TY - JOUR
T1 - Human erythrocyte catechol-o-methyltransferase
T2 - Correlation with lung and kidney activity
AU - Weinshilboum, Richard M.
N1 - Funding Information:
I thank Fredrick Raymond, Joel Dunnette, Luanne Wussow and my colleagues from the Departments of Surgery and Pathology for their assistance with these studies . These studies were supported in part by NIH grants NS 11014 and HL 17487 . Dr . Weinshilboum is an Established Investigator of the American Heart Association .
PY - 1978/2
Y1 - 1978/2
N2 - Catechol-O-methyltransferase (COMT) activity measured in homogenates of human lung or renal cortical tissue was approximately an order of magnitude greater than the enzyme activity in human erythrocytes. Lung and blood enzyme activities varied from individual to individual over a 5-7 fold range. There was a highly significant correlation between the COMT activity in erythrocytes and the enzyme activity in lung (r = 0.59, P < .001, N = 29) and kidney (r = 0.81, P < .005, N = 12) of the same subjects. These results suggest that the relative COMT activity in lung and kidney might be predicted by the measurement of the enzyme activity in blood and raise the possibility that individual variation in the metabolism of endogenous catecholamines and catechol drugs in man may result in part from variations in COMT activity.
AB - Catechol-O-methyltransferase (COMT) activity measured in homogenates of human lung or renal cortical tissue was approximately an order of magnitude greater than the enzyme activity in human erythrocytes. Lung and blood enzyme activities varied from individual to individual over a 5-7 fold range. There was a highly significant correlation between the COMT activity in erythrocytes and the enzyme activity in lung (r = 0.59, P < .001, N = 29) and kidney (r = 0.81, P < .005, N = 12) of the same subjects. These results suggest that the relative COMT activity in lung and kidney might be predicted by the measurement of the enzyme activity in blood and raise the possibility that individual variation in the metabolism of endogenous catecholamines and catechol drugs in man may result in part from variations in COMT activity.
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U2 - 10.1016/0024-3205(78)90343-0
DO - 10.1016/0024-3205(78)90343-0
M3 - Article
C2 - 625202
AN - SCOPUS:0017798885
SN - 0024-3205
VL - 22
SP - 625
EP - 630
JO - Life Sciences
JF - Life Sciences
IS - 7
ER -