HLA-DR antigen frequencies in a North Indian type I diabetic population

E. Bhatia, N. K. Mehra, V. Taneja, M. C. Vaidya, M. M. Ahuja

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Eighty-eight North Indian patients with type I, insulin-dependent diabetes mellitus (IDDM) and 113 unaffected individuals were typed for HLA-DR antigens from DR1 to DR7. The frequency of HLA-DR3 was significantly increased in the patients as compared with the controls (78.4% versus 25.7%, corrected P = 1.68 x 10-12), the relative risk (RR) of 10.52 being much higher than that reported in the Western IDDM population. HLA-DR2 showed a significant negative association (RR = 0.18, corrected P = 1.03 x 10-5), but DR4 had no relationship with IDDM in the present study (RR = 1.12, P = 0.12). These results emphasize the differences in HLA-IDDM associations among different ethnic groups.

Original languageEnglish (US)
Pages (from-to)565-567
Number of pages3
JournalDiabetes
Volume34
Issue number6
DOIs
StatePublished - Jan 1 1985

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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