M.; Stobo, J. D.

In: Advances in Immunology, Vol. VOL. 34, 1983, p. 71-96.

Research output: Contribution to journalArticle

Gonwa, TA, Peterlin, BM & Stobo, JD 1983, 'Human Ir genes: Structure and function', Advances in Immunology, vol. VOL. 34, pp. 71-96.
Gonwa TA, Peterlin BM, Stobo JD. Human Ir genes: Structure and function. Advances in Immunology. 1983;VOL. 34:71-96.
Gonwa, T. A. ; Peterlin, B. M. ; Stobo, J. D. / Human Ir genes : Structure and function. In: Advances in Immunology. 1983 ; Vol. VOL. 34. pp. 71-96.
@article{c08722b547be432e9b061f8fe552100a,
title = "Human Ir genes: Structure and function",
abstract = "The structural studies clearly indicate the existence of human Ia molecules which are similar to those delineated in mice. However, it appears that there may be more human than murine Ia molecules. The functional studies indicate that HLA-DR and HLA-DS molecules can function as restriction elements which determine reactivity to simple antigens as well as immunodominant determinants present in complex antigens. The mechanisms by which human Ia molecules control the expression of immune reactivity have only begun to be explored. The available studies implicate these molecules in determining the relative activity of helper vs suppressive influences in controlling specific immune reactivity as well as generalized, i.e., polyclonal antibody formation. Future studies will generate genetic and molecular maps characterizing the whole range of human Ir genes and Ia molecules and indicate how they function to modulate immune reactivity in humans.",
author = "Gonwa, {T. A.} and Peterlin, {B. M.} and Stobo, {J. D.}",
year = "1983",
language = "English (US)",
volume = "VOL. 34",
pages = "71--96",
journal = "Advances in Immunology",
issn = "0065-2776",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Human Ir genes

T2 - Structure and function

AU - Gonwa, T. A.

AU - Peterlin, B. M.

AU - Stobo, J. D.

PY - 1983

Y1 - 1983

N2 - The structural studies clearly indicate the existence of human Ia molecules which are similar to those delineated in mice. However, it appears that there may be more human than murine Ia molecules. The functional studies indicate that HLA-DR and HLA-DS molecules can function as restriction elements which determine reactivity to simple antigens as well as immunodominant determinants present in complex antigens. The mechanisms by which human Ia molecules control the expression of immune reactivity have only begun to be explored. The available studies implicate these molecules in determining the relative activity of helper vs suppressive influences in controlling specific immune reactivity as well as generalized, i.e., polyclonal antibody formation. Future studies will generate genetic and molecular maps characterizing the whole range of human Ir genes and Ia molecules and indicate how they function to modulate immune reactivity in humans.

AB - The structural studies clearly indicate the existence of human Ia molecules which are similar to those delineated in mice. However, it appears that there may be more human than murine Ia molecules. The functional studies indicate that HLA-DR and HLA-DS molecules can function as restriction elements which determine reactivity to simple antigens as well as immunodominant determinants present in complex antigens. The mechanisms by which human Ia molecules control the expression of immune reactivity have only begun to be explored. The available studies implicate these molecules in determining the relative activity of helper vs suppressive influences in controlling specific immune reactivity as well as generalized, i.e., polyclonal antibody formation. Future studies will generate genetic and molecular maps characterizing the whole range of human Ir genes and Ia molecules and indicate how they function to modulate immune reactivity in humans.

UR - http://www.scopus.com/inward/record.url?scp=0020971453&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020971453&partnerID=8YFLogxK

M3 - Article

C2 - 6416037

AN - SCOPUS:0020971453

VL - VOL. 34

SP - 71

EP - 96

JO - Advances in Immunology

JF - Advances in Immunology

SN - 0065-2776

ER -