TY - JOUR
T1 - Herpes simplex virus infections and Alzheimer's disease
T2 - Implications for drug treatment and immunotherapy
AU - Leissring, Malcolm A.
AU - Sugarman, Michael C.
AU - LaFerla, Frank M.
N1 - Funding Information:
This study was supported in part by a grant from the Lucille P. Markey Charitable Trust and grants from NIA (#AG14864-01).
PY - 1998
Y1 - 1998
N2 - Interest in the possible role of herpes simplex virus type 1 (HSV1) as a cofactor in the pathogenesis of Alzheimer's disease (AD) has re-emerged following the detection of viral DNA sequences in the central nervous system (CNS). Evidence from 2 independent laboratories indicates that HSV1 may interact with a host-specific factor, the apolipoprotein Eε4 allele, to further augment the risk for AD. In this review, we consider the arguments implicating HSV1 in the pathogenesis of AD. Although further studies are required to confirm a role for HSV1 in AD and to elucidate its underlying molecular basis, implicating a virus in the pathogenesis of this insidious disease clearly offers novel potential treatments.
AB - Interest in the possible role of herpes simplex virus type 1 (HSV1) as a cofactor in the pathogenesis of Alzheimer's disease (AD) has re-emerged following the detection of viral DNA sequences in the central nervous system (CNS). Evidence from 2 independent laboratories indicates that HSV1 may interact with a host-specific factor, the apolipoprotein Eε4 allele, to further augment the risk for AD. In this review, we consider the arguments implicating HSV1 in the pathogenesis of AD. Although further studies are required to confirm a role for HSV1 in AD and to elucidate its underlying molecular basis, implicating a virus in the pathogenesis of this insidious disease clearly offers novel potential treatments.
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U2 - 10.2165/00002512-199813030-00002
DO - 10.2165/00002512-199813030-00002
M3 - Article
C2 - 9789723
AN - SCOPUS:0031659767
SN - 1170-229X
VL - 13
SP - 193
EP - 198
JO - Drugs and Aging
JF - Drugs and Aging
IS - 3
ER -