Hepatocyte transplantation: New horizons and challenges

Harmeet M Malhi, Sanjeev Gupta

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Hepatocyte transplantation represents an alternative strategy for treating liver disease. Liver repopulation following acute liver failure could, potentially, eliminate the requirement for orthotopic liver transplantation. Similarly, the ability to repopulate the liver with disease-resistant hepatocytes offers new opportunities for correcting genetic disorders and treating patients with chronic liver disease. Recent advances concerning the fate of transplanted cells in the recipient liver, the efficacy of cell therapy in outstanding animal models of human disease, and the isolation of progenitor liver cells capable of differentiating into mature hepatocytes have renewed optimism in regard to treating people with hepatocyte transplantation. Recruitment of an increasing number of investigators to the field and the success of recent pilot studies indicate that hepatocyte transplantation will become routine clinical practice in the near future.

Original languageEnglish (US)
Pages (from-to)40-50
Number of pages11
JournalJournal of Hepato-Biliary-Pancreatic Surgery
Volume8
Issue number1
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Hepatocytes
Transplantation
Liver Diseases
Liver
Animal Disease Models
Inborn Genetic Diseases
Aptitude
Acute Liver Failure
Cell- and Tissue-Based Therapy
Liver Transplantation
Chronic Disease
Stem Cells
Research Personnel

Keywords

  • Hepatocyte
  • Liver
  • Transplantation
  • Treatment

ASJC Scopus subject areas

  • Surgery

Cite this

Hepatocyte transplantation : New horizons and challenges. / Malhi, Harmeet M; Gupta, Sanjeev.

In: Journal of Hepato-Biliary-Pancreatic Surgery, Vol. 8, No. 1, 2001, p. 40-50.

Research output: Contribution to journalArticle

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