High-risk human papillomavirus is sexually transmitted: Evidence from a follow-up study of virgins starting sexual activity (Intercourse)

Susanne Krüger Kjaer, Bryce Chackerian, Adriaan J.C. Van Den Brule, Edith I. Svare, Gerson Paull, Jan M.M. Walbomers, John T. Schiller, Johannes E. Bock, Mark E. Sherman, Douglas R. Lowy, Chris L.M. Meijer

Research output: Contribution to journalArticle

197 Citations (Scopus)

Abstract

Genital human papillomavirus (HPV) infection is generally considered to be sexually transmitted. However, nonsexual spread of the virus has also been suggested. The goal of this study was to assess: (a) the role of sexual intercourse in the transmission of HPV; (b) the determinants for seroconversion; and (c) the correlation between HPV DNA, abnormal cervical cytology, and serological response to HPV16. One hundred virgins and 105 monogamous women were randomly selected from a population-based cohort study in Copenhagen, Denmark, in which the women were examined twice with 2-year interval (interview, cervical swabs, Pap smear, blood samples). The presence of HPV DNA was determined by GP5+/6+ primers based HPV-PCR-EIA. HPV 16 virus-like particles (VLP) antibodies were detected by ELISA. All of the virgins were both HPV DNA negative and seronegative to VLP16, except for one woman who was weakly HPV 6 DNA positive. Only those virgins who initiated sexual activity became HPV DNA positive and/or VLP16 positive. The most important determinant of HPV DNA acquisition was the number of partners between the two examinations. The only significant risk factor for HPV 16 VLP seroconversion among women acquiring HPV DNA was HPV type. Our results show that sexual intercourse is important in the transmission of HPV, and that HPV 16 VLP seroconversion and the development of cervical lesions only occur after HPV transmission. Remarkably, no cervical lesions were found in HPV 16 DNA positive women who had seroconverted. Although based on small numbers, this may suggest that the development of antibodies had a protective effect.

Original languageEnglish (US)
Pages (from-to)101-106
Number of pages6
JournalCancer Epidemiology Biomarkers and Prevention
Volume10
Issue number2
StatePublished - 2001
Externally publishedYes

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Coitus
Sexual Behavior
Papillomaviridae
Human papillomavirus 16
DNA
Virion
Human papillomavirus 6
Papanicolaou Test
Papillomavirus Infections
Antibodies
Denmark
Cell Biology
Cohort Studies
Enzyme-Linked Immunosorbent Assay
Interviews

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Kjaer, S. K., Chackerian, B., Van Den Brule, A. J. C., Svare, E. I., Paull, G., Walbomers, J. M. M., ... Meijer, C. L. M. (2001). High-risk human papillomavirus is sexually transmitted: Evidence from a follow-up study of virgins starting sexual activity (Intercourse). Cancer Epidemiology Biomarkers and Prevention, 10(2), 101-106.

High-risk human papillomavirus is sexually transmitted : Evidence from a follow-up study of virgins starting sexual activity (Intercourse). / Kjaer, Susanne Krüger; Chackerian, Bryce; Van Den Brule, Adriaan J.C.; Svare, Edith I.; Paull, Gerson; Walbomers, Jan M.M.; Schiller, John T.; Bock, Johannes E.; Sherman, Mark E.; Lowy, Douglas R.; Meijer, Chris L.M.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 10, No. 2, 2001, p. 101-106.

Research output: Contribution to journalArticle

Kjaer, SK, Chackerian, B, Van Den Brule, AJC, Svare, EI, Paull, G, Walbomers, JMM, Schiller, JT, Bock, JE, Sherman, ME, Lowy, DR & Meijer, CLM 2001, 'High-risk human papillomavirus is sexually transmitted: Evidence from a follow-up study of virgins starting sexual activity (Intercourse)', Cancer Epidemiology Biomarkers and Prevention, vol. 10, no. 2, pp. 101-106.
Kjaer, Susanne Krüger ; Chackerian, Bryce ; Van Den Brule, Adriaan J.C. ; Svare, Edith I. ; Paull, Gerson ; Walbomers, Jan M.M. ; Schiller, John T. ; Bock, Johannes E. ; Sherman, Mark E. ; Lowy, Douglas R. ; Meijer, Chris L.M. / High-risk human papillomavirus is sexually transmitted : Evidence from a follow-up study of virgins starting sexual activity (Intercourse). In: Cancer Epidemiology Biomarkers and Prevention. 2001 ; Vol. 10, No. 2. pp. 101-106.
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