Heterophilic Serum Antibodies: A Cause for Falsely Elevated Serum Thyrotropin Levels

MICHAEL D. BRENNAN; GEORGE G. KLEE; CAROL M. PREISSNER; IAN D. HAY

doi:10.1016/S0025-6196(12)65044-7

Heterophilic Serum Antibodies: A Cause for Falsely Elevated Serum Thyrotropin Levels

MICHAEL D. BRENNAN, GEORGE G. KLEE, CAROL M. PREISSNER, IAN D. HAY

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Abstract

We report two cases of euthyroid patients with inappropriately elevated serum levels of thyrotropin (TSH) in whom investigation led to the detection of heterophilic antibodies. In addition, we compare the performance of two TSH immunometric assay systems in this setting. Even when monoclonal assay systems are used, TSH results must be critically interpreted when they are at variance with clinical and other biochemical findings.

Original language	English (US)
Pages (from-to)	894-898
Number of pages	5
Journal	Mayo Clinic proceedings
Volume	62
Issue number	10
DOIs	https://doi.org/10.1016/S0025-6196(12)65044-7
State	Published - 1987

ASJC Scopus subject areas

General Medicine

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title = "Heterophilic Serum Antibodies: A Cause for Falsely Elevated Serum Thyrotropin Levels",

abstract = "We report two cases of euthyroid patients with inappropriately elevated serum levels of thyrotropin (TSH) in whom investigation led to the detection of heterophilic antibodies. In addition, we compare the performance of two TSH immunometric assay systems in this setting. Even when monoclonal assay systems are used, TSH results must be critically interpreted when they are at variance with clinical and other biochemical findings.",

author = "BRENNAN, {MICHAEL D.} and KLEE, {GEORGE G.} and PREISSNER, {CAROL M.} and HAY, {IAN D.}",

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AU - BRENNAN, MICHAEL D.

AU - KLEE, GEORGE G.

AU - PREISSNER, CAROL M.

AU - HAY, IAN D.

PY - 1987

Y1 - 1987

N2 - We report two cases of euthyroid patients with inappropriately elevated serum levels of thyrotropin (TSH) in whom investigation led to the detection of heterophilic antibodies. In addition, we compare the performance of two TSH immunometric assay systems in this setting. Even when monoclonal assay systems are used, TSH results must be critically interpreted when they are at variance with clinical and other biochemical findings.

AB - We report two cases of euthyroid patients with inappropriately elevated serum levels of thyrotropin (TSH) in whom investigation led to the detection of heterophilic antibodies. In addition, we compare the performance of two TSH immunometric assay systems in this setting. Even when monoclonal assay systems are used, TSH results must be critically interpreted when they are at variance with clinical and other biochemical findings.

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Heterophilic Serum Antibodies: A Cause for Falsely Elevated Serum Thyrotropin Levels

Abstract

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