Hepatocyte transplantation: New horizons and challenges

Harmeet Malhi, Sanjeev Gupta

Research output: Contribution to journalArticle

62 Scopus citations

Abstract

Hepatocyte transplantation represents an alternative strategy for treating liver disease. Liver repopulation following acute liver failure could, potentially, eliminate the requirement for orthotopic liver transplantation. Similarly, the ability to repopulate the liver with disease-resistant hepatocytes offers new opportunities for correcting genetic disorders and treating patients with chronic liver disease. Recent advances concerning the fate of transplanted cells in the recipient liver, the efficacy of cell therapy in outstanding animal models of human disease, and the isolation of progenitor liver cells capable of differentiating into mature hepatocytes have renewed optimism in regard to treating people with hepatocyte transplantation. Recruitment of an increasing number of investigators to the field and the success of recent pilot studies indicate that hepatocyte transplantation will become routine clinical practice in the near future.

Original languageEnglish (US)
Pages (from-to)40-50
Number of pages11
JournalJournal of Hepato-Biliary-Pancreatic Surgery
Volume8
Issue number1
DOIs
StatePublished - Dec 1 2001

Keywords

  • Hepatocyte
  • Liver
  • Transplantation
  • Treatment

ASJC Scopus subject areas

  • Surgery
  • Hepatology

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