HLA Antigens in Migraine

Brian P. O'Neill; Janet J. Kapur; Armin E. Good

doi:10.1111/j.1526-4610.1979.hed1902071.x

HLA Antigens in Migraine

Brian P. O'Neill, Janet J. Kapur, Armin E. Good

Neurology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

SYNOPSIS Fifty consecutive patients with migraine headaches were evaluated for the presence of 10 HLA‐A and 14 HLA‐B antigens by means of the microlymphocytotoxicity assay. Comparisons were made between classical and common migraine, and between patients with and without a family history of migraine. All groups of patients showed an association with B8 and B27, which failed to reach clinical significance. This data suggests that the multifactorial inheritance postulated for migraine probably does not require the participation of the HLA‐A or B locus of the major histocompatibility complex.

Original language	English (US)
Pages (from-to)	71-73
Number of pages	3
Journal	Headache: The Journal of Head and Face Pain
Volume	19
Issue number	2
DOIs	https://doi.org/10.1111/j.1526-4610.1979.hed1902071.x
State	Published - Mar 1979

ASJC Scopus subject areas

Neurology
Clinical Neurology

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year = "1979",

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AU - Kapur, Janet J.

AU - Good, Armin E.

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N2 - SYNOPSIS Fifty consecutive patients with migraine headaches were evaluated for the presence of 10 HLA‐A and 14 HLA‐B antigens by means of the microlymphocytotoxicity assay. Comparisons were made between classical and common migraine, and between patients with and without a family history of migraine. All groups of patients showed an association with B8 and B27, which failed to reach clinical significance. This data suggests that the multifactorial inheritance postulated for migraine probably does not require the participation of the HLA‐A or B locus of the major histocompatibility complex.

AB - SYNOPSIS Fifty consecutive patients with migraine headaches were evaluated for the presence of 10 HLA‐A and 14 HLA‐B antigens by means of the microlymphocytotoxicity assay. Comparisons were made between classical and common migraine, and between patients with and without a family history of migraine. All groups of patients showed an association with B8 and B27, which failed to reach clinical significance. This data suggests that the multifactorial inheritance postulated for migraine probably does not require the participation of the HLA‐A or B locus of the major histocompatibility complex.

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HLA Antigens in Migraine

Abstract

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