Homology modeling of GPCRs.

John Simms; Nathan E. Hall; Polo H.C. Lam; Laurence J. Miller; Arthur Christopoulos; Ruben Abagyan; Patrick M. Sexton

doi:10.1007/978-1-60327-317-6_7

Homology modeling of GPCRs.

John Simms, Nathan E. Hall, Polo H.C. Lam, Laurence J. Miller, Arthur Christopoulos, Ruben Abagyan, Patrick M. Sexton

Gastroenterology and Hepatology

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Over 1,000 sequences likely to encode G protein-coupled receptors (GPCRs) are currently available in publicly accessible and proprietary databases and this number may grow with the refinement of a number of different genomes. However, despite recent efforts in the crystallization of these proteins, homology modeling approaches are becoming widely used as a method for obtaining quantitative and qualitative information for structure-based drug design as well as the interpretation of experimental data.

Original language	English (US)
Pages (from-to)	97-113
Number of pages	17
Journal	Methods in molecular biology (Clifton, N.J.)
Volume	552
DOIs	https://doi.org/10.1007/978-1-60327-317-6_7
State	Published - 2009

ASJC Scopus subject areas

Molecular Biology
Genetics

Access to Document

10.1007/978-1-60327-317-6_7

Cite this

@article{3e976284921043dabfd83a7b7b328ba5,

title = "Homology modeling of GPCRs.",

abstract = "Over 1,000 sequences likely to encode G protein-coupled receptors (GPCRs) are currently available in publicly accessible and proprietary databases and this number may grow with the refinement of a number of different genomes. However, despite recent efforts in the crystallization of these proteins, homology modeling approaches are becoming widely used as a method for obtaining quantitative and qualitative information for structure-based drug design as well as the interpretation of experimental data.",

author = "John Simms and Hall, {Nathan E.} and Lam, {Polo H.C.} and Miller, {Laurence J.} and Arthur Christopoulos and Ruben Abagyan and Sexton, {Patrick M.}",

year = "2009",

doi = "10.1007/978-1-60327-317-6_7",

language = "English (US)",

volume = "552",

pages = "97--113",

journal = "Methods in molecular biology (Clifton, N.J.)",

issn = "1064-3745",

publisher = "Humana Press",

}

TY - JOUR

T1 - Homology modeling of GPCRs.

AU - Simms, John

AU - Hall, Nathan E.

AU - Lam, Polo H.C.

AU - Miller, Laurence J.

AU - Christopoulos, Arthur

AU - Abagyan, Ruben

AU - Sexton, Patrick M.

PY - 2009

Y1 - 2009

N2 - Over 1,000 sequences likely to encode G protein-coupled receptors (GPCRs) are currently available in publicly accessible and proprietary databases and this number may grow with the refinement of a number of different genomes. However, despite recent efforts in the crystallization of these proteins, homology modeling approaches are becoming widely used as a method for obtaining quantitative and qualitative information for structure-based drug design as well as the interpretation of experimental data.

AB - Over 1,000 sequences likely to encode G protein-coupled receptors (GPCRs) are currently available in publicly accessible and proprietary databases and this number may grow with the refinement of a number of different genomes. However, despite recent efforts in the crystallization of these proteins, homology modeling approaches are becoming widely used as a method for obtaining quantitative and qualitative information for structure-based drug design as well as the interpretation of experimental data.

UR - http://www.scopus.com/inward/record.url?scp=67650351973&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67650351973&partnerID=8YFLogxK

U2 - 10.1007/978-1-60327-317-6_7

DO - 10.1007/978-1-60327-317-6_7

M3 - Article

C2 - 19513644

AN - SCOPUS:67650351973

SN - 1064-3745

VL - 552

SP - 97

EP - 113

JO - Methods in molecular biology (Clifton, N.J.)

JF - Methods in molecular biology (Clifton, N.J.)

ER -

Homology modeling of GPCRs.

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this