High leukocyte count is associated with peripheral vascular dysfunction in individuals with low cardiovascular risk

Jing Li, Andreas J. Flammer, Martin K. Reriani, Yoshiki Matsuo, Rajiv Gulati, Paul Andrew Friedman, Randal J. Thomas, Nicole P. Sandhu, Lilach O Lerman, Amir Lerman

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Vascular dysfunction is a surrogate marker of early-stage atherosclerosis. Serum leukocyte count is a non-traditional risk factor of cardiovascular (CV) disease and has predictive value for CV outcome. The aim of this study was to investigate the relationship between leukocyte count and peripheral vascular dysfunction. Methods and Results: In this cross-sectional study, 357 individuals without known CV disease and with low Framingham risk (10-year hard coronary artery disease risk <10%) were identified. Vascular function was measured by assessing reactive hyperemia-induced vasodilation (reactive hyperemia index, RHI). In 105 individuals with vascular dysfunction (29.4%), the median leukocyte count was significantly higher than in those with normal RHI (6.4×109/L vs. 6.0×109/L; P=0.04). The neutrophil count was the strongest predictor of impaired vascular function among leukocyte subtypes (odds ratio [OR], 2.70; 95% confidence interval [CI]: 1.58-4.60, P<0.001). In a multivariate logistic regression model, the highest quintile of neutrophil count (OR, 2.36; 95% CI: 1.35-4.12; P=0.003), body mass index (OR, 1.05; 95% CI: 1.01-1.09; P=0.009) and systolic blood pressure (OR, 0.97; 95% CI: 0.97-0.99; P<0.001) were independently predictive for vascular dysfunction. Conclusions: The highest quintile of leukocyte count is independently associated with vascular dysfunction in individuals with low CV risk. This suggests that subclinical inflammation affects vascular function. Leukocyte count may be useful for personalized risk stratification.

Original languageEnglish (US)
Pages (from-to)780-785
Number of pages6
JournalCirculation Journal
Volume77
Issue number3
DOIs
StatePublished - 2013

Fingerprint

Leukocyte Count
Blood Vessels
Hyperemia
Odds Ratio
Confidence Intervals
Neutrophils
Cardiovascular Diseases
Logistic Models
Blood Pressure
Vasodilation
Coronary Artery Disease
Atherosclerosis
Body Mass Index
Leukocytes
Cross-Sectional Studies
Biomarkers
Inflammation
Serum

Keywords

  • Framingham risk
  • Leukocyte count
  • Vascular function

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

High leukocyte count is associated with peripheral vascular dysfunction in individuals with low cardiovascular risk. / Li, Jing; Flammer, Andreas J.; Reriani, Martin K.; Matsuo, Yoshiki; Gulati, Rajiv; Friedman, Paul Andrew; Thomas, Randal J.; Sandhu, Nicole P.; Lerman, Lilach O; Lerman, Amir.

In: Circulation Journal, Vol. 77, No. 3, 2013, p. 780-785.

Research output: Contribution to journalArticle

Li, Jing ; Flammer, Andreas J. ; Reriani, Martin K. ; Matsuo, Yoshiki ; Gulati, Rajiv ; Friedman, Paul Andrew ; Thomas, Randal J. ; Sandhu, Nicole P. ; Lerman, Lilach O ; Lerman, Amir. / High leukocyte count is associated with peripheral vascular dysfunction in individuals with low cardiovascular risk. In: Circulation Journal. 2013 ; Vol. 77, No. 3. pp. 780-785.
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abstract = "Background: Vascular dysfunction is a surrogate marker of early-stage atherosclerosis. Serum leukocyte count is a non-traditional risk factor of cardiovascular (CV) disease and has predictive value for CV outcome. The aim of this study was to investigate the relationship between leukocyte count and peripheral vascular dysfunction. Methods and Results: In this cross-sectional study, 357 individuals without known CV disease and with low Framingham risk (10-year hard coronary artery disease risk <10{\%}) were identified. Vascular function was measured by assessing reactive hyperemia-induced vasodilation (reactive hyperemia index, RHI). In 105 individuals with vascular dysfunction (29.4{\%}), the median leukocyte count was significantly higher than in those with normal RHI (6.4×109/L vs. 6.0×109/L; P=0.04). The neutrophil count was the strongest predictor of impaired vascular function among leukocyte subtypes (odds ratio [OR], 2.70; 95{\%} confidence interval [CI]: 1.58-4.60, P<0.001). In a multivariate logistic regression model, the highest quintile of neutrophil count (OR, 2.36; 95{\%} CI: 1.35-4.12; P=0.003), body mass index (OR, 1.05; 95{\%} CI: 1.01-1.09; P=0.009) and systolic blood pressure (OR, 0.97; 95{\%} CI: 0.97-0.99; P<0.001) were independently predictive for vascular dysfunction. Conclusions: The highest quintile of leukocyte count is independently associated with vascular dysfunction in individuals with low CV risk. This suggests that subclinical inflammation affects vascular function. Leukocyte count may be useful for personalized risk stratification.",
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T1 - High leukocyte count is associated with peripheral vascular dysfunction in individuals with low cardiovascular risk

AU - Li, Jing

AU - Flammer, Andreas J.

AU - Reriani, Martin K.

AU - Matsuo, Yoshiki

AU - Gulati, Rajiv

AU - Friedman, Paul Andrew

AU - Thomas, Randal J.

AU - Sandhu, Nicole P.

AU - Lerman, Lilach O

AU - Lerman, Amir

PY - 2013

Y1 - 2013

N2 - Background: Vascular dysfunction is a surrogate marker of early-stage atherosclerosis. Serum leukocyte count is a non-traditional risk factor of cardiovascular (CV) disease and has predictive value for CV outcome. The aim of this study was to investigate the relationship between leukocyte count and peripheral vascular dysfunction. Methods and Results: In this cross-sectional study, 357 individuals without known CV disease and with low Framingham risk (10-year hard coronary artery disease risk <10%) were identified. Vascular function was measured by assessing reactive hyperemia-induced vasodilation (reactive hyperemia index, RHI). In 105 individuals with vascular dysfunction (29.4%), the median leukocyte count was significantly higher than in those with normal RHI (6.4×109/L vs. 6.0×109/L; P=0.04). The neutrophil count was the strongest predictor of impaired vascular function among leukocyte subtypes (odds ratio [OR], 2.70; 95% confidence interval [CI]: 1.58-4.60, P<0.001). In a multivariate logistic regression model, the highest quintile of neutrophil count (OR, 2.36; 95% CI: 1.35-4.12; P=0.003), body mass index (OR, 1.05; 95% CI: 1.01-1.09; P=0.009) and systolic blood pressure (OR, 0.97; 95% CI: 0.97-0.99; P<0.001) were independently predictive for vascular dysfunction. Conclusions: The highest quintile of leukocyte count is independently associated with vascular dysfunction in individuals with low CV risk. This suggests that subclinical inflammation affects vascular function. Leukocyte count may be useful for personalized risk stratification.

AB - Background: Vascular dysfunction is a surrogate marker of early-stage atherosclerosis. Serum leukocyte count is a non-traditional risk factor of cardiovascular (CV) disease and has predictive value for CV outcome. The aim of this study was to investigate the relationship between leukocyte count and peripheral vascular dysfunction. Methods and Results: In this cross-sectional study, 357 individuals without known CV disease and with low Framingham risk (10-year hard coronary artery disease risk <10%) were identified. Vascular function was measured by assessing reactive hyperemia-induced vasodilation (reactive hyperemia index, RHI). In 105 individuals with vascular dysfunction (29.4%), the median leukocyte count was significantly higher than in those with normal RHI (6.4×109/L vs. 6.0×109/L; P=0.04). The neutrophil count was the strongest predictor of impaired vascular function among leukocyte subtypes (odds ratio [OR], 2.70; 95% confidence interval [CI]: 1.58-4.60, P<0.001). In a multivariate logistic regression model, the highest quintile of neutrophil count (OR, 2.36; 95% CI: 1.35-4.12; P=0.003), body mass index (OR, 1.05; 95% CI: 1.01-1.09; P=0.009) and systolic blood pressure (OR, 0.97; 95% CI: 0.97-0.99; P<0.001) were independently predictive for vascular dysfunction. Conclusions: The highest quintile of leukocyte count is independently associated with vascular dysfunction in individuals with low CV risk. This suggests that subclinical inflammation affects vascular function. Leukocyte count may be useful for personalized risk stratification.

KW - Framingham risk

KW - Leukocyte count

KW - Vascular function

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DO - 10.1253/circj.CJ-12-1131

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