Anormalidades neuroendocrinas en el síndrome de poliquistosis ov́rica

Translated title of the contribution: Highlights on the neuroendocrine adaptation in polycistic ovarian syndrome

M. C. García Rudaz, Johannes D Veldhuis, M. B. Barontini

Research output: Contribution to journalArticle

Abstract

Polycystic ovarian disease (PCO) is the most common primary reproductive abnormality associated with impaired fertility in young women. This syndrome is hallmarked by hypersecretion of luteinizing hormone (LH), ovarian theca-cell hypertrophy, hyperandrogenemia, oligo- or anovulation, amenorrhea, hyperinsulinism, dyslipidermia and increased cardiovascular risk. Within this constellation, cardinal pathophysiological features are hyperinsulinism and excessive LH secretion. At least four categories of insulin-depleting regimens are able to improve or normalize various facets of reproductive impairment in PCO. However, the mechanistic bases of LH hypersecretion and insulin resistance, and the manner (if any) whereby the foregoing major pathophysiologies are causally interlinked are unknown.

Original languageSpanish
Pages (from-to)113-124
Number of pages12
JournalCuadernos de Medicina Reproductiva
Volume9
Issue number1
StatePublished - 2003

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Luteinizing Hormone
Ovarian Diseases
Hyperinsulinism
Theca Cells
Anovulation
Amenorrhea
Hypertrophy
Fertility
Insulin Resistance
Insulin

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

García Rudaz, M. C., Veldhuis, J. D., & Barontini, M. B. (2003). Anormalidades neuroendocrinas en el síndrome de poliquistosis ov́rica. Cuadernos de Medicina Reproductiva, 9(1), 113-124.

Anormalidades neuroendocrinas en el síndrome de poliquistosis ov́rica. / García Rudaz, M. C.; Veldhuis, Johannes D; Barontini, M. B.

In: Cuadernos de Medicina Reproductiva, Vol. 9, No. 1, 2003, p. 113-124.

Research output: Contribution to journalArticle

García Rudaz, MC, Veldhuis, JD & Barontini, MB 2003, 'Anormalidades neuroendocrinas en el síndrome de poliquistosis ov́rica', Cuadernos de Medicina Reproductiva, vol. 9, no. 1, pp. 113-124.
García Rudaz, M. C. ; Veldhuis, Johannes D ; Barontini, M. B. / Anormalidades neuroendocrinas en el síndrome de poliquistosis ov́rica. In: Cuadernos de Medicina Reproductiva. 2003 ; Vol. 9, No. 1. pp. 113-124.
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