Human erythrocyte catechol-o-methyltransferase

Correlation with lung and kidney activity

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Catechol-O-methyltransferase (COMT) activity measured in homogenates of human lung or renal cortical tissue was approximately an order of magnitude greater than the enzyme activity in human erythrocytes. Lung and blood enzyme activities varied from individual to individual over a 5-7 fold range. There was a highly significant correlation between the COMT activity in erythrocytes and the enzyme activity in lung (r = 0.59, P < .001, N = 29) and kidney (r = 0.81, P < .005, N = 12) of the same subjects. These results suggest that the relative COMT activity in lung and kidney might be predicted by the measurement of the enzyme activity in blood and raise the possibility that individual variation in the metabolism of endogenous catecholamines and catechol drugs in man may result in part from variations in COMT activity.

Original languageEnglish (US)
Pages (from-to)625-630
Number of pages6
JournalLife Sciences
Volume22
Issue number7
DOIs
StatePublished - 1978

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Catechol O-Methyltransferase
Methyltransferases
Enzyme activity
Erythrocytes
Kidney
Lung
Enzymes
Blood
Metabolism
Human Activities
Catecholamines
Tissue
catechol
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology

Cite this

Human erythrocyte catechol-o-methyltransferase : Correlation with lung and kidney activity. / Weinshilboum, Richard M.

In: Life Sciences, Vol. 22, No. 7, 1978, p. 625-630.

Research output: Contribution to journalArticle

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