Homology modeling of GPCRs.

John Simms, Nathan E. Hall, Polo H.C. Lam, Laurence J. Miller, Arthur Christopoulos, Ruben Abagyan, Patrick M. Sexton

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Over 1,000 sequences likely to encode G protein-coupled receptors (GPCRs) are currently available in publicly accessible and proprietary databases and this number may grow with the refinement of a number of different genomes. However, despite recent efforts in the crystallization of these proteins, homology modeling approaches are becoming widely used as a method for obtaining quantitative and qualitative information for structure-based drug design as well as the interpretation of experimental data.

Original languageEnglish (US)
Pages (from-to)97-113
Number of pages17
JournalMethods in molecular biology (Clifton, N.J.)
Volume552
DOIs
StatePublished - 2009

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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