Hereditary nonpolyposis colorectal cancer

Erik C. Thorland; Stephen N. Thibodeau

doi:10.1007/978-0-387-33227-7_19

Hereditary nonpolyposis colorectal cancer

Erik C. Thorland, Stephen N. Thibodeau

Laboratory Medicine and Pathology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant colon cancer syndrome. The first description of a cancer-prone family with HNPCC dates back to the late 1800s.1 However, it was not until the work of Lynch in the 1970s that a more complete clinical picture of this disorder began to emerge.2,3 The diagnosis of HNPCC has, until recently, been based primarily on family history. As a result, reliably differentiating patients with HNPCC from those with sporadic cancer has been difficult. However, the constellation of several clinical characteristics, in addition to family history, may raise suspicion of HNPCC.

Original language	English (US)
Title of host publication	Molecular Pathology in Clinical Practice
Publisher	Springer New York
Pages	223-232
Number of pages	10
ISBN (Print)	038733226X, 9780387332260
DOIs	https://doi.org/10.1007/978-0-387-33227-7_19
State	Published - 2007

ASJC Scopus subject areas

General Medicine

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10.1007/978-0-387-33227-7_19

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AB - Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant colon cancer syndrome. The first description of a cancer-prone family with HNPCC dates back to the late 1800s.1 However, it was not until the work of Lynch in the 1970s that a more complete clinical picture of this disorder began to emerge.2,3 The diagnosis of HNPCC has, until recently, been based primarily on family history. As a result, reliably differentiating patients with HNPCC from those with sporadic cancer has been difficult. However, the constellation of several clinical characteristics, in addition to family history, may raise suspicion of HNPCC.

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ER -

Hereditary nonpolyposis colorectal cancer

Abstract

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