High-dose chemotherapy with autologous hematopoietic stem cell transplantation in patients with multiple myeloma

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Multiple myeloma, for all practical purposes, remains an incurable malignancy; however, 5-year survival has improved substantially during the past 30 years. A major contribution to improved outcome is the use of high-dose chemotherapy and stem cell transplantation. This multifaceted approach to therapy requires an understanding of appropriate induction therapy, techniques for stem cell mobilization, appropriate conditioning and supportive care. Also of importance are prognosis, features that predict outcome, the suitability of transplant candidates, and post-transplantation maintenance therapy.

Original languageEnglish (US)
Pages (from-to)343-360
Number of pages18
JournalExpert Review of Anticancer Therapy
Volume6
Issue number3
DOIs
StatePublished - Mar 2006

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Hematopoietic Stem Cell Transplantation
Multiple Myeloma
Drug Therapy
Hematopoietic Stem Cell Mobilization
Stem Cell Transplantation
Therapeutics
Transplantation
Transplants
Survival
Neoplasms

Keywords

  • Age
  • Multiple myeloma
  • Renal failure
  • Stem cell transplantation
  • Survival

ASJC Scopus subject areas

  • Cancer Research
  • Pharmacology

Cite this

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AU - Lacy, Martha

AU - Dispenzieri, Angela

AU - Hayman, Suzanne R.

AU - Kumar, Shaji K

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AB - Multiple myeloma, for all practical purposes, remains an incurable malignancy; however, 5-year survival has improved substantially during the past 30 years. A major contribution to improved outcome is the use of high-dose chemotherapy and stem cell transplantation. This multifaceted approach to therapy requires an understanding of appropriate induction therapy, techniques for stem cell mobilization, appropriate conditioning and supportive care. Also of importance are prognosis, features that predict outcome, the suitability of transplant candidates, and post-transplantation maintenance therapy.

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KW - Renal failure

KW - Stem cell transplantation

KW - Survival

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