Hippocampal progenitor cells express nestin following cerebral ischemia in rats

Zhen He, Li Cui, James F. Meschia, Dennis W. Dickson, Thomas G. Brott, James W. Simpkins, Arthur L. Day, Michael McKinney

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


This study addresses whether hippocampal progenitor cells express nestin following cerebral ischemia in rats. Cell counts within the hippocampal hilus were significantly greater following severe (eight-vessel occlusion) ischemia than following intermediate (four-vessel occlusion) ischemia (1527 ± 87/mm2 vs. 918 ± 71/mm2). Bromedeoxyuridine- positive cell counts were significantly higher with severe ischemia than with intermediate ischemia or in sham-operated animals, respectively (368 ± 45, 43 ± 14 and 7 ± 1/mm2). In the eight-vessel occlusion group, 47 ± 8/mm2 bromedeoxyuridine-labeled cells expressed nestin, significantly higher than in the four-vessel occlusion group and sham-operated animals (1 ± 1 and 1 ± 0/mm2, P < 0.01 vs. eight-vessel occlusion, respectively). Confocal microscopy verified that a subset of the bromedeoxyuridine-positive cells expressed nestin. In conclusion, severe ischemia elicits nestin expression in hippocampal progenitor cells in rats.

Original languageEnglish (US)
Pages (from-to)1541-1544
Number of pages4
Issue number14
StatePublished - Sep 28 2005


  • Bromedeoxyuridine labeling
  • Global ischemia
  • Hippocampal progenitor cells
  • Nestin
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)


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