Hormonal responses to short term fasting in postmenopausal women

I. Z. Beitins, A. Barkan, A. Klibanski, N. Kyung, S. M. Reppert, T. M. Badger, Johannes D Veldhuis, J. W. McArthur

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Urinary excretion of gonadotropins increased during fasting. We investigated whether this increase results from increased pituitary secretion of LH and FSH or from altered renal excretion of protein molecules. To this end, we studied urinary gonadotropin excretion, serum gonadotropin levels, and pituitary responsiveness of LHRH during control, 10-day fasting, and refeeding periods in 10 mildly obese postmenopausal women. Additionally, we measured urinary cortisol and estriol excretion and circulating levels of dehydroepiandrosterone sulfate, estradiol, estrone, melatonin, norepinephrine, epinephrine, and dopamine during the control, fasting, and refeeding periods. While urinary excretion of gonadotropins increased markedly during fasting, there were no significant changes in serum gonadotropin levels or in the pituitary sensitivity to LHRH. Plasma norepinephrine and serum melatonin increased significantly during fasting, but serum and urinary estrogens, indices of adrenal activity, and plasma levels of epinephrine and dopamine did not change. These results show that the stress of short term fasting selectively activates only certain components of the neuroendocrine system without any appreciable changes in the function of the gonadotropin-secreting system. Fasting-induced gonadotropinuria is probably explained by altered renal handling of gonadotropin molecules.

Original languageEnglish (US)
Pages (from-to)1120-1126
Number of pages7
JournalJournal of Clinical Endocrinology and Metabolism
Volume60
Issue number6
StatePublished - 1985
Externally publishedYes

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Gonadotropins
Fasting
Melatonin
Serum
Gonadotropin-Releasing Hormone
Epinephrine
Dopamine
Norepinephrine
Pituitary Gonadotropins
Plasmas
Estriol
Dehydroepiandrosterone Sulfate
Neurosecretory Systems
Molecules
Estrone
Hydrocortisone
Estradiol
Estrogens
Kidney
Proteins

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Beitins, I. Z., Barkan, A., Klibanski, A., Kyung, N., Reppert, S. M., Badger, T. M., ... McArthur, J. W. (1985). Hormonal responses to short term fasting in postmenopausal women. Journal of Clinical Endocrinology and Metabolism, 60(6), 1120-1126.

Hormonal responses to short term fasting in postmenopausal women. / Beitins, I. Z.; Barkan, A.; Klibanski, A.; Kyung, N.; Reppert, S. M.; Badger, T. M.; Veldhuis, Johannes D; McArthur, J. W.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 60, No. 6, 1985, p. 1120-1126.

Research output: Contribution to journalArticle

Beitins, IZ, Barkan, A, Klibanski, A, Kyung, N, Reppert, SM, Badger, TM, Veldhuis, JD & McArthur, JW 1985, 'Hormonal responses to short term fasting in postmenopausal women', Journal of Clinical Endocrinology and Metabolism, vol. 60, no. 6, pp. 1120-1126.
Beitins IZ, Barkan A, Klibanski A, Kyung N, Reppert SM, Badger TM et al. Hormonal responses to short term fasting in postmenopausal women. Journal of Clinical Endocrinology and Metabolism. 1985;60(6):1120-1126.
Beitins, I. Z. ; Barkan, A. ; Klibanski, A. ; Kyung, N. ; Reppert, S. M. ; Badger, T. M. ; Veldhuis, Johannes D ; McArthur, J. W. / Hormonal responses to short term fasting in postmenopausal women. In: Journal of Clinical Endocrinology and Metabolism. 1985 ; Vol. 60, No. 6. pp. 1120-1126.
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