Histopathologic pattern and clinical features of rheumatoid arthritis-associated interstitial lung disease

Hyun Kyung Lee, Dong Soon Kim, Bin Yoo, Joon Beom Seo, Jae Yoon Rho, Thomas V. Colby, Masanori Kitaichi

Research output: Contribution to journalArticle

258 Citations (Scopus)

Abstract

Study objectives: To investigate the histopathologic pattern and clinical features of patients with rheumatoid arthritis (RA)-associated interstitial lung disease (ILD) according to the American Thoracic Society (ATS)/European Respiratory Society consensus classification of idiopathic interstitial pneumonia. Design: Retrospective review. Setting: Two thousand-bed, university-affiliated, tertiary referral center. Patients: Eighteen patients with RA who underwent surgical lung biopsy (SLBx) for suspected ILD. Method: SLBx specimens were reviewed and reclassified by three lung pathologists according to the ATS/European Respiratory Society classification. Clinical features and follow-up courses for the usual interstitial pneumonia (UIP) pattern and the nonspecific interstitial pneumonia (NSIP) pattern were compared. Results: The histopathologic patterns were diverse: 10 patients with the UIP pattern, 6 patients with the NSIP pattern, and 2 patients with inflammatory airway disease with the organizing pneumonia pattern. RA preceded ILD in the majority of patients (n = 12). In three patients, ILD preceded RA; in three patients, both conditions were diagnosed simultaneously. The majority (n = 13) of patients had a restrictive defect with or without low diffusion capacity of the lung for carbon monoxide (DLCo) on pulmonary function testing; 2 patients had only low DLCO. The UIP and NSIP groups were significantly different in their male/female ratios (8/2 vs 0/6, respectively; p = 0.007) and smoking history (current/former or nonsmokers, 8/2 vs 0/6; p = 0.007). Many of the patients with the UIP pattern had typical high-resolution CT features of UIP. Five patients with the UIP pattern died, whereas no deaths occurred among patients with the NSIP pattern during median follow-up durations of 4.2 years and 3.7 years, respectively. Conclusions: The histopathologic type of RA-ILD was diverse; in our study population, the UIP pattern seemed to be more prevalent than the NSIP pattern.

Original languageEnglish (US)
Pages (from-to)2019-2027
Number of pages9
JournalChest
Volume127
Issue number6
DOIs
StatePublished - Jun 2005

Fingerprint

Interstitial Lung Diseases
Rheumatoid Arthritis
Idiopathic Pulmonary Fibrosis
Lung
Idiopathic Interstitial Pneumonias
Lung Volume Measurements
Carbon Monoxide
Tertiary Care Centers
Pneumonia
Consensus
Thorax

Keywords

  • Bronchiolitis
  • Nonspecific interstitial pneumonia
  • Prognosis
  • Rheumatoid arthritis
  • Surgical lung biopsy
  • Usual interstitial pneumonia

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Lee, H. K., Kim, D. S., Yoo, B., Seo, J. B., Rho, J. Y., Colby, T. V., & Kitaichi, M. (2005). Histopathologic pattern and clinical features of rheumatoid arthritis-associated interstitial lung disease. Chest, 127(6), 2019-2027. https://doi.org/10.1378/chest.127.6.2019

Histopathologic pattern and clinical features of rheumatoid arthritis-associated interstitial lung disease. / Lee, Hyun Kyung; Kim, Dong Soon; Yoo, Bin; Seo, Joon Beom; Rho, Jae Yoon; Colby, Thomas V.; Kitaichi, Masanori.

In: Chest, Vol. 127, No. 6, 06.2005, p. 2019-2027.

Research output: Contribution to journalArticle

Lee, HK, Kim, DS, Yoo, B, Seo, JB, Rho, JY, Colby, TV & Kitaichi, M 2005, 'Histopathologic pattern and clinical features of rheumatoid arthritis-associated interstitial lung disease', Chest, vol. 127, no. 6, pp. 2019-2027. https://doi.org/10.1378/chest.127.6.2019
Lee, Hyun Kyung ; Kim, Dong Soon ; Yoo, Bin ; Seo, Joon Beom ; Rho, Jae Yoon ; Colby, Thomas V. ; Kitaichi, Masanori. / Histopathologic pattern and clinical features of rheumatoid arthritis-associated interstitial lung disease. In: Chest. 2005 ; Vol. 127, No. 6. pp. 2019-2027.
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abstract = "Study objectives: To investigate the histopathologic pattern and clinical features of patients with rheumatoid arthritis (RA)-associated interstitial lung disease (ILD) according to the American Thoracic Society (ATS)/European Respiratory Society consensus classification of idiopathic interstitial pneumonia. Design: Retrospective review. Setting: Two thousand-bed, university-affiliated, tertiary referral center. Patients: Eighteen patients with RA who underwent surgical lung biopsy (SLBx) for suspected ILD. Method: SLBx specimens were reviewed and reclassified by three lung pathologists according to the ATS/European Respiratory Society classification. Clinical features and follow-up courses for the usual interstitial pneumonia (UIP) pattern and the nonspecific interstitial pneumonia (NSIP) pattern were compared. Results: The histopathologic patterns were diverse: 10 patients with the UIP pattern, 6 patients with the NSIP pattern, and 2 patients with inflammatory airway disease with the organizing pneumonia pattern. RA preceded ILD in the majority of patients (n = 12). In three patients, ILD preceded RA; in three patients, both conditions were diagnosed simultaneously. The majority (n = 13) of patients had a restrictive defect with or without low diffusion capacity of the lung for carbon monoxide (DLCo) on pulmonary function testing; 2 patients had only low DLCO. The UIP and NSIP groups were significantly different in their male/female ratios (8/2 vs 0/6, respectively; p = 0.007) and smoking history (current/former or nonsmokers, 8/2 vs 0/6; p = 0.007). Many of the patients with the UIP pattern had typical high-resolution CT features of UIP. Five patients with the UIP pattern died, whereas no deaths occurred among patients with the NSIP pattern during median follow-up durations of 4.2 years and 3.7 years, respectively. Conclusions: The histopathologic type of RA-ILD was diverse; in our study population, the UIP pattern seemed to be more prevalent than the NSIP pattern.",
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N2 - Study objectives: To investigate the histopathologic pattern and clinical features of patients with rheumatoid arthritis (RA)-associated interstitial lung disease (ILD) according to the American Thoracic Society (ATS)/European Respiratory Society consensus classification of idiopathic interstitial pneumonia. Design: Retrospective review. Setting: Two thousand-bed, university-affiliated, tertiary referral center. Patients: Eighteen patients with RA who underwent surgical lung biopsy (SLBx) for suspected ILD. Method: SLBx specimens were reviewed and reclassified by three lung pathologists according to the ATS/European Respiratory Society classification. Clinical features and follow-up courses for the usual interstitial pneumonia (UIP) pattern and the nonspecific interstitial pneumonia (NSIP) pattern were compared. Results: The histopathologic patterns were diverse: 10 patients with the UIP pattern, 6 patients with the NSIP pattern, and 2 patients with inflammatory airway disease with the organizing pneumonia pattern. RA preceded ILD in the majority of patients (n = 12). In three patients, ILD preceded RA; in three patients, both conditions were diagnosed simultaneously. The majority (n = 13) of patients had a restrictive defect with or without low diffusion capacity of the lung for carbon monoxide (DLCo) on pulmonary function testing; 2 patients had only low DLCO. The UIP and NSIP groups were significantly different in their male/female ratios (8/2 vs 0/6, respectively; p = 0.007) and smoking history (current/former or nonsmokers, 8/2 vs 0/6; p = 0.007). Many of the patients with the UIP pattern had typical high-resolution CT features of UIP. Five patients with the UIP pattern died, whereas no deaths occurred among patients with the NSIP pattern during median follow-up durations of 4.2 years and 3.7 years, respectively. Conclusions: The histopathologic type of RA-ILD was diverse; in our study population, the UIP pattern seemed to be more prevalent than the NSIP pattern.

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