High Incidence of Cytomegalovirus Disease in D+/R- Heart Transplant Recipients Shortly After Completion of 3 Months of Valganciclovir Prophylaxis

Sachin Gupta, Joshua D. Mitchell, David W. Markham, Pradeep P.A. Mammen, Parag C. Patel, Patricia Kaiser, W. Steves Ring, J. Michael DiMaio, Mark H. Drazner

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26 Scopus citations

Abstract

Background: Cytomegalovirus (CMV) infection remains a serious problem after heart transplantation. Recipients with D+/R- CMV serostatus often receive prophylaxis with valganciclovir, but the optimal duration of such therapy after heart transplant is unknown. Methods: We retrospectively reviewed the clinical course of all adult cardiac transplant recipients with D+/R- CMV serostatus at the UT Southwestern Medical Center between January 2003 and December 2006. Standard immunosuppression included basiliximab induction therapy and the CMV prophylaxis included CMV hyperimmune globulin, 2 weeks of intravenous ganciclovir and 3 months of oral valganciclovir. Results: Seven patients met the study criteria. Six of the 7 patients (86%) developed CMV disease. Five of these 6 patients presented with CMV disease within 3 months of the cessation of valganciclovir prophylaxis. Conclusions: There was a high incidence of CMV disease in D+/R- heart transplant recipients despite CMV hyperimmune globulin, 2 weeks of intravenous ganciclovir and 3 months of valganciclovir prophylaxis. CMV infection occurred consistently within 2 to 3 months of cessation of valganciclovir. Alternative strategies for CMV prophylaxis, including an extension of valganciclovir prophylaxis to 6 months after heart transplantation, needs to be investigated.

Original languageEnglish (US)
Pages (from-to)536-539
Number of pages4
JournalJournal of Heart and Lung Transplantation
Volume27
Issue number5
DOIs
StatePublished - May 1 2008

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ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine
  • Transplantation

Cite this

Gupta, S., Mitchell, J. D., Markham, D. W., Mammen, P. P. A., Patel, P. C., Kaiser, P., Ring, W. S., DiMaio, J. M., & Drazner, M. H. (2008). High Incidence of Cytomegalovirus Disease in D+/R- Heart Transplant Recipients Shortly After Completion of 3 Months of Valganciclovir Prophylaxis. Journal of Heart and Lung Transplantation, 27(5), 536-539. https://doi.org/10.1016/j.healun.2008.02.002