Hereditary sensory neuropathy, type II. Clinical, electrophysiologic, histologic, and biochemical studies of a Quebec kinship

M. Ohta, R. D. llefson, E. H. Lambert, Peter J Dyck

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Abstract

Members of a kinship with recessive hereditary sensory neuropathy (HSN type II) and a person from another kinship with the dominant hereditary variety (HSN type I) were investigated with quantitative studies of cutaneous touch pressure, temperature discrimination, and pricking pain sensations, in vitro study of compound action potential and histologic studies of sural nerve biopsy specimens, and analysis of lipids of open liver biopsy specimens. In contrast to the type I disorder, the type II disorder is already present at birth or shortly thereafter, sensation is abnormal more diffusely over the body, touch pressure sensation is affected more than pain and temperature sensations, and myelinated fibers are more affected than unmyelinated fibers. No lipid abnormality was found.

Original languageEnglish (US)
Pages (from-to)23-37
Number of pages15
JournalArchives of Neurology
Volume29
Issue number1
StatePublished - 1973

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Hereditary Sensory and Autonomic Neuropathies
Quebec
Touch
Lipids
Biopsy
Pressure
Pain
Sural Nerve
Temperature
Action Potentials
Parturition
Skin
Kinship
Liver

ASJC Scopus subject areas

  • Neuroscience(all)

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Hereditary sensory neuropathy, type II. Clinical, electrophysiologic, histologic, and biochemical studies of a Quebec kinship. / Ohta, M.; llefson, R. D.; Lambert, E. H.; Dyck, Peter J.

In: Archives of Neurology, Vol. 29, No. 1, 1973, p. 23-37.

Research output: Contribution to journalArticle

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