HLA-DR antigen frequencies in a North Indian type I diabetic population

E. Bhatia; N. K. Mehra; V. Taneja; M. C. Vaidya; M. M. Ahuja

doi:10.2337/diab.34.6.565

HLA-DR antigen frequencies in a North Indian type I diabetic population

E. Bhatia, N. K. Mehra, V. Taneja, M. C. Vaidya, M. M. Ahuja

Immunology

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26 Scopus citations

Abstract

Eighty-eight North Indian patients with type I, insulin-dependent diabetes mellitus (IDDM) and 113 unaffected individuals were typed for HLA-DR antigens from DR1 to DR7. The frequency of HLA-DR3 was significantly increased in the patients as compared with the controls (78.4% versus 25.7%, corrected P = 1.68 x 10^-12), the relative risk (RR) of 10.52 being much higher than that reported in the Western IDDM population. HLA-DR2 showed a significant negative association (RR = 0.18, corrected P = 1.03 x 10^-5), but DR4 had no relationship with IDDM in the present study (RR = 1.12, P = 0.12). These results emphasize the differences in HLA-IDDM associations among different ethnic groups.

Original language	English (US)
Pages (from-to)	565-567
Number of pages	3
Journal	Diabetes
Volume	34
Issue number	6
DOIs	https://doi.org/10.2337/diab.34.6.565
State	Published - 1985

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism

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title = "HLA-DR antigen frequencies in a North Indian type I diabetic population",

abstract = "Eighty-eight North Indian patients with type I, insulin-dependent diabetes mellitus (IDDM) and 113 unaffected individuals were typed for HLA-DR antigens from DR1 to DR7. The frequency of HLA-DR3 was significantly increased in the patients as compared with the controls (78.4% versus 25.7%, corrected P = 1.68 x 10-12), the relative risk (RR) of 10.52 being much higher than that reported in the Western IDDM population. HLA-DR2 showed a significant negative association (RR = 0.18, corrected P = 1.03 x 10-5), but DR4 had no relationship with IDDM in the present study (RR = 1.12, P = 0.12). These results emphasize the differences in HLA-IDDM associations among different ethnic groups.",

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T1 - HLA-DR antigen frequencies in a North Indian type I diabetic population

AU - Bhatia, E.

AU - Mehra, N. K.

AU - Taneja, V.

AU - Vaidya, M. C.

AU - Ahuja, M. M.

PY - 1985

Y1 - 1985

N2 - Eighty-eight North Indian patients with type I, insulin-dependent diabetes mellitus (IDDM) and 113 unaffected individuals were typed for HLA-DR antigens from DR1 to DR7. The frequency of HLA-DR3 was significantly increased in the patients as compared with the controls (78.4% versus 25.7%, corrected P = 1.68 x 10-12), the relative risk (RR) of 10.52 being much higher than that reported in the Western IDDM population. HLA-DR2 showed a significant negative association (RR = 0.18, corrected P = 1.03 x 10-5), but DR4 had no relationship with IDDM in the present study (RR = 1.12, P = 0.12). These results emphasize the differences in HLA-IDDM associations among different ethnic groups.

AB - Eighty-eight North Indian patients with type I, insulin-dependent diabetes mellitus (IDDM) and 113 unaffected individuals were typed for HLA-DR antigens from DR1 to DR7. The frequency of HLA-DR3 was significantly increased in the patients as compared with the controls (78.4% versus 25.7%, corrected P = 1.68 x 10-12), the relative risk (RR) of 10.52 being much higher than that reported in the Western IDDM population. HLA-DR2 showed a significant negative association (RR = 0.18, corrected P = 1.03 x 10-5), but DR4 had no relationship with IDDM in the present study (RR = 1.12, P = 0.12). These results emphasize the differences in HLA-IDDM associations among different ethnic groups.

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HLA-DR antigen frequencies in a North Indian type I diabetic population

Abstract

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