High-frequency mode conversion technique for stiff lesion detection with Magnetic Resonance Elastography (MRE)

Yogesh K. Mariappan, Kevin J. Glaser, Armando Manduca, Anthony J. Romano, Sudhakar K Venkatesh, Meng Yin, Richard Lorne Ehman

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

A novel imaging technique is described in which the mode conversion of longitudinal waves is used for the qualitative detection of stiff lesions within soft tissue using magnetic resonance elastography (MRE) methods. Due to the viscoelastic nature of tissue, high-frequency shear waves attenuate rapidly in soft tissues but much less in stiff tissues. By introducing minimally- attenuating longitudinal waves at a significantly high frequency into tissue, shear waves produced at interfaces by mode conversion will be detectable in stiff regions, but will be significantly attenuated and thus not detectable in the surrounding soft tissue. This contrast can be used to detect the presence of stiff tissue. The proposed technique is shown to readily depict hard regions (mimicking tumors) present in tissue-simulating phantoms and ex vivo breast tissue. In vivo feasibility is demonstrated on a patient with liver metastases in whom the tumors are readily distinguished. Preliminary evidence also suggests that quantitative stiffness measurements of stiff regions obtained with this technique are more accurate than those from conventional MRE because of the short shear wavelengths. This rapid, qualitative technique may lend itself to applications in which the localization of stiff, suspicious neoplasms is coupled with more sensitive techniques for thorough characterization.

Original languageEnglish (US)
Pages (from-to)1457-1465
Number of pages9
JournalMagnetic Resonance in Medicine
Volume62
Issue number6
DOIs
StatePublished - Dec 2009

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Elasticity Imaging Techniques
Radio Waves
Neoplasms
Breast
Neoplasm Metastasis

Keywords

  • High-frequency MRE
  • Mode conversion
  • MR elastography
  • Stiff lesion detection
  • Stiffness

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

High-frequency mode conversion technique for stiff lesion detection with Magnetic Resonance Elastography (MRE). / Mariappan, Yogesh K.; Glaser, Kevin J.; Manduca, Armando; Romano, Anthony J.; Venkatesh, Sudhakar K; Yin, Meng; Ehman, Richard Lorne.

In: Magnetic Resonance in Medicine, Vol. 62, No. 6, 12.2009, p. 1457-1465.

Research output: Contribution to journalArticle

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