Hilar cholangiocarcinoma

Victor M. Zaydfudim, Charles B. Rosen, David M. Nagorney

Research output: Contribution to journalReview article

28 Scopus citations

Abstract

Optimal treatment of hilar cholangiocarcinoma depends on location of the cancer and extent of biliary and vascular involvement. Candidates for resection or transplantation must be evaluated and managed by a multidisciplinary team at a high-volume hepatobiliary center. Success requires absence of distant nodal or extrahepatic metastases and an adequate functional liver remnant with a negative ductal margin. Ipsilateral portal vein resection and reconstruction should be performed in patients with venous involvement. Neoadjuvant chemoradiation and liver transplantation is the best treatment option for patients with unresectable hilar cholangiocarcinoma without nodal or distant metastases and for patients with underlying chronic liver disease.

Original languageEnglish (US)
Pages (from-to)247-263
Number of pages17
JournalSurgical Oncology Clinics of North America
Volume23
Issue number2
DOIs
StatePublished - Apr 1 2014

Keywords

  • Hepatic resection
  • Hilar cholangiocarcinoma
  • Liver transplantation
  • Vascular resection

ASJC Scopus subject areas

  • Surgery
  • Oncology

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    Zaydfudim, V. M., Rosen, C. B., & Nagorney, D. M. (2014). Hilar cholangiocarcinoma. Surgical Oncology Clinics of North America, 23(2), 247-263. https://doi.org/10.1016/j.soc.2013.10.005